Absorption of Orally Given Digoxin Preparations FREE

David H. Huffman, MD; Daniel L. Azarnoff, MD

[+] Author Affiliations

Reprint requests to University of Kansas Medical Center, 39th St and Rainbow Blvd, Kansas City, Kan 66103 (Dr. Huffman).

JAMA. 1972;222(8):957-960. doi:10.1001/jama.1972.03210080037011

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References

ABSTRACT

ABSTRACT | REFERENCES

Digoxin absorption has been studied in four normal volunteers. Whereas the digoxin (Lanoxin) administered in an oral solution is completely absorbed, that in tablet form is only 75% absorbed. These results are obtained from the cumulative urinary excretion of digoxin rather than serum digoxin concentration curves since the digoxin radioimmunoassay is not sensitive enough to obtain valid data by the latter method. Since digoxin has a steep dose-response curve, a reduction in digoxin dosage is necessary when changing from oral tablet to parenteral administration to avoid the development of digoxin toxicity.

REFERENCES

ABSTRACT | REFERENCES

Lindenbaum J, et al: Variation in biological availability of digoxin from four preparations . N Engl J Med 285:1344-1347, 1971;.

Moe GK, Farah AE: Digitalis and allied cardiac glycosides , in Goodman LS, Gilman A (eds.): The Pharmacological Basis of Therapeutics , ed 4. New York, Macmillan Co, 1970;, pp 677-708.

Doherty JE, et al: Tritiated digoxin: XIV. Enterohepatic circulation, absorption, and excretion studies in human volunteers . Circulation 42:867-873, 1970;.

Friedberg CK: Diseases of Heart , ed 3. Philadelphia, WB Saunders Co, 1966;, pp 367-368.

Smith TW, Butler VP Jr, Haber E: Determination of therapeutic and toxic serum digoxin concentrations by radioimmunoassay . N Engl J Med 281:1212-1216, 1969;.

Wagner JG, Nelson E: The kinetic analysis of blood levels and urinary excretion in the absorptive phases after single doses of drugs . J Pharm Sci 53:1392-1403, 1964;.

Levy G, Tsuchriya T: Effect of activated charcoal on aspirin absorption in man . Clin Pharmacol Ther 13:317-322, 1972;.

Wagner JG: Biopharmaceutics and Relevant Pharmacokinetics , ed 1. Hamilton, Ill, Drug Intelligence Publications, 1971;, pp 180-190.

Doherty JE: Determinants of digitalis dose . J Arkansas Med Soc 66:121-126, 1969;.

Hall WH, Doherty JE, Dalrymple GV: 'HDigoxin turnover in steatorrhea . Clin Res 20:455, 1972;.

Heizer WD, Smith TW, Goldfinger SE: Absorption of digoxin in patients with malabsorption syndromes . N Engl J Med 285:257-259, 1971;.

Thompson AJ, et al: Experimental myocardial infarction, serum levels and tissue concentration of 3H digoxin . Clin Res 20:401, 1972;.

Doherty JE, Perkins WH, Flanigan WJ: The distribution and concentration of tritiated digoxin in human tissues . Ann Intern Med 66:116-124, 1967;.

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