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ARTICLE |

Evaluation of γ-Glutamyl Transpeptidase in Myocardial Infarction FREE

Eugene L. Coodley, MD
[+] Author Affiliations

Reprint requests to Philadelphia General Hospital, Civic Center Boulevard, Philadelphia 19104 (Dr. Coodley).


JAMA. 1972;220(2):217-219. doi:10.1001/jama.1972.03200020035009
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The activity of γ-glutamyl transpeptidase (γ-GTP) was determined serially in 64 patients with suspected myocardial infarction. Of 38 patients with proved myocardial infarction, only four showed early change of y-GTP activity and six showed change between the fifth and seventh day. Of 26 patients shown not to have myocardial infarction, slightly over one-third had persistent false-positive elevation of γ-GTP. These studies failed to demonstrate a significant value to this enzyme determination.

REFERENCES

Agostoni A, Ideo F, Stabilini R:  Serum γ-glutamyl-transpeptidase activity in myocardial infarction . Brit Heart J 27:688-703, 1965;.
Hedworth-Whitty RB, Whitefield FB, Richardson RW:  Serum γ-glutamyl-transpeptidase activity in myocardial ischemia . Brit Heart J 29:432-438, 1967;.
Ravens KG, Gudbjarnason S, Cowan CM, et al:  γ-glutamyl-transpeptidase in myocardial infarction: Clinical and experimental studies . Circulation 39:693-701, 1969;.
Coodley EL:  Enzyme diagnosis in cardiovascular disease . Amer J Med Sci 252:633-638, 1966;.
Coodley EL:  Clinical enzymology . Med Times , 1965;, pp 43-50.
Coodley EL:  Evaluation of enzyme diagnosis in myocardial infarction . Amer J Med Sci 256:300-305, 1968;.
Orlowski M, Szewczuk A:  Determination of γ-glutamyl-transpeptidase activity in human serum and urine . Clin Chim Acta 7:755-762, 1962;.
Orlowski M, Szewczuk A:  Note on the occurrence of γ-glutamyl-transpeptidase in human serum . Clin Chim Acta 6:430-436, 1960;.
Bratton AC, Marshall EK:  New coupling component for sulfanilamide determinations . J Biol Chem 128:537-543, 1939;.
Goldbarg JA, Pineda EP, Smith EE, et al:  A method for colorimetric determination of γ-glutamyl transpeptidase in human serum: Enzymatic activity in health and disease . Gastroenterology 44:127-132, 1963;.
Szczeklik E, Orlowski M, Szewczuk A:  Serum γ-glutamyl transpeptidase activity in liver disease . Gastroenterology 41:353-361, 1961;.
Kokot F, Kuska J:  Heterogeneity of serum γ-glutamyl transpeptidase in different internal diseases studied by starch gel electrophoresis and sephadex filtration . Enzym Biol Clin 9:59-67, 1968;.

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Agostoni A, Ideo F, Stabilini R:  Serum γ-glutamyl-transpeptidase activity in myocardial infarction . Brit Heart J 27:688-703, 1965;.
Hedworth-Whitty RB, Whitefield FB, Richardson RW:  Serum γ-glutamyl-transpeptidase activity in myocardial ischemia . Brit Heart J 29:432-438, 1967;.
Ravens KG, Gudbjarnason S, Cowan CM, et al:  γ-glutamyl-transpeptidase in myocardial infarction: Clinical and experimental studies . Circulation 39:693-701, 1969;.
Coodley EL:  Enzyme diagnosis in cardiovascular disease . Amer J Med Sci 252:633-638, 1966;.
Coodley EL:  Clinical enzymology . Med Times , 1965;, pp 43-50.
Coodley EL:  Evaluation of enzyme diagnosis in myocardial infarction . Amer J Med Sci 256:300-305, 1968;.
Orlowski M, Szewczuk A:  Determination of γ-glutamyl-transpeptidase activity in human serum and urine . Clin Chim Acta 7:755-762, 1962;.
Orlowski M, Szewczuk A:  Note on the occurrence of γ-glutamyl-transpeptidase in human serum . Clin Chim Acta 6:430-436, 1960;.
Bratton AC, Marshall EK:  New coupling component for sulfanilamide determinations . J Biol Chem 128:537-543, 1939;.
Goldbarg JA, Pineda EP, Smith EE, et al:  A method for colorimetric determination of γ-glutamyl transpeptidase in human serum: Enzymatic activity in health and disease . Gastroenterology 44:127-132, 1963;.
Szczeklik E, Orlowski M, Szewczuk A:  Serum γ-glutamyl transpeptidase activity in liver disease . Gastroenterology 41:353-361, 1961;.
Kokot F, Kuska J:  Heterogeneity of serum γ-glutamyl transpeptidase in different internal diseases studied by starch gel electrophoresis and sephadex filtration . Enzym Biol Clin 9:59-67, 1968;.
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