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July 2, 1973, Vol 225, No. 1 >
ARTICLE | July 2, 1973

Lomustine Treatment of Metastatic Renal Cell Carcinoma FREE

Arnold Mittelman, MD; David J. Albert, MD; Gerald P. Murphy, MD, DSc
[+] Author Affiliations

Reprint requests to Roswell Park Memorial Institute, 666 Elm St, Buffalo, NY 14203 (Dr. Mittelman).


JAMA. 1973;225(1):32-35. doi:10.1001/jama.1973.03220280022006
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References

The efficacy of lomustine (CCNU) therapy in metastatic renal cell carcinoma was studied in 23 patients. Only 20 of these cases could be evaluated, and, of these, four showed an objective remission lasting from three to six months. Hypercalcemia was controlled, pulmonary and soft tissue metastases regressed, and recalcification of lytic osseous metastases was noted. The condition of two other patients has been stable for more than six months. Minimal toxicity, such as transient early nausea and vomiting, was associated with drug administration. Moderate thrombocytopenia and mild leukopenia were seen in one third of all patients. Lomustine merits further clinical use in the treatment of advanced renal cell carcinoma.

REFERENCES

1 +
Silverberg E, Helleb A:  Cancer statistics 1972 . CA 22:2-20, 1972;.
2 +
Flocks RH, Kodesky MC:  Malignant neoplasms of the kidney: An analysis of 353 patients followed five years or more . J Urol 79:196-201, 1958;.
3 +
Creeny CD:  Confusing clinical manifestations of malignant renal neoplasms . Arch Intern Med 55:895-916, 1935;.
4 +
Bruce J, Macleod JG:  Long survival in renal carcinoma . Br Med J 1:1323, 1955;.
5 +
Walter CW, Gillespie DR:  Metastatic hypernephroma of 50 years' duration . Minn Med 43:123-125, 1960;.
6 +
Salm R, Pollok R:  A very slowly developing hypernephroma . Br Med J 2:266-267, 1952;.
7 +
Gordon FM, Bateson EM:  A renal adenocarcinoma with slow growing lung metastases present for eight years . Br J Radiol 35:425-429, 1962;.
8 +
Kay S:  Renal cell carcinoma: A ten year study . Am J Clin Pathol 50:428-432, 1968;.
9 +
Miller HC, Woodruff MW, Giambacorta JP:  Spontaneous regression of pulmonary metastases from hypernephroma . Ann Surg 156:852-856, 1962;.
10 +
Garfield DH, Kennedy BJ:  Regression of metastatic renal cell carcinoma following nephrectomy . Cancer 30:190-196, 1972;.
11 +
DeGiorgi LS:  Regression of pulmonary metastases during radiation to a hypernephroma: Immunity and cancer . Cancer 30:895-899, 1972;.
12 +
Ljunggren F:  Some aspects of renal tumors with special reference to spontaneous regression . J Urol 82:553-557, 1959;.
13 +
Bennington JL, Kradjion RM: Renal Carcinoma . Philadelphia, WB Saunders Co, 1967;, pp 156-160.
14 +
Bloom HJG:  Medroxyprogesterone acetate (Provera) in the treatment of metastatic renal cancer . Br J Cancer 25:250-265, 1971;.
15 +
Talley RH, et al:  Treatment of metastatic hypernephroma . JAMA 207:322-325, 1969;.
16 +
Wagle DG, Murphy GP:  Hormonal therapy in advanced renal cell carcinoma . Cancer 28:318-321, 1971;.
17 +
Murphy GP, Moore RH, Kenny GM:  Current results from primary and secondary treatment of renal cell carcinoma . J Urol 104:523-527, 1970;.
18 +
Everson TC, Cole WH: Spontaneous Regression of Cancer . Philadelphia, WB Saunders Co, 1966;, pp 11-87.
19 +
Hansen HH, et al:  Clinical studies with 1-(2-chloroethyl)-3-cyclohexl-l-nitrosourea . Cancer Res 31:223-227, 1971;.
20 +
Cheng JC, et al:  Interaction of 1-(2-chloroethyl)-3-cyclohexl-l-nitrosourea (NSC 79037) with nucleic acids and proteins in vivo and in vitro . Cancer Res 32:22-27, 1972;.
21 +
Moertel CG, et al:  A phase II study of 1-(2-chloroethyl)-3-cyclohexl-l-nitrosourea (NSC 9037) in the palliative management of advanced gastrointestinal cancer . Cancer Res 32:1278-1279, 1972;.
22 +
Woodruff MW, et al:  The current status of chemotherapy for advanced renal cell carcinoma . J Urol 97:611-618, 1967;.

