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ARTICLE |

Herpesvirus Antibody and Carcinoma in Situ of the Cervix FREE

Louis W. Catalano, Jr., MD; Lorna D. Johnson, MD
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JAMA. 1971;217(4):447-450. doi:10.1001/jama.1971.03190040041008
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Herpesvirus hominis type 2 antibodies were present in 35.7% of patients who subsequently developed carcinoma in situ of the cervix, whereas type 2 antibodies were present in 7.1% of matched controls who did not develop carcinoma in situ during the same period of observation. Type 2 antibodies were present in a significantly greater percent of patients with carcinoma in situ (42.0) than matched controls (17.7). After cervical conization and presumptive cure of carcinoma in situ, however, type 2 antibodies were present in a smaller percent of patients (9.1) than matched controls (31.8). The data suggests that previous herpesvirus type 2 infection is associated not only with the precursory stages of invasive cancer, but also precedes the earliest intraepithelial changes which develop into carcinoma in situ.

REFERENCES

Rawls WE, Tomkins WAF, Figueroa ME, et al:  Herpesvirus type 2: Association with carcinoma of the cervix . Science 161:1255-1256, 1968;.
Rawls WE, Tomkins WAF, Melnick JL:  The association of herpesvirus type 2 and carcinoma of the uterine cervix . Amer J Epidem 89:547-554, 1969;.
Johnson LD:  The histopathologic approach to early cervical neoplasia . Obstet Gynec Survey 24:735-767, 1969;.
White LR, Sever JL, Alepa FP:  Maternal and congenital rubella before 1964: Frequency, clinical features, and search for isoimmune phenomena . J Pediat 74: 198-207, 1969;.
Bellanti JA, Catalano LW Jr, Chambers RW:  Herpes simplex encephalitis: Virologic and serologic study of a patient treated with an interferon inducer . J Pediat 78:136-145, 1971;.
Terris M:  Epidemiology of cancer of the cervix , in Lewis GC, Wertz WB, Jaffe RM, (eds): New Concepts in Gynecological Oncology . Philadelphia, FA Davis Co, 1968;, p 3.
Rotkin ID:  Sexual characteristics of a cervical cancer population . Amer J Public Health 57:815-829, 1967;.
Nahmias AJ, Josey WE, Naib ZM, et al:  Antibodies to Herpesvirus hominis types 1 and 2 in humans: II. Women with cervical cancer . Amer J Epidem 91:547-552, 1970;.
Royston I, Aurelian L:  Association of genital herpesvirus with cervical atypia and carcinoma in situ . Amer J Epidem 91:531-538, 1970;.
Johnson LD, Nickerson RJ, Easterday CL, et al:  Epidemiologic evidence for the spectrum of change from dysplasia through carcinoma in situ to invasive cancer . Cancer 22:901-914, 1968;.

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Rawls WE, Tomkins WAF, Figueroa ME, et al:  Herpesvirus type 2: Association with carcinoma of the cervix . Science 161:1255-1256, 1968;.
Rawls WE, Tomkins WAF, Melnick JL:  The association of herpesvirus type 2 and carcinoma of the uterine cervix . Amer J Epidem 89:547-554, 1969;.
Johnson LD:  The histopathologic approach to early cervical neoplasia . Obstet Gynec Survey 24:735-767, 1969;.
White LR, Sever JL, Alepa FP:  Maternal and congenital rubella before 1964: Frequency, clinical features, and search for isoimmune phenomena . J Pediat 74: 198-207, 1969;.
Bellanti JA, Catalano LW Jr, Chambers RW:  Herpes simplex encephalitis: Virologic and serologic study of a patient treated with an interferon inducer . J Pediat 78:136-145, 1971;.
Terris M:  Epidemiology of cancer of the cervix , in Lewis GC, Wertz WB, Jaffe RM, (eds): New Concepts in Gynecological Oncology . Philadelphia, FA Davis Co, 1968;, p 3.
Rotkin ID:  Sexual characteristics of a cervical cancer population . Amer J Public Health 57:815-829, 1967;.
Nahmias AJ, Josey WE, Naib ZM, et al:  Antibodies to Herpesvirus hominis types 1 and 2 in humans: II. Women with cervical cancer . Amer J Epidem 91:547-552, 1970;.
Royston I, Aurelian L:  Association of genital herpesvirus with cervical atypia and carcinoma in situ . Amer J Epidem 91:531-538, 1970;.
Johnson LD, Nickerson RJ, Easterday CL, et al:  Epidemiologic evidence for the spectrum of change from dysplasia through carcinoma in situ to invasive cancer . Cancer 22:901-914, 1968;.
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