Long-Term Integrity of Renal Function in Cadaver Allografts FREE

Weldon D. Shelp, MD; Fritz H. Bach, MD; William A. Kisken, MD; Margaret Newton, MD; Richard E. Rieselbach, MD; Arvin B. Weinstein, MD

[+] Author Affiliations

Read in part at the third annual meeting of the American Society of Nephrology, Washington, DC, Dec 2,1969.

Reprint requests to 1300 University Ave, Madison 53706 (Dr. Shelp).

JAMA. 1970;213(9):1443-1447. doi:10.1001/jama.1970.03170350011002

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References

ABSTRACT

ABSTRACT | REFERENCES

In general, renal transplant recipients of cadaver kidneys fare less well than recipients of living related donor kidneys in regard to incidence of rejection episodes and stability of renal function. Specific renal function measurements of four cadaver recipients surviving a mean of 29 months without experiencing rejection are compared with those of seven well-matched living related donor recipients who have maintained optimal stability of renal function a minimum of one year following transplant. Renal function of the cadaver group compared favorably and in certain instances exceeded that of the living donor group. These data indicate that even without histocompatibility testing, transplantation of cadaver kidneys can occasionally result in a sustained preservation of renal function which closely parallels that seen in well-matched recipients. Excluding chance histocompatibility, the factors related to such therapeutic success are unknown.

REFERENCES

ABSTRACT | REFERENCES

Seventh report of the Human Kidney Transplant Registry . Transplantation 8: 721-728, 1969;.

Singal DP, Mickey MR, Terasaki PI: Serotyping for homotransplantation: XXIII. Analysis of kidney transplants from parenteral versus sibling donors . Transplantation 7:246-258, 1969;.

Bach FH, Amos DB: Hu-1, major histocompatibility locus in man . Science 156:1506-1508, 1967;.

Bach FH, Voynow NK: One-way stimulation in mixed leukocyte culture . Science 153:545-547, 1966;.

Roe JH, Epstein JH, Goldstein NP: A photometric method for the determination of inulin in plasma and urine . J Biol Chem 178:839-845, 1949;.

Wrong O, Davies HEF: The excretion of acid in renal disease . Quart J Med 28:259-313, 1959;.

Gyory AZ, Stewart JH, George CRP: Renal tubular acidosis, acidosis due to hyperkalemia, hypercalcemia, disordered citrate metabolism and other tubular dysfunctions following human renal transplantation . Quart J Med 38:231-254, 1969;.

Better OS, Chaimowitz C, Alroy GG: Spontaneous remission of the defect in urinary acidification after cadaver kidney transplantation . Lancet 1:110-112, 1970;.

Shelp, WD, Rieselbach RE: Comparison of concentrating mechanism in the transplanted kidney (TK) vs the remaining donor kidney (DK) , abstracted. Third Annual Meeting of the American Society of Nephrology , Washington, DC, 1969;, p 60.

Hume DM, Lee HM, Williams GM: Comparative results of cadaver and related donor renal homografts in man, and immunologic implications of the outcome of second and paired transplants . Ann Surg 164:352-397, 1966;.

Nakamoto S, Straffon RA, Kolff WJ: Homotransplantation with cadaver kidneys . JAMA 192:302-308, 1965;.

Reeve CE, Martin DC, Gonick HC: Kidney transplantation . Amer J Med 47: 410-420, 1969;.

Moore TC, Hume DM: The period and nature of hazard in clinical renal transplantation . Ann Surg 170:12-24, 1969;.

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