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ARTICLE |

Herpesviruses and Cancer FREE

Clyde R. Goodheart, MD
[+] Author Affiliations

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JAMA. 1970;211(1):91-96. doi:10.1001/jama.1970.03170010045008
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The herpesviruses form a large group with many common properties. Many animal species have one or more distinct herpesviruses. Strong evidence is available that at least two nonhuman herpesviruses are able to induce malignancy in nonhuman vertebrates, and weak but suggestive evidence exists for four others. There is also suggestive evidence for an association of two herpesviruses with human malignancies. Because proper experiments cannot be done with oncogenic viruses in humans, studies with oncogenic herpesviruses of other animals are extremely important to understanding human cancer.

REFERENCES

Plummer, G., et al:  A Comparative Study of the DNA Density and Behavior in Tissue Cultures of 14 Different Herpesvirus , Virology 39:134-137 ( (Sept) ) 1969;.
Goodheart, C.R.; Plummer, G.; and Waner, J.L.:  Density Difference of DNA of Human Herpes Simplex Virsus, Types 1 and 2 , Virology 35:473-475 ( (July) ) 1968;.
Opler, S.R.:  Animal Model of Viral Oncogenesis , Nature 215: 184 ( (July 8) ) 1967;.
Hsiung, G.D., and Kaplow, L.S.:  Herpeslike Virus Isolated From Spontaneously Degenerated Tissue Culture Derived From Leukemia-Susceptible Guinea Pigs , J Virol 3:355-357 ( (March) ) 1969;.
Meléndez, L.V., et al:  Herpesvirus: II. Experimentally Induced Malignant Lymphoma in Primates , Lab Anim Care 19: 378-386 ( (June) ) 1969;.
Bell, T.M.:  Viruses Associated With Burkitt's Tumor , Progr Med Virol 9:1-34, 1967;.
Epstein, M.A., and Achong, B.G.:  Specific Immunofluorescence Test for the Herpes-Type EB Virus of Burkitt Lymphoblasts, Authenticated by Electron Microscopy , J Nat Cancer Inst 40:593-607 ( (March) ) 1968;.
Henle, G., and Henle, W.:  Immunofluorescence in Cells Derived From Burkitt's Lymphoma , J Bact 91:1248-1256 ( (March) ) 1966;.
Goodheart, C.R.:  Investigation of the Density of DNA From Herpeslike (EB) Virus: A Preliminary Report , Bact Proc , (May) 1969;, p. 153.
Stewart, S.E., et al:  Studies on the Hamster-Brain Passage Virus Recovered From Human Lymphoma Cultures , J Nat Cancer Inst 40:423-428 ( (Feb) ) 1968;.
Henle, G.; Henle, W.; and Diehl, V.:  Relation of Burkitt's Tumor-Associated Herpes-Type Virus to Infectious Mononucleosis , Proc Nat Acad Sci USA 59:94-101 ( (Jan) ) 1968;.
Porter, D.D.; Wimberley, I.; and Benyesh-Melnick, M.:  Prevalence of Antibodies to EB Virus and Other Herpesviruses , JAMA 208:1675-1679 ( (June 2) ) 1969;.
Rawls, W.E., et al:  Herpesvirus Type 2: Association With Carcinoma of the Cervix , Science 161:1255-1256 ( (Sept 20) ) 1968;.
Nahmias, A.J.; Naib, Z.M.; and Josey, W.E.:  Association of Genital Herpesvirus With Cervical Cancer , Int Virol 1:187-188, 1969;.

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Plummer, G., et al:  A Comparative Study of the DNA Density and Behavior in Tissue Cultures of 14 Different Herpesvirus , Virology 39:134-137 ( (Sept) ) 1969;.
Goodheart, C.R.; Plummer, G.; and Waner, J.L.:  Density Difference of DNA of Human Herpes Simplex Virsus, Types 1 and 2 , Virology 35:473-475 ( (July) ) 1968;.
Opler, S.R.:  Animal Model of Viral Oncogenesis , Nature 215: 184 ( (July 8) ) 1967;.
Hsiung, G.D., and Kaplow, L.S.:  Herpeslike Virus Isolated From Spontaneously Degenerated Tissue Culture Derived From Leukemia-Susceptible Guinea Pigs , J Virol 3:355-357 ( (March) ) 1969;.
Meléndez, L.V., et al:  Herpesvirus: II. Experimentally Induced Malignant Lymphoma in Primates , Lab Anim Care 19: 378-386 ( (June) ) 1969;.
Bell, T.M.:  Viruses Associated With Burkitt's Tumor , Progr Med Virol 9:1-34, 1967;.
Epstein, M.A., and Achong, B.G.:  Specific Immunofluorescence Test for the Herpes-Type EB Virus of Burkitt Lymphoblasts, Authenticated by Electron Microscopy , J Nat Cancer Inst 40:593-607 ( (March) ) 1968;.
Henle, G., and Henle, W.:  Immunofluorescence in Cells Derived From Burkitt's Lymphoma , J Bact 91:1248-1256 ( (March) ) 1966;.
Goodheart, C.R.:  Investigation of the Density of DNA From Herpeslike (EB) Virus: A Preliminary Report , Bact Proc , (May) 1969;, p. 153.
Stewart, S.E., et al:  Studies on the Hamster-Brain Passage Virus Recovered From Human Lymphoma Cultures , J Nat Cancer Inst 40:423-428 ( (Feb) ) 1968;.
Henle, G.; Henle, W.; and Diehl, V.:  Relation of Burkitt's Tumor-Associated Herpes-Type Virus to Infectious Mononucleosis , Proc Nat Acad Sci USA 59:94-101 ( (Jan) ) 1968;.
Porter, D.D.; Wimberley, I.; and Benyesh-Melnick, M.:  Prevalence of Antibodies to EB Virus and Other Herpesviruses , JAMA 208:1675-1679 ( (June 2) ) 1969;.
Rawls, W.E., et al:  Herpesvirus Type 2: Association With Carcinoma of the Cervix , Science 161:1255-1256 ( (Sept 20) ) 1968;.
Nahmias, A.J.; Naib, Z.M.; and Josey, W.E.:  Association of Genital Herpesvirus With Cervical Cancer , Int Virol 1:187-188, 1969;.
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