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July 16, 1973, Vol 225, No. 3 >
ARTICLE | July 16, 1973

Pituitary Ablation and Disseminated Prostatic Carcinoma FREE

Charles R. West, MD; Gerald P. Murphy, MD, DSc
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JAMA. 1973;225(3):253-256. doi:10.1001/jama.1973.03220300015003
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References

Twenty-seven patients with disseminated carcinoma of the prostate underwent adenohypophysectomy by either open craniotomy (8 patients) or stereotaxic cryohypophysectomy (19 patients). All patients had growth hormone assay following insulin-induced hypoglycemia during the preoperative (control) period and twice during the postoperative (experimental) period. In the postoperative tests, a 73% or greater suppression of growth hormone levels following hypoglycemia correlated with significant clinical remission and prolongation of survival. The minimal degree of growth hormone suppression consistent with clinical remission and extended survival was shown to be between 22% and 73% (as compared with preoperative control values). Subtotal hypophysectomy is adequate to achieve significant clinical remission and extended survival. Growth hormone assay is a useful index of the adequacy of hypophysectomy.

REFERENCES

1 +
Scott WW:  Endocrine management of disseminated prostatic cancer, including bilateral adrenalectomy and hypophysectomy . Trans Am Assoc Genitourin Surg 44:101-104, 1952;.
2 +
Luft R, Olivecrona H:  Hypophysectomy in the treatment of malignant tumors . Cancer 10:789-794, 1957;.
3 +
Murphy GP, et al:  Hypophysectomy for disseminated prostatic carcinoma . J Surg Oncol 1:81-95, 1969;.
4 +
Norrell H, et al:  A clinico-pathological analysis of cryohypophysectomy in patients with advanced cancer . Cancer 25:1050-1060, 1970;.
5 +
Murphy GP, et al:  Hypophysectomy and adrenalectomy for disseminated prostatic carcinoma . J Urol 105:817-825, 1971;.
6 +
Tytus JS, Ries L:  Further observations on rapid freezing and its possible applications to neurosurgical techniques . Bull Mason Clin 15:51-61, 1961;.
7 +
Conway LW, Collins WF:  Results of transsphenoidal cryohypophysectomy for carcinoma of the breast . N Engl J Med 281:1-7, 1969;.
8 +
Rand RW, et al:  Stereotactic cryohypophysectomy . JAMA 189:255-259, 1964;.
9 +
Maddy JA, Winternitz WW, Norrell H:  Cryohypophysectomy in the management of advanced prostatic cancer . Cancer 28:322-328, 1971;.
10 +
Babson AL, Philips GE:  An improved acid phosphatase procedure . Clin Chim Acta 13:264-265, 1966;.
11 +
Bowers GN, McComb RB:  A continuous spectrophotometric method for measuring the activity of serum alkaline phosphatase . Clin Chem 12:70-89, 1966;.
12 +
Garcia JF, et al:  Plasma growth hormone studies in normal individuals and acromegalic patients . J Clin Endocrinol Metab 27:1395-1402, 1967;.
13 +
Roth J, et al:  Hypoglycemia: A potent stimulus to secretion of growth hormone . Science 140:987-988, 1963;.
14 +
Scott WW, Schirmer HKA:  Hypophysectomy for disseminated prostatic cancer , in On Cancer and Hormones: Essays in Experimental Biology . University of Chicago Press, 1962;, pp 175-204.
15 +
Poppen JL: An Atlas of Neurosurgical Techniques . Philadelphia, WB Saunders Co, 1960;, p 522.
16 +
Sokolnikoff IS, Redheffer RM: Mathematics of Physics and Modern Engineering . New York, McGraw-Hill, 1958;, p 717.
17 +
Van Buren JM, Bergenstal DM:  An evaluation of graded hypophysectomy in man . Cancer 13:155-171, 1960;.
18 +
Fergusson JD, Phillips DEH:  A clinical evaluation of radioactive pituitary implantation in the treatment of advanced carcinoma of the prostate . Br J Urol 34:485-492, 1962;.
19 +
Luft R, Olivecrona H:  Hypophysectomy in the management of neoplastic disease . Bull NY Acad Med 33:5-16, 1957;.
20 +
Straffon RA:  Yttrium-90 hypophysectomy in the management of metastatic carcinoma of the prostate in 13 patients . J Urol 99:102-105, 1968;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Scott WW:  Endocrine management of disseminated prostatic cancer, including bilateral adrenalectomy and hypophysectomy . Trans Am Assoc Genitourin Surg 44:101-104, 1952;.
2 +
Luft R, Olivecrona H:  Hypophysectomy in the treatment of malignant tumors . Cancer 10:789-794, 1957;.
3 +
Murphy GP, et al:  Hypophysectomy for disseminated prostatic carcinoma . J Surg Oncol 1:81-95, 1969;.
4 +
Norrell H, et al:  A clinico-pathological analysis of cryohypophysectomy in patients with advanced cancer . Cancer 25:1050-1060, 1970;.
5 +
Murphy GP, et al:  Hypophysectomy and adrenalectomy for disseminated prostatic carcinoma . J Urol 105:817-825, 1971;.
6 +
Tytus JS, Ries L:  Further observations on rapid freezing and its possible applications to neurosurgical techniques . Bull Mason Clin 15:51-61, 1961;.
7 +
Conway LW, Collins WF:  Results of transsphenoidal cryohypophysectomy for carcinoma of the breast . N Engl J Med 281:1-7, 1969;.
8 +
Rand RW, et al:  Stereotactic cryohypophysectomy . JAMA 189:255-259, 1964;.
9 +
Maddy JA, Winternitz WW, Norrell H:  Cryohypophysectomy in the management of advanced prostatic cancer . Cancer 28:322-328, 1971;.
10 +
Babson AL, Philips GE:  An improved acid phosphatase procedure . Clin Chim Acta 13:264-265, 1966;.
11 +
Bowers GN, McComb RB:  A continuous spectrophotometric method for measuring the activity of serum alkaline phosphatase . Clin Chem 12:70-89, 1966;.
12 +
Garcia JF, et al:  Plasma growth hormone studies in normal individuals and acromegalic patients . J Clin Endocrinol Metab 27:1395-1402, 1967;.
13 +
Roth J, et al:  Hypoglycemia: A potent stimulus to secretion of growth hormone . Science 140:987-988, 1963;.
14 +
Scott WW, Schirmer HKA:  Hypophysectomy for disseminated prostatic cancer , in On Cancer and Hormones: Essays in Experimental Biology . University of Chicago Press, 1962;, pp 175-204.
15 +
Poppen JL: An Atlas of Neurosurgical Techniques . Philadelphia, WB Saunders Co, 1960;, p 522.
16 +
Sokolnikoff IS, Redheffer RM: Mathematics of Physics and Modern Engineering . New York, McGraw-Hill, 1958;, p 717.
17 +
Van Buren JM, Bergenstal DM:  An evaluation of graded hypophysectomy in man . Cancer 13:155-171, 1960;.
18 +
Fergusson JD, Phillips DEH:  A clinical evaluation of radioactive pituitary implantation in the treatment of advanced carcinoma of the prostate . Br J Urol 34:485-492, 1962;.
19 +
Luft R, Olivecrona H:  Hypophysectomy in the management of neoplastic disease . Bull NY Acad Med 33:5-16, 1957;.
20 +
Straffon RA:  Yttrium-90 hypophysectomy in the management of metastatic carcinoma of the prostate in 13 patients . J Urol 99:102-105, 1968;.

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