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Posttransfusion Hepatitis After Open-Heart Operations: Title and subTitle BreakIncidence After the Administration of Blood From Commercial and Volunteer Donor Populations FREE

John H. Walsh, MD; Robert H. Purcell, MD; Andrew G. Morrow, MD; Robert M. Chanock, MD; Paul J. Schmidt, MD
[+] Author Affiliations

Read in part before the American Association of Blood Banks, Washington, DC, Oct 30, 1968.

Reprint requests to Bldg 10A, Room 1E-33, 9000 Rockville Pike, National Institutes of Health, Bethesda, Md 20014 (Dr. Schmidt).


JAMA. 1970;211(2):261-265. doi:10.1001/jama.1970.03170020025005
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The incidence of icteric and anicteric hepatitis was determined prospectively in 110 patients undergoing open-heart operations in which cardiopulmonary bypass was used. Patients were supplied with blood from two commercial blood banks (82 patients), or from local volunteer donors (28 patients). Serial determinations of serum transaminase levels were obtained for six months following operation. Hepatitis developed in 51% (42) of the recipients of commercial blood, but the disease did not occur in any patient who received blood from volunteer donors. The hepatitis carrier rate for commercial blood donors was 6.3%, but, for volunteer donors, was less than 0.6%. This difference in carrier rates probably reflects differences in the donor populations.

REFERENCES

Allen, J.G., et al:  Blood Transfusions and Serum Hepatitis: Use of Monochloroacetate As an Antibacterial Agent in Plasma , Ann Surg 150:455-467, 1959;.
Cohen, S.N., and Dougherty, W.J.:  Transfusion Hepatitis Arising From Addict Blood Donors , JAMA 203:427-429 ( (Feb 5) ) 1968;.
Kunin, C.M.:  Serum Hepatitis From Whole Blood: Incidence and Relation to Source of Blood , Amer J Med Sci 237:293-303, 1959;.
Grady, G.F., and Chalmers, T.C.:  Risk of Post-transfusion Viral Hepatitis , New Eng J Med 271:337-342 ( (Aug 13) ) 1964;.
Rubinson, R.M., et al:  Serum Hepatitis After Open-Heart Operations , J Thorac Cardiovasc Surg 50:575-581, 1965;.
Holland, P.V., et al:  γ-Globulin in the Prophylaxis of Posttransfusion Hepatitis , JAMA 196:471-474 ( (May 9) ) 1966;.
Senior, J.R.:  Reflections Upon the Incidence of Posttransfusion Hepatitis in Various Parts of the World , Amer J Gastroent 49:298-303, 1968;.
Kossmann, C.E.: Diseases of the Heart and Blood Vessels: Nomenclature and Criteria for Diagnosis , ed 2, Boston: Little, Brown & Co., 1964;, pp 112-113.
Creutzfeldt, W., et al:  Untersuchungen zur Prophylaxe der Transfusions hepatitis durch Gamma-Globulin , Deutsch Med Wschr 43:1905-1908 ( (Oct 28) ) 1966;.
Shimizeu, U., and Kitamoto, D.:  The Incidence of Viral Hepatitis After Blood Transfusions , Gastroenterology 44:740-744, 1963;.
Hampers, C.L.; Prager, D.; and Senior, J.R.:  Post-transfusion Anicteric Hepatitis , New Eng J Med 271:747-754, 1964;.
Mirick, G.S.; Ward, R.; and McCollum, R.W.:  Modification of Post-transfusion Hepatitis by Gamma-Globulin New Eng J Med 273:59-65, 1965;.
Clermont, R.J., and Chalmers, T.C.:  The Transaminase Tests in Liver Disease , Medicine 46:197-207, 1967;.
Redeker, A.G., et al:  A Controlled Study of the Safety of Pooled Plasma Stored in the Liquid State at 30-32 C for Six Months , Transfusion 8:57-64, 1968;.
Hepatitis Surveillance Reports , Atlanta: National Communicable Disease Center, September 1967, vol 27; (September) 1969;, vol 29.
Maxwell, N.G.:  Incidence of Serum Hepatitis in Recipients of Thymol-Turbidity-Screened Blood or Aged Liquid Plasma , Amer J Clin Path 34:518-525, 1960;.
Norris, R.F.; Potter, H.P.; and Reinhold, J.G.:  Present Status of Hepatic Function Tests in the Detection of Carriers of Viral Hepatitis , Transfusion 3:202-210, 1963;.
Bevan, G.; Taswell, H.F.; and Gleich, G.J.:  Serum Immunoglobulin Levels in Blood Donors Implicated in Transmission of Hepatitis , JAMA 203:92-94 ( (Jan 1) ) 1968;.
Levine, C., and Blumberg, B.S.:  Additional Specificities of Austrailia Antigen and the Possible Identification of Hepatitis Carriers , Nature 221:195-196, 1969;.
Purcell, R.H., et al:  A Complement-Fixation Test for Measuring Australia Antigen and Antibody , J Infect Dis 120:383-386, 1969;.

