0
January 21, 1974, Vol 227, No. 3 >
ARTICLE | January 21, 1974

Viruses as Precipitants of Asthmatic Attacks in Children FREE

Theodore E. Minor, PhD; Elliot C. Dick, PhD; Anthony N. DeMeo, MD; John J. Ouellette, MD; Marcus Cohen, MD; Charles E. Reed, MD
[+] Author Affiliations

Reprint requests to 465 Henry Mall, Madison, WI 53706 (Dr. Dick).


JAMA. 1974;227(3):292-298. doi:10.1001/jama.1974.03230160020004
Text Size: A A A
Published online
Article
References

Evidence for the exacerbation of asthma by specific infectious agents was sought in an October 1971 through May 1972 outpatient study of 16 children with histories of wheezing associated with apparent symptomatic respiratory infections (SRI). Clinical data were collected daily, and pharyngeal and nasal specimens were obtained routinely for microbiological analyses. Subjects experienced 61 episodes of asthma, and 42 of these were coincident with an apparent SRI. Asthmatic attacks occurred with 38 of 49 severe SRI, but only 4 of 22 mild SRI were similarly associated. Asthma was precipitated during 21 of 23 severe SRI of viral origin, but in only one of six severe SRI of bacterial origin. Fourteen of 15 rhinovirus infections that resulted in severe SRI and all episodes of A2/Hong Kong influenza were associated with attacks of asthma. No asthma was noted during episodes of asymptomatic virus shedding.

