When in 1927 and again in 19351 Sheldon suggested that idiopathic hemochromatosis was attributable to an inborn error of iron metabolism, he based the concept on a small number of cases in which there appeared to be a familial occurrence of this disease. And although the incidence of overt familial involvement subsequently reported by other observers remained small, the genetic etiology found support in the elevated values of serum iron detected in immediate relatives of sufferers from this disease. Liver biopsies studies by Williams and associates2 in families of 16 patients provided additional evidence. In 28 of the 46 relatives examined, biopsy sections gave a positive reaction for free iron, and in a further six cases electron microscopy demonstrated excess of iron.
The genetic etiology of idiopathic hemochromatosis was questioned by MacDonald and Mallory,3 who expressed the view that this disease is not a distinct entity but
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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