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ARTICLE |

Lymphocytotoxic Antibodies In Prostatic Cancer FREE

R. J. Ablin, PhD
JAMA. 1971;216(12):2015-2015. doi:10.1001/jama.1971.03180380069021
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To the Editor.—  The possibility that immunologic factors may influence the growth and development of tumors was considered as early as 1900 by Ehrlich. Stimulated by recent reports suggesting the possible occurrence of immunologic factors in carcinoma of the prostate, we have examined the serum of patients with various stages of clinically and histologically confirmed diagnosed carcinoma of the prostate1-3 for the presence of cytotoxic antibodies (CA) to lymphyocytes from 50 unrelated randomly selected donors by the microcytotoxicity test.4Initially, serum specimens from 22 patients with carcinoma of the prostate admitted for treatment of their malignancy were screened. Upon finding CA in two of these patients, 28 serum specimens from patients with a confirmed diagnosis of benign prostatic hypertrophy, and three patients with carcinoma of the bladder not involving the prostate were tested as controls in a similar manner for the presence of CA. Results of testing these

REFERENCES

Soanes WA, Gonder MJ, Ablin RJ:  A possible immunocryothermic response in prostatic cancer . Clin Radiol 21:253-255, 1970;.
Soanes WA, Ablin RJ, Gonder MJ:  Remission of metastatic lesions following cryosurgery in prostatic cancer: Immunologic considerations . J. Urol 104:154-159, 1970;.
Ablin RJ, Pfeiffer L, Soanes WA, et al:  Precipitating antibody in the sera of patients treated cryosurgically for carcinoma of the prostate . Exp Med Surg 27:406-410, 1969;.
Mittal KK, Mickey MR, Singali DP, et al:  Serotyping for homotransplantation: XXI. A 45 minute microcytotoxicity test . Transplantation 8:801-805, 1969;.

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Soanes WA, Gonder MJ, Ablin RJ:  A possible immunocryothermic response in prostatic cancer . Clin Radiol 21:253-255, 1970;.
Soanes WA, Ablin RJ, Gonder MJ:  Remission of metastatic lesions following cryosurgery in prostatic cancer: Immunologic considerations . J. Urol 104:154-159, 1970;.
Ablin RJ, Pfeiffer L, Soanes WA, et al:  Precipitating antibody in the sera of patients treated cryosurgically for carcinoma of the prostate . Exp Med Surg 27:406-410, 1969;.
Mittal KK, Mickey MR, Singali DP, et al:  Serotyping for homotransplantation: XXI. A 45 minute microcytotoxicity test . Transplantation 8:801-805, 1969;.
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