0
ARTICLE |

Diagnosis of Acute Myocardial Infarction: Title and subTitle BreakRelative Efficiency of Serum Enzyme and Isoenzyme Measurements FREE

Robert S. Galen, MD, MPH; James A. Reiffel, MD; S. Raymond Gambino, MD
[+] Author Affiliations

Reprint requests to BHA 4, 622 W 168th St, New York, NY 10032 (Dr. Gambino).


JAMA. 1975;232(2):145-147. doi:10.1001/jama.1975.03250020019017
Text Size: A A A
Published online

Total serum enzyme activity for creatine phosphokinase (CPK), alphahydroxybutyric dehydrogenase (HBDH), lactic dehydrogenase (LDH), and serum glutamic oxaloacetic transaminase (SGOT), as well as the isoenzymes of CPK and LDH, were measured on admission and for ten subsequent days in 100 patients admitted consecutively to a coronary care unit. On discharge, patients were classified by a cardiologist as either having or not having suffered an acute myocardial infarction (MI) on the basis of clinical and electrocardiographic criteria—without knowledge of the enzyme studies. The combined use of CPK and LDH isoenzyme levels provided the greatest laboratory discrimination between the two clinical groups (MI vs non-MI). The routine use of HBDH and SGOT levels can be abandoned in the setting of a coronary care unit if CPK and LDH isoenzyme assays are available.

(JAMA 232:145-147, 1975)

REFERENCES

Ferrer MIF: Electrocardiographic Notebook , ed 3. New York, Paul B. Hoeber, Inc, 1968;.
Konttinen A, Somer H:  Specificity of serum creatine kinase isoenzymes in diagnosis of acute myocardial infarction . Br Med J 1:386-389, 1973;.
Klein MS, Shell WE, Sobel BE:  Serum creatine phosphokinase (CPK) isoenzymes after intramuscular injections, surgery, and myocardial infarction . Cardiovasc Res 7:412-418, 1973;.
Wagner GS, Roe CR, Limbird LE, et al:  The importance of identification of the myocardialspecific isoenzyme of creatine phosphokinase (MB form) in the diagnosis of acute myocardial infarction . Circulation 47:263-268, 1973;.
Elevitch F: Fluorometric Techniques in Clinical Chemistry . Boston, Little Brown & Co, 1973;.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Ferrer MIF: Electrocardiographic Notebook , ed 3. New York, Paul B. Hoeber, Inc, 1968;.
Konttinen A, Somer H:  Specificity of serum creatine kinase isoenzymes in diagnosis of acute myocardial infarction . Br Med J 1:386-389, 1973;.
Klein MS, Shell WE, Sobel BE:  Serum creatine phosphokinase (CPK) isoenzymes after intramuscular injections, surgery, and myocardial infarction . Cardiovasc Res 7:412-418, 1973;.
Wagner GS, Roe CR, Limbird LE, et al:  The importance of identification of the myocardialspecific isoenzyme of creatine phosphokinase (MB form) in the diagnosis of acute myocardial infarction . Circulation 47:263-268, 1973;.
Elevitch F: Fluorometric Techniques in Clinical Chemistry . Boston, Little Brown & Co, 1973;.
CME Course for:


You need to register in order to view this quiz.


To understand the clinical management of acute heart failure syndromes.
Accreditation Information The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
To view and print your certificate and access a summary of your CME courses go to My CME.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.