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Hepatitis Types B and Non-B: Title and subTitle BreakEpidemiologic Background FREE

James W. Mosley, MD
[+] Author Affiliations

Reprint requests to Hepatic Epidemiology Laboratory, John Wesley County Hospital, 2826 S Hope St, Los Angeles, CA 90007 (Dr. Mosley).


JAMA. 1975;233(9):967-969. doi:10.1001/jama.1975.03260090033016
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Two episodes of acute viral hepatitis occurred in each of 34 patients. One episode in each patient was serologically diagnosable as type B hepatitis on the basis of tests for hepatitis B surface antigen or antibody. The other episode was classified as "non-B" on the basis of seronegativity, reinforced by seropositivity in an alternate bout. An epidemiologic background appropriate to "serum" hepatitis, either transfusion (one bout) or illicit self-injection (46 bouts), was associated just as frequently with serologically non-B episodes as with identified type B disease. The diagnosis of type B hepatitis, therefore, should be made only on the basis of serologic tests specific for hepatitis B virus infection. Other cases of sporadic disease in adults must be labeled "viral hepatitis, type unspecifiable."

(JAMA 233:967-969, 1975)

REFERENCES

Prince AM, Hargrove RL, Szmuness W, et al:  Immunologic distinction between infectious and serum hepatitis . N Engl J Med 282:987-991, 1970;.
Cossart YE, Vahrman J:  Studies of Australia-SH antigen in sporadic viral hepatitis in London . Br Med J 1:403-405, 1970;.
Prince AM, Brotman B, Grady GF, et al:  Long-incubation post-transfusion hepatitis without serological evidence of exposure to hepatitis-B virus . Lancet 2:241-246, 1974;.
Sutnick AI, Cerda JJ, Toskes PP, et al:  Australia antigen and viral hepatitis in drug abusers . Arch Intern Med 127:939-941, 1971;.
Kaplan PM, Greenman RL, Gerin JL, et al:  DNA polymerase associated with human hepatitis B antigen . J Virol 12:995-1005, 1973;.
Hoofnagle JH, Gerety RJ, Barker LF:  Antibody to hepatitis-B-virus core in man . Lancet 2:869-873, 1973;.
Havens WP Jr:  Infectious hepatitis . Medicine 27:279-326, 1948;.
Karvountzis GG, Mosley JW, Redeker AG:  Serologic characterization of patients with two episodes of acute viral hepatitis . Am J Med 58:815-822, 1975;.
Ling CM, Overby LR:  Prevalence of hepatitis B virus antigen as revealed by direct radio immune assay with 125 I-antibody . J Immunol 109:834-841, 1972;.
Vyas GN, Shulman NR:  Hemagglutination assay for antigen and antibody associated with viral hepatitis . Science 170:332-333, 1970;.
Mosley JW:  Epidemiologic implications of changing trends in type A and type B hepatitis , in Vyas GN, Perkins HA, Schmid R (eds): Hepatitis and Blood Transfusion . New York, Grune & Stratton, Inc, 1972;, pp 23-36.
Dietzman DE, Matthew EB, Madden DL, et al:  The occurrence of epidemic infectious hepatitis in chronic carriers of Australia antigen . J Pediatr 80:577-582, 1972;.

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Prince AM, Hargrove RL, Szmuness W, et al:  Immunologic distinction between infectious and serum hepatitis . N Engl J Med 282:987-991, 1970;.
Cossart YE, Vahrman J:  Studies of Australia-SH antigen in sporadic viral hepatitis in London . Br Med J 1:403-405, 1970;.
Prince AM, Brotman B, Grady GF, et al:  Long-incubation post-transfusion hepatitis without serological evidence of exposure to hepatitis-B virus . Lancet 2:241-246, 1974;.
Sutnick AI, Cerda JJ, Toskes PP, et al:  Australia antigen and viral hepatitis in drug abusers . Arch Intern Med 127:939-941, 1971;.
Kaplan PM, Greenman RL, Gerin JL, et al:  DNA polymerase associated with human hepatitis B antigen . J Virol 12:995-1005, 1973;.
Hoofnagle JH, Gerety RJ, Barker LF:  Antibody to hepatitis-B-virus core in man . Lancet 2:869-873, 1973;.
Havens WP Jr:  Infectious hepatitis . Medicine 27:279-326, 1948;.
Karvountzis GG, Mosley JW, Redeker AG:  Serologic characterization of patients with two episodes of acute viral hepatitis . Am J Med 58:815-822, 1975;.
Ling CM, Overby LR:  Prevalence of hepatitis B virus antigen as revealed by direct radio immune assay with 125 I-antibody . J Immunol 109:834-841, 1972;.
Vyas GN, Shulman NR:  Hemagglutination assay for antigen and antibody associated with viral hepatitis . Science 170:332-333, 1970;.
Mosley JW:  Epidemiologic implications of changing trends in type A and type B hepatitis , in Vyas GN, Perkins HA, Schmid R (eds): Hepatitis and Blood Transfusion . New York, Grune & Stratton, Inc, 1972;, pp 23-36.
Dietzman DE, Matthew EB, Madden DL, et al:  The occurrence of epidemic infectious hepatitis in chronic carriers of Australia antigen . J Pediatr 80:577-582, 1972;.
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