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Allen, J.G., et al:  Blood Transfusions and Serum Hepatitis: Use of Monochloroacetate As an Antibacterial Agent in Plasma , Ann Surg 150:455-467, 1959;.
Cohen, S.N., and Dougherty, W.J.:  Transfusion Hepatitis Arising From Addict Blood Donors , JAMA 203:427-429 ( (Feb 5) ) 1968;.
Kunin, C.M.:  Serum Hepatitis From Whole Blood: Incidence and Relation to Source of Blood , Amer J Med Sci 237:293-303, 1959;.
Grady, G.F., and Chalmers, T.C.:  Risk of Post-transfusion Viral Hepatitis , New Eng J Med 271:337-342 ( (Aug 13) ) 1964;.
Rubinson, R.M., et al:  Serum Hepatitis After Open-Heart Operations , J Thorac Cardiovasc Surg 50:575-581, 1965;.
Holland, P.V., et al:  γ-Globulin in the Prophylaxis of Posttransfusion Hepatitis , JAMA 196:471-474 ( (May 9) ) 1966;.
Senior, J.R.:  Reflections Upon the Incidence of Posttransfusion Hepatitis in Various Parts of the World , Amer J Gastroent 49:298-303, 1968;.
Kossmann, C.E.: Diseases of the Heart and Blood Vessels: Nomenclature and Criteria for Diagnosis , ed 2, Boston: Little, Brown & Co., 1964;, pp 112-113.
Creutzfeldt, W., et al:  Untersuchungen zur Prophylaxe der Transfusions hepatitis durch Gamma-Globulin , Deutsch Med Wschr 43:1905-1908 ( (Oct 28) ) 1966;.
Shimizeu, U., and Kitamoto, D.:  The Incidence of Viral Hepatitis After Blood Transfusions , Gastroenterology 44:740-744, 1963;.
Hampers, C.L.; Prager, D.; and Senior, J.R.:  Post-transfusion Anicteric Hepatitis , New Eng J Med 271:747-754, 1964;.
Mirick, G.S.; Ward, R.; and McCollum, R.W.:  Modification of Post-transfusion Hepatitis by Gamma-Globulin New Eng J Med 273:59-65, 1965;.
Clermont, R.J., and Chalmers, T.C.:  The Transaminase Tests in Liver Disease , Medicine 46:197-207, 1967;.
Redeker, A.G., et al:  A Controlled Study of the Safety of Pooled Plasma Stored in the Liquid State at 30-32 C for Six Months , Transfusion 8:57-64, 1968;.
Hepatitis Surveillance Reports , Atlanta: National Communicable Disease Center, September 1967, vol 27; (September) 1969;, vol 29.
Maxwell, N.G.:  Incidence of Serum Hepatitis in Recipients of Thymol-Turbidity-Screened Blood or Aged Liquid Plasma , Amer J Clin Path 34:518-525, 1960;.
Norris, R.F.; Potter, H.P.; and Reinhold, J.G.:  Present Status of Hepatic Function Tests in the Detection of Carriers of Viral Hepatitis , Transfusion 3:202-210, 1963;.
Bevan, G.; Taswell, H.F.; and Gleich, G.J.:  Serum Immunoglobulin Levels in Blood Donors Implicated in Transmission of Hepatitis , JAMA 203:92-94 ( (Jan 1) ) 1968;.
Levine, C., and Blumberg, B.S.:  Additional Specificities of Austrailia Antigen and the Possible Identification of Hepatitis Carriers , Nature 221:195-196, 1969;.
Purcell, R.H., et al:  A Complement-Fixation Test for Measuring Australia Antigen and Antibody , J Infect Dis 120:383-386, 1969;.
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