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June 18, 1973, Vol 224, No. 12 >
ARTICLE | June 18, 1973

Nondysenteric Intestinal Amebiasis: Title and subTitle BreakTreatment With Diloxanide Furoate FREE

Martin S. Wolfe, MD
[+] Author Affiliations

Read in part before the 20th annual meeting of the American Society of Tropical Medicine and Hygiene, Boston, Dec 3, 1971.

Reprint requests to Office of Medical Services, Department of State, Washington, DC 20520 (Dr. Wolfe).


JAMA. 1973;224(12):1601-1604. doi:10.1001/jama.1973.03220260021005
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References

Diloxanide furoate, an investigational, amebicidal drug in the United States, was given in a ten-day course of 500 mg three times a day. This therapy led to parasitologic and symptomatic cure in all 12 asymptomatic cyst carriers and in 52 of 65 patients with nondysenteric, symptomatic, intestinal amebiasis who had all contracted Entamoeba histolytica infections while abroad. Criteria for cure were the absence of E histolytica parasites in three complete stool examinations, one and three months following completion of treatment, and complete or marked symptomatic improvement. Excessive flatulence was a common, but the only significant side effect. The high effectiveness (83% cure rate), relative ease of administration, and minimal toxicity of diloxanide furoate indicates that this drug has numerous advantages over other primarily luminal-acting amebicides presently available in this country for the treatment of chronic amebiasis.

REFERENCES

1 +
Woodruff AW, Bell S:  The evaluation of amoebicides . Trans R Soc Trop Med Hyg 61:435-439, 1967;.
2 +
Felix H, et al:  Treatment of amoebiasis with entamide furoate . Bull Soc Pathol Exot 55:370-379, 1962;.
3 +
Botero D:  Treatment of acute and chronic intestinal amebiasis with entamide furoate . Trans R Soc Trop Med Hyg 58:419-421, 1964;.
4 +
Wilmot AJ, et al:  Some newer amoebicides in acute amoebic dysentery . Trans R Soc Trop Med Hyg 56:85-86, 1962;.
5 +
Seaton DR:  Amoebicides . Gut 206:16-19, 1971;.
6 +
Marsden PD, Schultz MG:  Intestinal parasites . Gastroenterology 57:724-750, 1969;.
7 +
Sapero JJ, Lawless DK:  The "MIF" stainpreservation technique for the identification of intestinal protozoa . Am J Trop Med Hyg 2:613-619, 1953;.
8 +
Woodruff AW, Bell S:  Clinical trials with entamide furoate and related compounds: I. In a non-tropical environment . Trans R Soc Trop Med Hyg 54:389-395, 1960;.
9 +
Powell SJ:  Short-term followup studies in amoebic dysentery . Trans R Soc Trop Med Hyg 61:765-768, 1967;.
10 +
Most H:  Current concepts in therapy: Treatment of amebiasis . N Engl J Med 262:513-514, 1960;.
11 +
Schultz MG:  Entero-Vioform for preventing travelers' diarrhea , editorial. JAMA 220273-274, 1972;.
12 +
 Annotations: Clioquinol and other halogenated hydroxyquinolines . Lancet 1:679, 1968;.
13 +
Sodeman WA Jr:  Amebiasis (clinical seminar) . Am J Dig Dis 16:51-60, 1971;.
14 +
Keusch GT, et al:  Malabsorption due to paromomycin . Arch Intern Med 125273-276, 1970;.
15 +
Radke RA, Baroody WG:  Carbarsone toxicity: A review of the literature and report of 45 cases . Ann Intern Med 47:418-427, 1957;.
16 +
 Today's drugs: Drugs for dysentery . Br Med J 1:825-828, 1964;.
17 +
Powell SJ:  Drug therapy of amoebiasis . Bull WHO 40:953-956, 1969;.
18 +
Khambatta RB:  Metronidazole and the "symptomless cyst-passer." Med Today 3:72-74, 1969;.
19 +
Chuttani PN, et al:  The cyst passer . Indian Practitioner 21:714-718, 1968;.
20 +
Chongsuphajaisiddhi T, et al:  Treatment of Entamoeba histolytica cyst passers with metronidazole . Southeast Asian J Trop Med Public Health 229-33, 1971;.
21 +
Kanani SR, Knight R:  Experiences with the use of metronidazole in the treatment of non-dysenteric intestinal amoebiasis . Trans R Soc Trop Med Hyg 66:244-249, 1972;.
22 +
Powell SJ, Elsdon-Dew R:  Chloroquine in amoebic dysentery . Trans R Soc Trop Med Hyg 65:540, 1971;.
23 +
Weber DM:  Amebic abscess of liver following metronidazole therapy . JAMA 216:1339-1340, 1971;.

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1 +
Woodruff AW, Bell S:  The evaluation of amoebicides . Trans R Soc Trop Med Hyg 61:435-439, 1967;.
2 +
Felix H, et al:  Treatment of amoebiasis with entamide furoate . Bull Soc Pathol Exot 55:370-379, 1962;.
3 +
Botero D:  Treatment of acute and chronic intestinal amebiasis with entamide furoate . Trans R Soc Trop Med Hyg 58:419-421, 1964;.
4 +
Wilmot AJ, et al:  Some newer amoebicides in acute amoebic dysentery . Trans R Soc Trop Med Hyg 56:85-86, 1962;.
5 +
Seaton DR:  Amoebicides . Gut 206:16-19, 1971;.
6 +
Marsden PD, Schultz MG:  Intestinal parasites . Gastroenterology 57:724-750, 1969;.
7 +
Sapero JJ, Lawless DK:  The "MIF" stainpreservation technique for the identification of intestinal protozoa . Am J Trop Med Hyg 2:613-619, 1953;.
8 +
Woodruff AW, Bell S:  Clinical trials with entamide furoate and related compounds: I. In a non-tropical environment . Trans R Soc Trop Med Hyg 54:389-395, 1960;.
9 +
Powell SJ:  Short-term followup studies in amoebic dysentery . Trans R Soc Trop Med Hyg 61:765-768, 1967;.
10 +
Most H:  Current concepts in therapy: Treatment of amebiasis . N Engl J Med 262:513-514, 1960;.
11 +
Schultz MG:  Entero-Vioform for preventing travelers' diarrhea , editorial. JAMA 220273-274, 1972;.
12 +
 Annotations: Clioquinol and other halogenated hydroxyquinolines . Lancet 1:679, 1968;.
13 +
Sodeman WA Jr:  Amebiasis (clinical seminar) . Am J Dig Dis 16:51-60, 1971;.
14 +
Keusch GT, et al:  Malabsorption due to paromomycin . Arch Intern Med 125273-276, 1970;.
15 +
Radke RA, Baroody WG:  Carbarsone toxicity: A review of the literature and report of 45 cases . Ann Intern Med 47:418-427, 1957;.
16 +
 Today's drugs: Drugs for dysentery . Br Med J 1:825-828, 1964;.
17 +
Powell SJ:  Drug therapy of amoebiasis . Bull WHO 40:953-956, 1969;.
18 +
Khambatta RB:  Metronidazole and the "symptomless cyst-passer." Med Today 3:72-74, 1969;.
19 +
Chuttani PN, et al:  The cyst passer . Indian Practitioner 21:714-718, 1968;.
20 +
Chongsuphajaisiddhi T, et al:  Treatment of Entamoeba histolytica cyst passers with metronidazole . Southeast Asian J Trop Med Public Health 229-33, 1971;.
21 +
Kanani SR, Knight R:  Experiences with the use of metronidazole in the treatment of non-dysenteric intestinal amoebiasis . Trans R Soc Trop Med Hyg 66:244-249, 1972;.
22 +
Powell SJ, Elsdon-Dew R:  Chloroquine in amoebic dysentery . Trans R Soc Trop Med Hyg 65:540, 1971;.
23 +
Weber DM:  Amebic abscess of liver following metronidazole therapy . JAMA 216:1339-1340, 1971;.

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