REFERENCES

1 +
Ford RM:  Aetiology of asthma: A review of 11,551 cases (1958 to 1968) . Med J Aust 14:628-631, 1969;.
2 +
Williams H, McNicol KN:  Prevalence, natural history, and relationship of wheezy bronchitis and asthma in children: An epidemiological study . Br Med J 9:321-325, 1969;.
3 +
Sanders S, Normal AP:  The bacterial flora of the upper respiratory tract in children with severe asthma . J Allergy 41:319-325, 1968;.
4 +
Berman S, et al:  Transcricothyroid cultures in "infectious" asthma . J Allergy Clin Immunol 51:122, 1973;.
5 +
Berkovich S, Millain SJ, Snyder RD:  The association of viral and mycoplasma infections with the recurrence of wheezing in the asthmatic child . Ann Allergy 28:43-49, 1970;.
6 +
McIntosh K, et al:  The association of viral and bacterial respiratory infections with exacerbations of wheezing in young asthmatic children . J Pediatr 82:578-590, 1973;.
7 +
Dick EC, et al:  Viruses as precipitants of asthmatic attacks in children . Clin Res 20:799, 1972;.
8 +
Evans AS, Dick EC:  Acute pharyngitis and tonsillitis in University of Wisconsin students . JAMA 190:699-708, 1964;.
9 +
Cherry JD, Diddams JA, Dick EC:  Rhinovirus infections in hospitalized children: Provocative bacterial interrelationships . Arch Environ Health 14:390-396, 1967;.
10 +
Dick EC, Blumer CR, Evans AS:  Epidemiology of infections with rhinovirus types 43 and 55 in a group of University of Wisconsin student families . Am J Epidemiol 86:386-400, 1967;.
11 +
D'Alessio DJ, Cox PM, Dick EC:  Failure of inactivated influenza vaccine to protect an aged population . JAMA 210:485-489, 1969;.
12 +
Parker CD, Bilbo RE, Reed CE:  Methacholine aerosol as a test for bronchial asthma . Arch Intern Med 115:452-458, 1965;.
13 +
Ouellette JJ, Reed CE:  Increased response of asthmatic subjects to methacholine after influenza vaccine . J Allergy 36:558-563, 1965;.
14 +
Reed CE, Cohen M, Enta T:  Reduced effect of epinephrine on circulating eosinophils in asthma and after beta adrenergic blockade or Bordetella pertussis vaccine: With a note on eosinopenia after methacholine . J Allergy 46:90-102, 1970;.
15 +
Allen V, Sueltmann S, Lawson C:  Laboratory diagnosis of Mycoplasma pneumonia in a public health laboratory . Health Lab Sci 4:90-95, 1967;.
16 +
Moody MD, et al:  Epidemiologic characterization of group A streptococci by T-agglutination and M-precipitation tests in the public health laboratory . Health Lab Sci 2:149-162, 1965;.
17 +
Anand SC, Itkin IH, Kind LS:  Effect of influenza vaccine on methacholine (Mecholyl) sensitivity in patients with asthma of known and unknown origin . J Allergy 42:187-192, 1968;.
18 +
Kumar L, Newcomb RW, Molk L:  Effect of live measles vaccine on bronchial sensitivity of asthmatic children to methacholine . J Allergy 45:104, 1970;.
19 +
Eisen AH:  The role of infection in allergic disease . Pediatr Clin North Am 16:67-83, 1969;.
20 +
Hendley JO, Edmondson WP Jr, Gwaltney JM Jr:  Relationship between naturally acquired immunity and infectivity of two rhinoviruses in volunteers . J Infect Dis 125:243-248, 1972;.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Ford RM:  Aetiology of asthma: A review of 11,551 cases (1958 to 1968) . Med J Aust 14:628-631, 1969;.
2 +
Williams H, McNicol KN:  Prevalence, natural history, and relationship of wheezy bronchitis and asthma in children: An epidemiological study . Br Med J 9:321-325, 1969;.
3 +
Sanders S, Normal AP:  The bacterial flora of the upper respiratory tract in children with severe asthma . J Allergy 41:319-325, 1968;.
4 +
Berman S, et al:  Transcricothyroid cultures in "infectious" asthma . J Allergy Clin Immunol 51:122, 1973;.
5 +
Berkovich S, Millain SJ, Snyder RD:  The association of viral and mycoplasma infections with the recurrence of wheezing in the asthmatic child . Ann Allergy 28:43-49, 1970;.
6 +
McIntosh K, et al:  The association of viral and bacterial respiratory infections with exacerbations of wheezing in young asthmatic children . J Pediatr 82:578-590, 1973;.
7 +
Dick EC, et al:  Viruses as precipitants of asthmatic attacks in children . Clin Res 20:799, 1972;.
8 +
Evans AS, Dick EC:  Acute pharyngitis and tonsillitis in University of Wisconsin students . JAMA 190:699-708, 1964;.
9 +
Cherry JD, Diddams JA, Dick EC:  Rhinovirus infections in hospitalized children: Provocative bacterial interrelationships . Arch Environ Health 14:390-396, 1967;.
10 +
Dick EC, Blumer CR, Evans AS:  Epidemiology of infections with rhinovirus types 43 and 55 in a group of University of Wisconsin student families . Am J Epidemiol 86:386-400, 1967;.
11 +
D'Alessio DJ, Cox PM, Dick EC:  Failure of inactivated influenza vaccine to protect an aged population . JAMA 210:485-489, 1969;.
12 +
Parker CD, Bilbo RE, Reed CE:  Methacholine aerosol as a test for bronchial asthma . Arch Intern Med 115:452-458, 1965;.
13 +
Ouellette JJ, Reed CE:  Increased response of asthmatic subjects to methacholine after influenza vaccine . J Allergy 36:558-563, 1965;.
14 +
Reed CE, Cohen M, Enta T:  Reduced effect of epinephrine on circulating eosinophils in asthma and after beta adrenergic blockade or Bordetella pertussis vaccine: With a note on eosinopenia after methacholine . J Allergy 46:90-102, 1970;.
15 +
Allen V, Sueltmann S, Lawson C:  Laboratory diagnosis of Mycoplasma pneumonia in a public health laboratory . Health Lab Sci 4:90-95, 1967;.
16 +
Moody MD, et al:  Epidemiologic characterization of group A streptococci by T-agglutination and M-precipitation tests in the public health laboratory . Health Lab Sci 2:149-162, 1965;.
17 +
Anand SC, Itkin IH, Kind LS:  Effect of influenza vaccine on methacholine (Mecholyl) sensitivity in patients with asthma of known and unknown origin . J Allergy 42:187-192, 1968;.
18 +
Kumar L, Newcomb RW, Molk L:  Effect of live measles vaccine on bronchial sensitivity of asthmatic children to methacholine . J Allergy 45:104, 1970;.
19 +
Eisen AH:  The role of infection in allergic disease . Pediatr Clin North Am 16:67-83, 1969;.
20 +
Hendley JO, Edmondson WP Jr, Gwaltney JM Jr:  Relationship between naturally acquired immunity and infectivity of two rhinoviruses in volunteers . J Infect Dis 125:243-248, 1972;.

Letters

Submit a Letter
CME Course for:


You need to register in order to view this quiz.


To understand the clinical management of acute heart failure syndromes.
Accreditation Information The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
To view and print your certificate and access a summary of your CME courses go to My CME.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Response

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

© 2012 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems