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ARTICLE |

Early Recognition of Chronic Airway Disease by the 133Xe Lung Scan FREE

Frank A. Dittrich, MD; David A. Goodwin, MD
[+] Author Affiliations

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JAMA. 1972;220(8):1120-1122. doi:10.1001/jama.1972.03200080062016
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Early airway disease, when it involves only the small peripheral airways, may not contribute sufficiently to airway resistance to be measured by the standard tests of ventilatory function. The133Xe lung scan is a relatively simple method for demonstrating maldistribution of regional ventilation caused by small-airway disease. In the case reported here, regional ventilation abnormalities were demonstrated with the133Xe lung scan, when the results of standard tests of pulmonary function were essentially normal.

REFERENCES

Hogg JC, Macklem PT, Thurlbeck WM:  Site and nature of airway obstruction in chronic obstructive lung disease . New Eng J Med 278:1355-1360, 1968;.
Woolcock AJ, Vincent NJ, Macklem PT:  Frequency dependence of compliance as a test for obstruction in the small airways . J Clin Invest 48:1097-1106, 1969;.
Fallat RJ, Powell MR:  Ventilation abnormalities in alpha, antitrypsin deficiency . J Nucl Med 11:318, 1970;.
Bell RL, De Nardo GL:  Enhanced scintigraphic information display using computergenerated ratio techniques . J Nucl Med 11:655-659, 1970;.
De Nardo GL, Goodwin DA, Ravasini R, et al:  The ventilatory lung scan in the diagnosis of pulmonary embolism . New Eng J Med 282:1334-1336, 1970;.
Medina JR, L'Heureux P, Lillehei JP, et al:  Regional ventilation in the differential diagnosis of pulmonary embolism . Circulation 39:831-835, 1969;.
Turner JM, Mead J, Wohl ME:  Elasticity of human lungs in relation to age . J Appl Physiol 25:664-671, 1968;.
Kueppers F:  Genetically determined differences in the response of alpha, antitrypsin levels in human serum to typhoid vaccine . Humangenetik 6:207-214, 1968;.
Falk GA, Siskind GW, Smith JP Jr:  Chronic obstructive pulmonary disease: A subgroup of patients identified by serum alpha, antitrypsin and immunoglobulin concentrations . Amer Rev Resp Dis 103:18-25, 1971;.
Kueppers F, Fallat R, Larson RK:  Obstructive lung disease and alpha, antitrypsin deficiency gene heterozygosity . Science 165:899-901, 1969;.
Boren HG, Cory RC, Snyder JC:  Veterans Administration—army cooperative study of pulmonary function . Amer J Med 41:96-114, 1966;.

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Hogg JC, Macklem PT, Thurlbeck WM:  Site and nature of airway obstruction in chronic obstructive lung disease . New Eng J Med 278:1355-1360, 1968;.
Woolcock AJ, Vincent NJ, Macklem PT:  Frequency dependence of compliance as a test for obstruction in the small airways . J Clin Invest 48:1097-1106, 1969;.
Fallat RJ, Powell MR:  Ventilation abnormalities in alpha, antitrypsin deficiency . J Nucl Med 11:318, 1970;.
Bell RL, De Nardo GL:  Enhanced scintigraphic information display using computergenerated ratio techniques . J Nucl Med 11:655-659, 1970;.
De Nardo GL, Goodwin DA, Ravasini R, et al:  The ventilatory lung scan in the diagnosis of pulmonary embolism . New Eng J Med 282:1334-1336, 1970;.
Medina JR, L'Heureux P, Lillehei JP, et al:  Regional ventilation in the differential diagnosis of pulmonary embolism . Circulation 39:831-835, 1969;.
Turner JM, Mead J, Wohl ME:  Elasticity of human lungs in relation to age . J Appl Physiol 25:664-671, 1968;.
Kueppers F:  Genetically determined differences in the response of alpha, antitrypsin levels in human serum to typhoid vaccine . Humangenetik 6:207-214, 1968;.
Falk GA, Siskind GW, Smith JP Jr:  Chronic obstructive pulmonary disease: A subgroup of patients identified by serum alpha, antitrypsin and immunoglobulin concentrations . Amer Rev Resp Dis 103:18-25, 1971;.
Kueppers F, Fallat R, Larson RK:  Obstructive lung disease and alpha, antitrypsin deficiency gene heterozygosity . Science 165:899-901, 1969;.
Boren HG, Cory RC, Snyder JC:  Veterans Administration—army cooperative study of pulmonary function . Amer J Med 41:96-114, 1966;.
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