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Report to the Secretary of HEW From the Medical Advisory Group on Cyclamates FREE

Roger O. Egeberg, MD; Jesse L. Steinfeld, MD; Ivan Frantz, MD; George C. Griffith, MD; Harvey Knowles, Jr., MD; Edward Rosenow, MD; Henry Sebrell, MD; Theodore Van Itallie, MD
[+] Author Affiliations

Reprint requests to Surgeon General of the Public Health Service, Department of Health, Education, and Welfare, Washington, DC 20201 (Dr. Steinfeld).


JAMA. 1970;211(8):1358-1361. doi:10.1001/jama.1970.03170080046010
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The Medical Advisory Group on Cyclamates appointed by Secretary Finch met on Nov 17 and 18, 1969, with representatives of the Food and Drug Administration and the National Institutes of Health to review the currently available data on the possible harmful effects of these nonnutritive sweeteners in relation to their potential benefits. The group considered the data on carcinogenic, mutagenic, teratogenic, enzymatic, osmotic, and growth effects of cyclamates and on their possible adverse influence in interaction with other drugs.

After carefully reviewing the evidence currently available, the Medical Advisory Group on Cyclamates unanimously supported the secretary's prohibition of the inclusion of cyclamates in beverages for general use, and in the future processing of general purpose foods and vegetables. It recognized, however, that in the medical management of individuals with diabetes (and particularly in the case of juvenile diabetes) or patients in whom weight reduction and control are essential for health,

REFERENCES

National Academy of Sciences-National Research Council; The Safety of Artificial Sweeteners for Use in Foods, publication 384, 1955.
Specifications for the Identity and Purity of Food Additives and Their Toxicological Evaluation; Some Flavoring Substances and Non-nutritive Sweetening Agents , 11th report, publication 44. Rome, Food and Agriculture Organization and World Health Organization Expert Committee on Food Additives, 1968;.
Boros E:  An experience with artificial sweeteners . JAMA 194:571-572, 1965;.
Kobori, R, Araki H:  Photoallergy . J Asthma Res 3:213-215, 1966;.
Lamberg SI:  A new photosensitizer: The artificial sweetener cyclamate . JAMA 201:747-750, 1967;.
Coulston FV, Golberg L: FDA Progress Report on Contract 69-7 . Albany Medical College, Union University, Institute of Experimental Pathology and Toxicology, 1969;.
Lomonova GV:  Toxicity of cyclohexylamine and dicyclohexylamine . Gig Tr Prof Zabol 7:95-98, 1961;.
Stone D, Lamson E, Chang YS, et al:  Cytogenetic effects of cyclamates on human cells in vitro . Science 164:568-569, 1969;.
Legator MS, Palmer KA, Green S, et al:  Cytogenetic studies in rats of cyclohexylamine, a metabolite of cyclamate . Science 165:1139-1140, 1969;.
Verret MJ: Teratogenic Effects of Cyclamate and Related Compounds in the Chicken Embryo: Report on Non-nutritive Sweeteners . Bureau of Science-Bureau of Medicine, Food and Drug Administration, 111-24, 1969;.
Lockwood RR; Dixon, RL:  The effect of cyclamate on the hypoglycemic response of tolbutamide and chlorpropamide in rats . Food Cosmet Toxic 7:1-7, 1969;.
Holcenberg JS; Bidgood M; Dixon, RL:  Possible interaction between cyclamate and warfarin . Curr Ther Res 11:577-584, 1969;.
Wagner JJ:  The bitter sweeteners . Sciences 9:20-25, 1969;.

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National Academy of Sciences-National Research Council; The Safety of Artificial Sweeteners for Use in Foods, publication 384, 1955.
Specifications for the Identity and Purity of Food Additives and Their Toxicological Evaluation; Some Flavoring Substances and Non-nutritive Sweetening Agents , 11th report, publication 44. Rome, Food and Agriculture Organization and World Health Organization Expert Committee on Food Additives, 1968;.
Boros E:  An experience with artificial sweeteners . JAMA 194:571-572, 1965;.
Kobori, R, Araki H:  Photoallergy . J Asthma Res 3:213-215, 1966;.
Lamberg SI:  A new photosensitizer: The artificial sweetener cyclamate . JAMA 201:747-750, 1967;.
Coulston FV, Golberg L: FDA Progress Report on Contract 69-7 . Albany Medical College, Union University, Institute of Experimental Pathology and Toxicology, 1969;.
Lomonova GV:  Toxicity of cyclohexylamine and dicyclohexylamine . Gig Tr Prof Zabol 7:95-98, 1961;.
Stone D, Lamson E, Chang YS, et al:  Cytogenetic effects of cyclamates on human cells in vitro . Science 164:568-569, 1969;.
Legator MS, Palmer KA, Green S, et al:  Cytogenetic studies in rats of cyclohexylamine, a metabolite of cyclamate . Science 165:1139-1140, 1969;.
Verret MJ: Teratogenic Effects of Cyclamate and Related Compounds in the Chicken Embryo: Report on Non-nutritive Sweeteners . Bureau of Science-Bureau of Medicine, Food and Drug Administration, 111-24, 1969;.
Lockwood RR; Dixon, RL:  The effect of cyclamate on the hypoglycemic response of tolbutamide and chlorpropamide in rats . Food Cosmet Toxic 7:1-7, 1969;.
Holcenberg JS; Bidgood M; Dixon, RL:  Possible interaction between cyclamate and warfarin . Curr Ther Res 11:577-584, 1969;.
Wagner JJ:  The bitter sweeteners . Sciences 9:20-25, 1969;.
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