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ARTICLE |

Extreme Hyperthermia After LSD Ingestion FREE

Steven Arthur Friedman, MD; Stuart E. Hirsch, MD
[+] Author Affiliations

Reprint requests to 17 Juniper Rd, Havertown, Pa 19083 (Dr. Friedman).


JAMA. 1971;217(11):1549-1550. doi:10.1001/jama.1971.03190110067020
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Hyperthermia is a known effect of lysergic acid diethylamide (LSD). This is, to our knowledge, the first recorded instance of life-threatening hyperthermia (106.4 F [41.3 C] axillary) in man, following the use of LSD, and may have been dose-related. The hyperthermia was rapidly reversed by alcoholic-ice soaks, hallucinations ended about 18 hours later, and the patient recovered without obvious mental or physical injury.

REFERENCES

Rothlin E:  Lysergic acid diethylamide and related substances . Ann NY Acad Sci 66:668-676, 1957;.
Ferrer GR, Goldner RD:  Experimental physiological studies with lysergic acid diethylamide (LSD-25) . Arch Neurol Psychiat 65:581-588, 1951;.
Horita A, Dille JM:  Pyretogenic effect of lysergic acid diethylamide . Science 120:1100-1101, 1954;.
Feldberg W, Myers RD:  A new concept of temperature regulation by amines in the hypothalamus . Nature 200:1325, 1963;.
Feldberg W, Lotti VJ:  Temperature responses to monoamines and an inhibitor of MAO injected into the cerebral ventricles of rats . Brit J Pharmacol 31:152-161, 1967;.
Myers RD, Veale WL:  Body temperature: Possible ionic mechanisms in the hypothalamus controlling the set point . Science 170:95-97, 1970;.
Giarman NJ, Tanaka C, Mooney J, et al:  Serotonin, norepinephrine, and fever . Advance Pharmacol 6:307-317, 1968;.
van Praag HM:  Indolamines and the central nervous system . Psychiat Neurol Neurochir 73:9-36, 1970;.
Cerletti A, Taeschler N, Weidmann H:  Pharmacologic studies on the structure-activity relationship of hydroxyindole alkylamines . Advances Pharmacol 6:233-246, 1968;.
Horita A, Gogerty JH:  The pyretogenic effect of 5-hydroxytryptophan and its comparison with that of LSD . J Pharmacol Exp Ther 122:195-200, 1958;.
Borison HL, Clark WG:  Drug actions on thermoregulatory mechanisms . Advances Pharmacol 5:129-212, 1967;.
Horita A, Hamilton AE:  Lysergic acid diethylamide: Dissociation of its behavioral and hyperthermic actions by DL-α- methyl-p-tyrosine . Science 164:78-79, 1969;.

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Rothlin E:  Lysergic acid diethylamide and related substances . Ann NY Acad Sci 66:668-676, 1957;.
Ferrer GR, Goldner RD:  Experimental physiological studies with lysergic acid diethylamide (LSD-25) . Arch Neurol Psychiat 65:581-588, 1951;.
Horita A, Dille JM:  Pyretogenic effect of lysergic acid diethylamide . Science 120:1100-1101, 1954;.
Feldberg W, Myers RD:  A new concept of temperature regulation by amines in the hypothalamus . Nature 200:1325, 1963;.
Feldberg W, Lotti VJ:  Temperature responses to monoamines and an inhibitor of MAO injected into the cerebral ventricles of rats . Brit J Pharmacol 31:152-161, 1967;.
Myers RD, Veale WL:  Body temperature: Possible ionic mechanisms in the hypothalamus controlling the set point . Science 170:95-97, 1970;.
Giarman NJ, Tanaka C, Mooney J, et al:  Serotonin, norepinephrine, and fever . Advance Pharmacol 6:307-317, 1968;.
van Praag HM:  Indolamines and the central nervous system . Psychiat Neurol Neurochir 73:9-36, 1970;.
Cerletti A, Taeschler N, Weidmann H:  Pharmacologic studies on the structure-activity relationship of hydroxyindole alkylamines . Advances Pharmacol 6:233-246, 1968;.
Horita A, Gogerty JH:  The pyretogenic effect of 5-hydroxytryptophan and its comparison with that of LSD . J Pharmacol Exp Ther 122:195-200, 1958;.
Borison HL, Clark WG:  Drug actions on thermoregulatory mechanisms . Advances Pharmacol 5:129-212, 1967;.
Horita A, Hamilton AE:  Lysergic acid diethylamide: Dissociation of its behavioral and hyperthermic actions by DL-α- methyl-p-tyrosine . Science 164:78-79, 1969;.
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