Practical Guidelines for the Use of Lidocaine: Title and subTitle BreakPrevention and Treatment of Cardiac Arrhythmias FREE

Donald C. Harrison, MD

[+] Author Affiliations

Reprint requests to Cardiology Division, Stanford University School of Medicine, 300 Pasteur Dr, Stanford, CA 94305 (Dr. Harrison).

JAMA. 1975;233(11):1202-1204. doi:10.1001/jama.1975.03260110060027

Text Size: A A A

Published online

Article

References

ABSTRACT

ABSTRACT | REFERENCES

ALTHOUGH lidocaine hydrochloride was synthesized as a local anesthetic drug in 1943, its antiarrhythmic property was not recognized until the late 1950s, when anesthesiologists used the drug in the operating room for treating ventricular arrhythmias that occurred during the course of open heart surgery.¹ In 1963, a detailed study² reported the comparison of lidocaine with procainamide for treating intraoperative and postoperative ventricular arrhythmias in patients undergoing cardiac surgery. This study demonstrated that lidocaine was safe, highly effective, and preferable to procainamide for such arrhythmias.

With the development of the coronary care unit during the 1960s, lidocaine was found to be an important agent in controlling life-threatening arrhythmias,³ and in 1967, its use for the treatment of less serious ventricular rhythm disturbances, which frequently herald the development of life-threatening arrhythmias, was proposed.⁴ Subsequently, it gained general acceptance in the coronary care unit for both treating and preventing

REFERENCES

ABSTRACT | REFERENCES

Kimmey JR, Steinhaus JE: Cardiovascular effects of procaine and lidocaine (Xylocaine) during general anesthesia . Acta Anaesthiol Scand 3:9-12, 1959;.

Harrison DC, Sprouse JC, Morrow AG: The antiarrhythmic properties of lidocaine and procainamide . Circulation 28:486-491, 1963;.

Lown B, Fakhro AM, Hood WB, et al: The coronary care unit: New perspectives and directions . JAMA 199:188-198, 1967;.

Gianelly RE, von der Groeben JO, Spivack AP, et al: Effects of lidocaine on ventricular arrhythmias in patients with coronary heart disease . N Engl J Med 277:1215-1219, 1967;.

Harrison DC, Alderman EL: The pharmacology and clinical use of lidocaine as an antiarrhythmic drug—1972 . Mod Treat 9:139-175, 1972;.

Jewitt DE, Kishon Y, Thomas M: Lignocaine in the management of arrhythmias after myocardial infarction . Lancet 1:266-270, 1968;.

Wyman MG, Hammersmith L: Comprehensive treatment plan for the prevention of primary ventricular fibrillation in acute myocardial infarction . Am J Cardiol 33:661-667, 1974;.

Lie KI, Wellens HJ, Van Capelle FJ, et al: Lidocaine in the prevention of primary ventricular fibrillation . N Engl J Med 291:1324-1326, 1974;.

Rowland M, Thomson PD, Gruchard A, et al: Disposition kinetics of lidocaine in normal subjects . Ann NY Acad Sci 179:383-398, 1971;.

Collinsworth KA, Kalman SM, Harrison DC: The clinical pharmacology of lidocaine as an antiarrhythmic drug . Circulation 50:1217-1230, 1974;.

Stenson RE, Constantino RT, Harrison DC: Interrelationship of hepatic blood flow, cardiac output, and blood levels of lidocaine in man . Circulation 43:205-211, 1971;.

Fehmers M, Dunning A: Intramuscularly and orally administered lidocaine in the treatment of ventricular arrhythmias in acute myocardial infarction . Am J Cardiol 29:514-519, 1972;.

Alderman EL, Kerber RD, Harrison DC: Evaluation of lidocaine resistance in man using intermittent high-dose infusion techniques . Am J Cardiol 34:342-349, 1974;.

Winkle RA, Glantz SA, Harrison DC: Pharmacologic therapy of ventricular arrhythmias . Am J Cardiol , to be published.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal