Hypercalcitonemia in Bronchogenic Cancer: Title and subTitle BreakEvidence for Thyroid Origin of the Hormone FREE

Omega L. Silva, MD; Kenneth L. Becker, MD, PhD; Aron Primack, MD; John L. Doppman, MD; Richard H. Snider, PhD

[+] Author Affiliations

Reprint requests to Metabolic Research (151-J), Veterans Administration Hospital, 50 Irving St, NW, Washington, DC 20422 (Dr Silva).

JAMA. 1975;234(2):183-185. doi:10.1001/jama.1975.03260150053022

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ABSTRACT

ABSTRACT | REFERENCES

Retrograde venous catheterization in a hypercalcitonemic patient with adenocarcinoma of the lung demonstrated that the thyroid gland was secreting a very large amount of hormone (14-fold higher than the peripheral level), while the venous drainage from the tumor deposits was similar in concentration to that of the periphery. Conceivably, the calcitonin is being elaborated in response to metastatic and humoral bone resorption or both. Radiotherapy resulted in a decrease in the calcitonin level. Further studies are needed to determine the diagnostic or prognostic implications of serum calcitonin in bronchogenic cancer.

(JAMA 234:183-185, 1975)

REFERENCES

ABSTRACT | REFERENCES

Silva OL, Snider RH, Becker KL: Radioimmunoassay of human calcitonin in human plasma . Clin Chem 20:337-339, 1974;.

Silva OL, Becker KL, Snider RH: Secondary hypercalcitonemia . Clin Res 22:480A, 1974;.

Silva OL, Becker KL, Primack A, et al: Ectopic production of calcitonin . Lancet 2:317, 1973;.

Silva OL, Becker KL, Primack A, et al: Ectopic production of calcitonin in oat cell carcinoma . N Engl J Med 290:1122-1124, 1974;.

Silva OL, Becker KL, Primack A, et al: Hypercalcitonemia in man . Pharmacologist 15:252, 1973;.

Coombes RC, Greenberg PB, Hillyard C, et al: Plasma-immunoreactive-calcitonin in patients with non-thyroid tumors . Lancet 1:1080-1083, 1974;.

Doppman JL, Melson GL, Evens RG, et al: Selective superior and inferior thyroid vein catheterization: Venographic anatomy and potential applications . Invest Radiol 4:97-99, 1969;.

Silva OL, Becker KL, Doppman J, et al: Calcitonin levels in thyroid-vein blood in man . Am J Med Sci 269:37-41, 1975;.

Tashjian AH Jr, Howland BG, Melvin KW, et al: Immunoassay of human calcitonin: Clinical measurement, relation to serum calcium and studies in patients with medullary carcinoma . N Engl J Med 283:890, 1970;.

Milhaud G, Calmette C, Taboulet J, et al: Hypersecretion of calcitonin in neoplastic conditions . Lancet 1:462, 1974;.

Voelkel EF, Tashjian AH Jr, Davidoff FF, et al: Concentrations of calcitonin and catecholamines in pheochromocytomas, a mucosal neuroma and medullary thyroid carcinoma . J Clin Endocrinol Metab 37:297, 1973;.

Kaplan EL, Sizemore G, Hill BJ, et al: Calcitonin in nonthyroid tumors in man . Clin Res 4:724, 1972;.

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