A/Hong Kong Influenza Immunity Three Years After Immunization FREE

Hjordis M. Foy, MD, PhD; Marion K. Cooney, MD; Ruth McMahan, MN

[+] Author Affiliations

Reprint requests to Department of Epidemiology and International Health (SC-36), School of Public Health and Community Medicine, University of Washington, Seattle 98195 (Dr. Foy).

JAMA. 1973;226(7):758-761. doi:10.1001/jama.1973.03230070024006

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ABSTRACT

ABSTRACT | REFERENCES

We studied influenza infection and disease in school children vaccinated with either 400 chick cell agglutination units of A/Hong Kong influenza virus vaccine or monovalent influenza virus vaccine type B (controls) in 1968, through the third A/Hong Kong influenza epidemic in January 1972, in Seattle.

During the three A/Hong Kong influenza epidemics (1968 to 1969, 1970, and 1972), the serologically determined infection rates among controls were 14%, 23%, and 26%. Only one of the 156 control subjects had serologic titer rises in two epidemics, suggesting that repeated A/Hong Kong influenza was rare. Based on serologic data and illness reports from 303 children observed during the 1972 epidemic, the A/Hong Kong influenza virus vaccine given three years earlier was still approximately 60% effective in preventing influenza. Considering that many control children had become naturally immune in the interim, true efficacy may have been higher. Vaccine-induced immunity was also reflected in lower rates of school absenteeism among the 1,516 students so studied.

REFERENCES

ABSTRACT | REFERENCES

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Dull HB, et al: Monovalent Asian influenza vaccine: Evaluation of its use during two waves of epidemic Asian influenza in partly immunized penitentiary population . JAMA 172:1223-1229, 1960;.

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Stuart WH, et al: Evaluation of monovalent influenza vaccine in a retirement community during the epidemic of 1965-1966 . JAMA 209:232-238, 1969;.

Foy HM, et al: Single-dose monovalent A2/Hong Kong influenza vaccine . JAMA 217:1067-1071, 1971;.

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Foy HM, et al: A field trial of Hong Kong strain influenza vaccine in Seattle schoolchildren . WHO Bull 41:564-566, 1969;.

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Foy HM, et al: Viral and mycoplasmal pneumonia in a prepaid medical care group over an eight year period . Am J Epidemiol 97:93-102, 1973;.

Murphy BR, Kasel JA, Chanock RM: Association of serum anti-neuraminidase antibody with resistance to influenza in man . N Engl J Med 286:1329-1332, 1972;.

Webster RG, Laver WG: Studies on the origin of pandemic influenza: I. Antigenic analysis of A2 influenza viruses isolated before and after the appearance of Hong Kong influenza using antisera to the isolated hemagglutinin subunits . Virology 48:433-444, 1972;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal