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November 6, 1972, Vol 222, No. 6 >
ARTICLE | November 6, 1972

Postprandial Drowsiness FREE

Eduardo H. Rubinstein, MD, PhD
JAMA. 1972;222(6):703-703. doi:10.1001/jama.1972.03210060053019
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References

To the Editor.—  The problem of the postprandial drowsiness outlined by Dr. Kleitman (219:1485, 1972) prompted successive letters by Drs. Hauri (220:1135, 1972) and Regenstein (221:601, 1972). I would like now. to introduce another factor for consideration: the possible role of the intestinal hormones.1The presence of food in the gut releases intestinal hormones: cholecystokinin (CCK) and secretin.2 Our observations3 indicated that during the period of release, the incidence of sleep (in the cat) was significantly increased. Also, the intraduodenal instillation of small amounts of releasing agents, eg, corn oil, was followed, after a variable latency, by sleep with rapid eye movement (REM) periods of earlier onset and longer duration than average. Moreover, the intravenous infusion of the intestinal hormones, especially cholecystokinin, was associated, during the one-hour infusion, with long-lasting episodes of deep and REM sleep. This effect of the hormones varied depending on the time of

REFERENCES

1 +
Fara JW, Rubinstein EH, Sonnenschein RR:  Visceral and behavioral responses to intraduodenal fat . Science 166:110-111, 1969;.
2 +
Wang CC, Grossman MI:  Physiological determination of the release of secretin and pancreozymin from the intestine of dogs with transplanted pancreas . Am J Physiol 164:527-545, 1951;.
3 +
Rubinstein EH,  Sonnenschein RR: Sleep cycles and feeding behavior in the cat. Role of gastrointestinal hormones . Acta Cient Venez 22( (suppl 2) ):125-128, 1971;.
4 +
Hartmann E, Chung R, Chien C:  L-tryptophane and sleep . Psychopharmacologia 19:114-127, 1971;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Fara JW, Rubinstein EH, Sonnenschein RR:  Visceral and behavioral responses to intraduodenal fat . Science 166:110-111, 1969;.
2 +
Wang CC, Grossman MI:  Physiological determination of the release of secretin and pancreozymin from the intestine of dogs with transplanted pancreas . Am J Physiol 164:527-545, 1951;.
3 +
Rubinstein EH,  Sonnenschein RR: Sleep cycles and feeding behavior in the cat. Role of gastrointestinal hormones . Acta Cient Venez 22( (suppl 2) ):125-128, 1971;.
4 +
Hartmann E, Chung R, Chien C:  L-tryptophane and sleep . Psychopharmacologia 19:114-127, 1971;.

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