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ARTICLE |

Neoplasms After Childhood Irradiation of the Thymus Gland FREE

Murray L. Janower, MD; Olli S. Miettinen, MD, PhD
[+] Author Affiliations

Reprint requests to Massachusetts General Hospital, Boston 02114 (Dr. Janower).


JAMA. 1971;215(5):753-756. doi:10.1001/jama.1971.03180180029006
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The oncogenic effects of childhood irradiation of the thymus gland were investigated by following up 466 irradiated subjects, 506 unirradiated subjects with similar illnesses, and the siblings of both series. In the irradiated group there were two malignant and nine benign thyroid neoplasms, indicating an excess risk in this group. There was also a suggestion of an increased risk of breast cancer. There was no evidence of difference between the hospital and sibling controls; this supports the validity of previous studies using sibling controls.

REFERENCES

Hempelmann LH, Pifer JW, Burke GJ, et al:  Neoplasms in persons treated with x-rays in infancy for thymic enlargement: A report of the third follow-up survey J Nat Cancer Inst 38:317-341, 1967;.
Pifer JW, Hempelmann LH, Dodge JH, et al:  Neoplasms in the Ann Arbor series of thymus irradiated children: A second survey . Amer J Roentgen 103:13-18, 1968;.
Saenger EL, Silverman FN, Sterling TD, et al:  Neoplasia following therapeutic irradiation for benign conditions in childhood . Radiology 74:889-904, 1960;.
Snegireff LS:  Neoplasia in persons who received thymic irradiation in childhood . Acta Un Int Cancr 20:1190-1193, 1964;.
Snegireff LS:  The elusiveness of neoplasia following roentgen therapy for thymic enlargement in childhood . Radiology 72:508-517, 1959;.
Cancer in Connecticut , monograph. Hartford, Conn, Connecticut State Department of Health, 1955;, pp 1935-1951.
Brownlee KA: Statistical Theory and Methodology in Science and Engineering . New York, John Wiley & Sons, 1960;, p 139.
Conti EA, Patton GD, Conti JE, et al:  Present health of childhood given x-ray treatment to anterior mediastinum in infancy . Radiology 74:386-391, 1960;.
Pifer JW, Hempelmann LH:  Radiation induced thyroid carcinoma . Ann NY Acad Sci 114:838-848, 1964;.
Hempelmann LH:  Risk of thyroid neoplasms after irradiation in childhood . Science 160:159-163, 1968;.
Beach SA, Dolphin GW:  A study of the relationship between x-ray dose delivered to the thyroids of children and the subsequent development of malignant tumors . Phys Med Biol 6:583-598, 1962;.

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Hempelmann LH, Pifer JW, Burke GJ, et al:  Neoplasms in persons treated with x-rays in infancy for thymic enlargement: A report of the third follow-up survey J Nat Cancer Inst 38:317-341, 1967;.
Pifer JW, Hempelmann LH, Dodge JH, et al:  Neoplasms in the Ann Arbor series of thymus irradiated children: A second survey . Amer J Roentgen 103:13-18, 1968;.
Saenger EL, Silverman FN, Sterling TD, et al:  Neoplasia following therapeutic irradiation for benign conditions in childhood . Radiology 74:889-904, 1960;.
Snegireff LS:  Neoplasia in persons who received thymic irradiation in childhood . Acta Un Int Cancr 20:1190-1193, 1964;.
Snegireff LS:  The elusiveness of neoplasia following roentgen therapy for thymic enlargement in childhood . Radiology 72:508-517, 1959;.
Cancer in Connecticut , monograph. Hartford, Conn, Connecticut State Department of Health, 1955;, pp 1935-1951.
Brownlee KA: Statistical Theory and Methodology in Science and Engineering . New York, John Wiley & Sons, 1960;, p 139.
Conti EA, Patton GD, Conti JE, et al:  Present health of childhood given x-ray treatment to anterior mediastinum in infancy . Radiology 74:386-391, 1960;.
Pifer JW, Hempelmann LH:  Radiation induced thyroid carcinoma . Ann NY Acad Sci 114:838-848, 1964;.
Hempelmann LH:  Risk of thyroid neoplasms after irradiation in childhood . Science 160:159-163, 1968;.
Beach SA, Dolphin GW:  A study of the relationship between x-ray dose delivered to the thyroids of children and the subsequent development of malignant tumors . Phys Med Biol 6:583-598, 1962;.
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