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ARTICLE |

Chronic Granulomatous Disease of Childhood in a 23-Year-Old Man FREE

Henry H. Balfour, Jr., MD; James J. Shehan, MDLt Col ; Carl E. Speicher, MC; Emanuel Kauder, MD
[+] Author Affiliations

The views expressed herein are those of the authors and do not necessarily reflect those of the US Air Force or Department of Defense.

Reprint requests to Box 437 Mayo Memorial, Minneapolis 55455 (Dr. Balfour).


JAMA. 1971;217(7):960-961. doi:10.1001/jama.1971.03190070068022
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A 23-year-old man with a history of recurrent bacterial and fungal infections since age 12 was shown to have a functional leukocyte defect similar to that found in children with chronic granulomatous disease. A liver biopsy revealed discrete granulomata. The documentation of this case calls attention to the possibility that there may be a mild form of chronic granulomatous disease and that recurrent bacterial infection in the adult may be due to a functional disorder of polymorphonuclear leukocytes.

REFERENCES

Johnston Jr RB, McMurry JS:  Chronic familial granulomatosis . Amer J Dis Child 114:370-378, 1967;.
Holmes B, Quie PG, Windhorst DB, et al:  Fatal granulomatous disease of childhood . Lancet 1:1225-1228, 1966;.
Oh MHK, Rodey GE, Good RA, et al:  Defective candidacidal capacity of polymorphonuclear leukocytes in chronic granulomatous disease of childhood . J Pediat 75:300-303, 1969;.
MacFarlane PS, Speirs AL, Sommerville RG:  Fatal granulomatous disease of childhood and benign lymphocytic infiltration of the skin (congenital dysphagocytosis) . Lancet 1:408-410, 1967;.
Windhorst DB, Holmes B, Good RA:  A newly defined x-linked trait in man with demonstration of the Lyon effect in carrier females . Lancet 1:737-739, 1967;.
Cooper MR, Dechatelet LR, Lavia MF, et al:  Complete deficiency of leukocyte glucose-6-phosphate dehydrogenase with defective bactericidal activity abstracted . J Clin Invest 49:21a, 1970;.
Thompson EN, Soothill JF:  Chronic granulomatous disease: Quantitative clinicopathological relationships . Arch Dis Child 45:24-32, 1970;.
Klebanoff SJ, White LR:  Iodination defect in the leukocytes of a patient with chronic granulomatous disease of childhood . New Eng J Med 280:460-466, 1969;.
Mandell GL, Hook EW:  Leukocyte bactericidal activity in chronic granulomatous disease: Correlation of bacterial hydrogen peroxide production and susceptibility to intracellular killing . J Bact 100:-531-532, 1969;.
Quie PG, Kaplan EL, Page AR, et al:  Defective polymorphonuclear-leukocyte function and chronic granulomatous disease in two female children . New Eng J Med 278:976-980, 1968;.
Douglas SD, Davis WC, Fudenberg HH:  Granulocytopathies: Pleomorphism of neutrophil dysfunction . Amer J Med 46:901-909, 1969;.

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Johnston Jr RB, McMurry JS:  Chronic familial granulomatosis . Amer J Dis Child 114:370-378, 1967;.
Holmes B, Quie PG, Windhorst DB, et al:  Fatal granulomatous disease of childhood . Lancet 1:1225-1228, 1966;.
Oh MHK, Rodey GE, Good RA, et al:  Defective candidacidal capacity of polymorphonuclear leukocytes in chronic granulomatous disease of childhood . J Pediat 75:300-303, 1969;.
MacFarlane PS, Speirs AL, Sommerville RG:  Fatal granulomatous disease of childhood and benign lymphocytic infiltration of the skin (congenital dysphagocytosis) . Lancet 1:408-410, 1967;.
Windhorst DB, Holmes B, Good RA:  A newly defined x-linked trait in man with demonstration of the Lyon effect in carrier females . Lancet 1:737-739, 1967;.
Cooper MR, Dechatelet LR, Lavia MF, et al:  Complete deficiency of leukocyte glucose-6-phosphate dehydrogenase with defective bactericidal activity abstracted . J Clin Invest 49:21a, 1970;.
Thompson EN, Soothill JF:  Chronic granulomatous disease: Quantitative clinicopathological relationships . Arch Dis Child 45:24-32, 1970;.
Klebanoff SJ, White LR:  Iodination defect in the leukocytes of a patient with chronic granulomatous disease of childhood . New Eng J Med 280:460-466, 1969;.
Mandell GL, Hook EW:  Leukocyte bactericidal activity in chronic granulomatous disease: Correlation of bacterial hydrogen peroxide production and susceptibility to intracellular killing . J Bact 100:-531-532, 1969;.
Quie PG, Kaplan EL, Page AR, et al:  Defective polymorphonuclear-leukocyte function and chronic granulomatous disease in two female children . New Eng J Med 278:976-980, 1968;.
Douglas SD, Davis WC, Fudenberg HH:  Granulocytopathies: Pleomorphism of neutrophil dysfunction . Amer J Med 46:901-909, 1969;.
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