Plasma Renin Activity and Levodopa in Parkinson's Disease FREE

Andrew M. Michelakis, PhD, MD; David Robertson

[+] Author Affiliations

Reprint requests to Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn 37203 (Dr. Michelakis).

JAMA. 1970;213(1):83-85. doi:10.1001/jama.1970.03170270025004

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References

ABSTRACT

ABSTRACT | REFERENCES

The effect of posture and levodopa therapy on plasma renin activity (PRA) was studied in patients with Parkinson's disease. The PRA was measured with the patient supine and upright before and during levodopa administration. Prior to therapy the mean values with the patients supine and upright were significantly lower than those of normal subjects. While they were receiving levodopa, the mean PRA when the patients were supine remained low while the mean value when the patients were upright became normal. There was an exaggerated response of PRA to upright posture with levodopa therapy. Possible relationship of these findings to the underlying mechanisms of Parkinson's disease and its treatment are discussed.

REFERENCES

ABSTRACT | REFERENCES

Kuchel O, Fishman LM, Liddle GW, et al: Effect of diazoxide on plasma renin activity in hypertensive patients . Ann Intern Med 67:791-799, 1967;.

Jose A, Kaplan NM: Plasma renin activity in the diagnosis of primary aldosteronism . Arch Intern Med 123:141-146, 1969;.

Creditor MC, Loschky UK: Incidence of suppressed renin activity and of normokalemic primary aldosteronism in hypertensive negro patients . Circulation 37:1027-1031, 1968;.

Sandstead HH, Michelakis AM, Temple TE: Lead intoxication: Its effect on the renin-aldosterone response to sodium deprivation . Arch Environ Health 20:356-363, 1970;.

Gordon RD, Kuchel O, Liddle GW, et al: Role of the sympathetic nervous system in regulating renin and aldosterone production in man . J Clin Invest 46:599-605, 1967;.

Barbeau A, Gillo-Joffroy L, Boucher R, et al: Renin-aldosterone system in Parkinson's disease . Science 165:291-292, 1969;.

Gordon RD, Wolfe LK, Island DP, et al: A diurnal rhythm in plasma renin activity in man . J Clin Invest 45:1587-1592, 1966;.

Boucher R, Veyrat R, de Champlain J, et al: New procedures for measurement of human plasma angiotensin and renin activity levels . Canad Med Assoc J 90:194-201, 1964;.

Barbeau A, Murphy GF, Sourkes TL: Excretion of dopamine in diseases of basal ganglia . Science 133:1706-1707, 1961;.

Cotzias GC, Van Woert MH, Schiffer LM: Aromatic amino acids and modification of parkinsonism . New Eng J Med 276:374-379, 1965;.

Michelakis AM, Horton R: The relationship between plasma renin and aldosterone in normal man . Circ Res , to be published.

Michelakis AM, Caudle J, Liddle GW: In vitro stimulation of renin production by epinephrine, norepinephrine, and cyclic AMP . Proc Soc Exp Biol Med 130: 748-753, 1969;.

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