Adenosine 3',5'-monophosphate (cyclic AMP) is currently of intense interest to scientists in many fields of biology and medicine. Cyclic AMP plays a central role in the mediation of hormonal actions and the regulation of metabolic processes.1 There is considerable experimental evidence for an important role of cyclic AMP in brain function.2 Intracellular cyclic AMP levels may be increased or decreased by a variety of hormones and neurotransmitters, probably through stimulation or inhibition of the activity of adenyl cyclase, the enzyme which synthesizes cyclic AMP.1,2 The mode of action of theophylline and aminophylline in the treatment of heart failure and bronchial asthma has been attributed to the inhibition of phosphodiesterase (the enzyme which catabolizes cyclic AMP), producing increased intracellular cyclic AMP levels in the myocardium and bronchial muscle, which results in more vigorous myocardial contraction and in bronchial dilatation.3
Studies of hormonal and neutrotransmitter excesses, deficiencies, and
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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