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July 1, 1974, Vol 229, No. 1 >
ARTICLE | July 1, 1974

Pancreatitis and Lipase: Title and subTitle BreakA Reevaluation With a Five-Minute Turbidimetric Lipase Determination FREE

Lester J. Lifton, MD; Kenneth A. Slickers, PhD; Desider A. Pragay, PhD; Leonard A. Katz, MD
[+] Author Affiliations

Reprint requests to Gastrointestinal Unit, E. J. Meyer Memorial Hospital, 462 Grider St, Buffalo, NY 14215 (Dr. Katz).


JAMA. 1974;229(1):47-50. doi:10.1001/jama.1974.03230390023017
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References

Lipase activity was simultaneously determined with amylase activity in the sera of 30 hospitalized patients with acute pancreatitis. On admission to the study, 70% of patients with acute pancreatitis had increased serum amylase, 63% had increased lipase, and 83% had increased lipase, increased amylase, or both.

All patients had either lipase or amylase increase at some time during the course of their disease. Lipase level elevation paralleled the amylase in the majority of cases. There were several instances of earlier elevation of the lipase level.

The traditional thesis that lipase level elevation occurs later and lasts longer than that of amylase was not confirmed. Measurement of serum amylase and lipase levels together will improve diagnostic accuracy in acute pancreatitis.

(JAMA 229:47-50, 1974)

REFERENCES

1 +
Martinek RG:  Longevity of serum lipase values in pancreatitis: Medical myth or reality . Am J Technol 31:417-419, 1965;.
2 +
Desnuelle P:  Pancreatic lipase . Adv Enzymol 23:129-161, 1961;.
3 +
Cherry IS, Crandall LA:  Specificity of pancreatic lipase: Its appearance in blood after pancreatic injury . Am J Physiol 100:266-273, 1932;.
4 +
Shihabi Z, Bishop C:  Simplified turbidimetric assay for lipase activity . Clin Chem 17:1150-1153, 1971;.
5 +
Tickton HE, et al:  Diagnostic value of a new serum lipase method . Gastroenterology 48:12-17, 1965;.
6 +
Tietz NW, Borden T, Stapleton JD:  An improved method for the determination of lipase in serum . Am J Clin Pathol 31:148-154, 1959;.
7 +
Gomori G:  Assay of serum amylase with small amounts of serum . Am J Clin Pathol 27:714-716, 1957;.
8 +
Dirstine PH, Sobel C, Henry RJ:  A new, rapid method for the determination of serum lipase . Clin Chem 14:1097-1106, 1968;.
9 +
Spiro HM: Clinical Gastroenterology . New York, The Macmillan Co, 1970;, p 791.
10 +
Bockus HL: Gastroenterology , ed 2. Philadelphia, WB Saunders Co, 1966;, vol 3, p 964.
11 +
Kowlessar OD:  Disease of the pancreas , in Beeson PB, McDermott W (eds): Cecil-Loeb Textbook of Medicine , ed 12. Philadelphia, WB Saunders Co, 1967;, pp 903-917.
12 +
Comfort MW, Osterberg AE:  Serum amylase and serum lipase in the diagnosis of disease of the pancreas . Med Clin North Am 24:1137-1149, 1940;.
13 +
Bockus HL, Raffensperger EC:  Acute pancreatitis . NY State J Med 48:2252-2259, 1948;.
14 +
Brobst D, Ferguson AB, Carter JM:  Evaluation of serum amylase and lipase activity in experimentally induced pancreatitis in the dog . J Am Vet Med Assoc 157:1697-1702, 1970;.
15 +
Berk JE:  Serum amylase and lipase: Newer perspectives . JAMA 199:98-102, 1967;.
16 +
Shiwara HW:  Ein UV-test zur Messung der α-Amylase Activität in Serum and Urin . Z Klin Chem Klin Biochem 10:12-16, 1972;.
17 +
O'Neal WR, Gochman N:  An automated, saccharogenic method for determining serum amylase activity . Clin Chem 16:985-989, 1970;.
18 +
Fleisher M, Schwartz MK:  An automated, fluorometric procedure for determining serum lipase . Clin Chem 17:417-422, 1971;.
19 +
Tietz N, Fiereck EA:  A specific method for serum lipase determination . Clin Chem Acta 13:352-358, 1966;.
20 +
Vogel WC, Zieve L:  A rapid and sensitive turbidimetric method of serum lipase based upon differences between the lipases of normal and pancreatitis serum . Clin Chem 9:169-181, 1963;.
21 +
Song H, Tietz NW, Tan C:  Usefulness of serum lipase, esterase and amylase estimation in the diagnosis of pancreatitis: A comparison . Clin Chem 16:264-268, 1970;.
22 +
Guth PH:  Evaluation of phototurbidimetric technics for the determination of serum amylase, lipase, and esterase . Am J Gastroenterol 33:319-334, 1960;.
23 +
Janowitz HD, Dreiling DA:  The plasma amylase . Am J Med 27:924-935, 1959;.
24 +
Seward C:  Diagnosing pancreatitis the first day . South Med J 63:282-286, 1970;.
25 +
Batsakis JG, et al:  Clinical enzymology: III. Serum and urinary amylase and lipase in acute pancreatitis . Univ Mich Med Cent J 31:117-120, 1965;.
26 +
Patt HH, et al:  Serum lipase determination in acute pancreatitis . Arch Surg 92:718-723, 1966;.

