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June 1, 1970, Vol 212, No. 9 >
ARTICLE | June 1, 1970

In Vivo Effects of Illicit Hallucinogens on Human Lymphocyte Chromosomes FREE

David Dorrance, MD; Oscar Janiger, MD; Raymond L. Teplitz, MD
[+] Author Affiliations

Reprint requests to 1500 E Duarte Rd, Duarte, Calif 91010 (Dr. Teplitz).


JAMA. 1970;212(9):1488-1491. doi:10.1001/jama.1970.03170220044006
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References

Fourteen subjects exposed to illicit lysergic acid diethylamide (LSD) and nine exposed to marihuana were compared to age-matched controls for effects upon lymphocyte chromosomes. Eight out of 1,284 in the group given LSD, or 0.76%, exhibited chromosomal abnormalities; seven out of 816, or 0.86%, in the group given marihuana; and eight out of 1,018, or 0.79%, in the control group. Cells were grown in medium unenriched with nucleotide precursors. Thus, our negative results mitigate against medium deficiency as contributing toward positive effects. Similarly, our results on individuals whose last dosage was within an hour or so of specimen procurement indicates that this factor may not explain conflicting results.

REFERENCES

1 +
Cohen MM, Marinello MJ, Back N:  Chromosomal damage in human leukocytes induced by lysergic acid diethylamide . Science 155:1417-1419, 1967;.
2 +
Sparkes RS, Melnyk J, Bozzetti LP:  Chromosomal effect in vivo of exposure to lysergic acid diethylamide . Science 160: 1343-1345, 1968;.
3 +
Bender L, Sankar DVS:  Chromosome damage not found in leukocytes of children with LSD-25 . Science 159:749, 1968;.
4 +
Hungerford DA, Taylor KM, Shagass C, et al:  Cytogentic effects of LSD-25 therapy in man . JAMA 206:2287-2291, 1968;.
5 +
Cohen MM, Hirschhorn K, Frosch WA:  In vivo and in vivo chromosomal damage induced by LSD-25 . New Eng J Med 277:1044-1049, 1967;.
6 +
Alexander GJ, et al:  LSD: Injection early in pregnancy produces abnormalities in offspring of rats . Science 157:459-460, 1967;.
7 +
Warkany J, Tolacs E:  Lysergic acid diethylamine (LSD): No teratogenicity in rats . Science 159:731-732, 1968;.
8 +
Geber WF:  Congenital malformations induced by mescaline, lysergic acid diethylamine, and bromolysergic acid in the hamster . Science 158:265-267, 1967;.
9 +
Cohen MM, Mukherjee AB:  Meiotic chromosome damage induced by LSD-25 . Nature 219:1072-1074, 1968;.
10 +
Skakkebaek NE, Rafaelsen OJ:  LSD in mice: Abnormalities in meiotic chromosomes Science 160:1246-1248, 1968;.
11 +
Egozcue J, Irwin S, Maruffo CA:  Chromosomal damage in LSD users . JAMA 204:214-218, 1968;.
12 +
Loughman WD, Sargent TW, Israelstam DM:  Leukocytes of humans exposed to lysergic acid diethylamide: Lack of chromosome damage . Science 158:508-510, 1967;.
13 +
Cohen MM, et al:  The effect of LSD25 on the chromosomes of children exposed in-utero . Pediat Res 2:486-492, 1968;.
14 +
Zellweger H, McDonald JS, Abbo G:  Is lysergic acid diethylamide a teratogen? Lancet 2:1066-1068, 1967;.
15 +
Teplitz RL:  Cytogenetics, in Amromin GD  (ed): Pathology of Leukemia . New York, Harper & Row Publishers, 1968;, chap 5.
16 +
Moorhead PS, et al:  Chromosome preparations of leukocytes cultured from human peripheral blood . Exp Cell Res 20: 613-616, 1960;.
17 +
German J, Grippa LP:  Chromosomal breakage in diploid cell lines from Bloom's syndrome and Fanconi's anemia . Ann Ge net 9:143-154, 1966;.
18 +
Grossbard L, Rosen D, McGilvray E, et al:  Acute leukemia with Ph1-like chromosome in an LSD user . JAMA 205:791-793, 1968;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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1 +
Cohen MM, Marinello MJ, Back N:  Chromosomal damage in human leukocytes induced by lysergic acid diethylamide . Science 155:1417-1419, 1967;.
2 +
Sparkes RS, Melnyk J, Bozzetti LP:  Chromosomal effect in vivo of exposure to lysergic acid diethylamide . Science 160: 1343-1345, 1968;.
3 +
Bender L, Sankar DVS:  Chromosome damage not found in leukocytes of children with LSD-25 . Science 159:749, 1968;.
4 +
Hungerford DA, Taylor KM, Shagass C, et al:  Cytogentic effects of LSD-25 therapy in man . JAMA 206:2287-2291, 1968;.
5 +
Cohen MM, Hirschhorn K, Frosch WA:  In vivo and in vivo chromosomal damage induced by LSD-25 . New Eng J Med 277:1044-1049, 1967;.
6 +
Alexander GJ, et al:  LSD: Injection early in pregnancy produces abnormalities in offspring of rats . Science 157:459-460, 1967;.
7 +
Warkany J, Tolacs E:  Lysergic acid diethylamine (LSD): No teratogenicity in rats . Science 159:731-732, 1968;.
8 +
Geber WF:  Congenital malformations induced by mescaline, lysergic acid diethylamine, and bromolysergic acid in the hamster . Science 158:265-267, 1967;.
9 +
Cohen MM, Mukherjee AB:  Meiotic chromosome damage induced by LSD-25 . Nature 219:1072-1074, 1968;.
10 +
Skakkebaek NE, Rafaelsen OJ:  LSD in mice: Abnormalities in meiotic chromosomes Science 160:1246-1248, 1968;.
11 +
Egozcue J, Irwin S, Maruffo CA:  Chromosomal damage in LSD users . JAMA 204:214-218, 1968;.
12 +
Loughman WD, Sargent TW, Israelstam DM:  Leukocytes of humans exposed to lysergic acid diethylamide: Lack of chromosome damage . Science 158:508-510, 1967;.
13 +
Cohen MM, et al:  The effect of LSD25 on the chromosomes of children exposed in-utero . Pediat Res 2:486-492, 1968;.
14 +
Zellweger H, McDonald JS, Abbo G:  Is lysergic acid diethylamide a teratogen? Lancet 2:1066-1068, 1967;.
15 +
Teplitz RL:  Cytogenetics, in Amromin GD  (ed): Pathology of Leukemia . New York, Harper & Row Publishers, 1968;, chap 5.
16 +
Moorhead PS, et al:  Chromosome preparations of leukocytes cultured from human peripheral blood . Exp Cell Res 20: 613-616, 1960;.
17 +
German J, Grippa LP:  Chromosomal breakage in diploid cell lines from Bloom's syndrome and Fanconi's anemia . Ann Ge net 9:143-154, 1966;.
18 +
Grossbard L, Rosen D, McGilvray E, et al:  Acute leukemia with Ph1-like chromosome in an LSD user . JAMA 205:791-793, 1968;.

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