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1 +
Silverberg E, Helleb A:  Cancer statistics 1972 . CA 22:2-20, 1972;.
2 +
Flocks RH, Kodesky MC:  Malignant neoplasms of the kidney: An analysis of 353 patients followed five years or more . J Urol 79:196-201, 1958;.
3 +
Creeny CD:  Confusing clinical manifestations of malignant renal neoplasms . Arch Intern Med 55:895-916, 1935;.
4 +
Bruce J, Macleod JG:  Long survival in renal carcinoma . Br Med J 1:1323, 1955;.
5 +
Walter CW, Gillespie DR:  Metastatic hypernephroma of 50 years' duration . Minn Med 43:123-125, 1960;.
6 +
Salm R, Pollok R:  A very slowly developing hypernephroma . Br Med J 2:266-267, 1952;.
7 +
Gordon FM, Bateson EM:  A renal adenocarcinoma with slow growing lung metastases present for eight years . Br J Radiol 35:425-429, 1962;.
8 +
Kay S:  Renal cell carcinoma: A ten year study . Am J Clin Pathol 50:428-432, 1968;.
9 +
Miller HC, Woodruff MW, Giambacorta JP:  Spontaneous regression of pulmonary metastases from hypernephroma . Ann Surg 156:852-856, 1962;.
10 +
Garfield DH, Kennedy BJ:  Regression of metastatic renal cell carcinoma following nephrectomy . Cancer 30:190-196, 1972;.
11 +
DeGiorgi LS:  Regression of pulmonary metastases during radiation to a hypernephroma: Immunity and cancer . Cancer 30:895-899, 1972;.
12 +
Ljunggren F:  Some aspects of renal tumors with special reference to spontaneous regression . J Urol 82:553-557, 1959;.
13 +
Bennington JL, Kradjion RM: Renal Carcinoma . Philadelphia, WB Saunders Co, 1967;, pp 156-160.
14 +
Bloom HJG:  Medroxyprogesterone acetate (Provera) in the treatment of metastatic renal cancer . Br J Cancer 25:250-265, 1971;.
15 +
Talley RH, et al:  Treatment of metastatic hypernephroma . JAMA 207:322-325, 1969;.
16 +
Wagle DG, Murphy GP:  Hormonal therapy in advanced renal cell carcinoma . Cancer 28:318-321, 1971;.
17 +
Murphy GP, Moore RH, Kenny GM:  Current results from primary and secondary treatment of renal cell carcinoma . J Urol 104:523-527, 1970;.
18 +
Everson TC, Cole WH: Spontaneous Regression of Cancer . Philadelphia, WB Saunders Co, 1966;, pp 11-87.
19 +
Hansen HH, et al:  Clinical studies with 1-(2-chloroethyl)-3-cyclohexl-l-nitrosourea . Cancer Res 31:223-227, 1971;.
20 +
Cheng JC, et al:  Interaction of 1-(2-chloroethyl)-3-cyclohexl-l-nitrosourea (NSC 79037) with nucleic acids and proteins in vivo and in vitro . Cancer Res 32:22-27, 1972;.
21 +
Moertel CG, et al:  A phase II study of 1-(2-chloroethyl)-3-cyclohexl-l-nitrosourea (NSC 9037) in the palliative management of advanced gastrointestinal cancer . Cancer Res 32:1278-1279, 1972;.
22 +
Woodruff MW, et al:  The current status of chemotherapy for advanced renal cell carcinoma . J Urol 97:611-618, 1967;.

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