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1 +
Martinek RG:  Longevity of serum lipase values in pancreatitis: Medical myth or reality . Am J Technol 31:417-419, 1965;.
2 +
Desnuelle P:  Pancreatic lipase . Adv Enzymol 23:129-161, 1961;.
3 +
Cherry IS, Crandall LA:  Specificity of pancreatic lipase: Its appearance in blood after pancreatic injury . Am J Physiol 100:266-273, 1932;.
4 +
Shihabi Z, Bishop C:  Simplified turbidimetric assay for lipase activity . Clin Chem 17:1150-1153, 1971;.
5 +
Tickton HE, et al:  Diagnostic value of a new serum lipase method . Gastroenterology 48:12-17, 1965;.
6 +
Tietz NW, Borden T, Stapleton JD:  An improved method for the determination of lipase in serum . Am J Clin Pathol 31:148-154, 1959;.
7 +
Gomori G:  Assay of serum amylase with small amounts of serum . Am J Clin Pathol 27:714-716, 1957;.
8 +
Dirstine PH, Sobel C, Henry RJ:  A new, rapid method for the determination of serum lipase . Clin Chem 14:1097-1106, 1968;.
9 +
Spiro HM: Clinical Gastroenterology . New York, The Macmillan Co, 1970;, p 791.
10 +
Bockus HL: Gastroenterology , ed 2. Philadelphia, WB Saunders Co, 1966;, vol 3, p 964.
11 +
Kowlessar OD:  Disease of the pancreas , in Beeson PB, McDermott W (eds): Cecil-Loeb Textbook of Medicine , ed 12. Philadelphia, WB Saunders Co, 1967;, pp 903-917.
12 +
Comfort MW, Osterberg AE:  Serum amylase and serum lipase in the diagnosis of disease of the pancreas . Med Clin North Am 24:1137-1149, 1940;.
13 +
Bockus HL, Raffensperger EC:  Acute pancreatitis . NY State J Med 48:2252-2259, 1948;.
14 +
Brobst D, Ferguson AB, Carter JM:  Evaluation of serum amylase and lipase activity in experimentally induced pancreatitis in the dog . J Am Vet Med Assoc 157:1697-1702, 1970;.
15 +
Berk JE:  Serum amylase and lipase: Newer perspectives . JAMA 199:98-102, 1967;.
16 +
Shiwara HW:  Ein UV-test zur Messung der α-Amylase Activität in Serum and Urin . Z Klin Chem Klin Biochem 10:12-16, 1972;.
17 +
O'Neal WR, Gochman N:  An automated, saccharogenic method for determining serum amylase activity . Clin Chem 16:985-989, 1970;.
18 +
Fleisher M, Schwartz MK:  An automated, fluorometric procedure for determining serum lipase . Clin Chem 17:417-422, 1971;.
19 +
Tietz N, Fiereck EA:  A specific method for serum lipase determination . Clin Chem Acta 13:352-358, 1966;.
20 +
Vogel WC, Zieve L:  A rapid and sensitive turbidimetric method of serum lipase based upon differences between the lipases of normal and pancreatitis serum . Clin Chem 9:169-181, 1963;.
21 +
Song H, Tietz NW, Tan C:  Usefulness of serum lipase, esterase and amylase estimation in the diagnosis of pancreatitis: A comparison . Clin Chem 16:264-268, 1970;.
22 +
Guth PH:  Evaluation of phototurbidimetric technics for the determination of serum amylase, lipase, and esterase . Am J Gastroenterol 33:319-334, 1960;.
23 +
Janowitz HD, Dreiling DA:  The plasma amylase . Am J Med 27:924-935, 1959;.
24 +
Seward C:  Diagnosing pancreatitis the first day . South Med J 63:282-286, 1970;.
25 +
Batsakis JG, et al:  Clinical enzymology: III. Serum and urinary amylase and lipase in acute pancreatitis . Univ Mich Med Cent J 31:117-120, 1965;.
26 +
Patt HH, et al:  Serum lipase determination in acute pancreatitis . Arch Surg 92:718-723, 1966;.

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