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Pseudogynecomastia Due to Penicillin Adjuvant FREE

Robert M. Schmidt, MD; Jack W.C. Hagstrom, MD
JAMA. 1969;209(7):1088-1088. doi:10.1001/jama.1969.03160200052025
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To the Editor:—  Bilateral breast enlargement in the male occurs in association with a variety of conditions, eg, cirrhosis, metabolic disorders of the testes and adrenals, and tumors of these and other organs. It must be distinguished from the uncommon carcinoma of the male breast. This case of bilateral, symmetrical pseudogynecomastia presents a rare cause of mammary enlargement in males, and an example of an unusual, untoward complication of therapy.

Report of a Case:—  This 42-year-old white man was admitted with a chief complaint of breast enlargement bilaterally of six years' duration. While on assignment with the armed forces in Chile in 1961, the patient thought he had contracted venereal disease and, accordingly, consulted a local physician to avoid reprimand by his superiors. On three successive days he received bilateral subareolar injections of a medication which an interpreter told him was penicillin. The patient was unable to explain why the

REFERENCES

Mook, W.H., and Wander, W.G.:  Camphor Oil Tumors , Arch Derm Syph 1:304-318 ( (March) ) 1920;.
Romansky. M.J., and Rittman, G.E.:  A Method of Prolonging the Action of Penicillin , Science 100:196-198 ( (Sept 1) ) 1944;.
Katsuhiko, I.:  Penicillin Oil Preparation , Chem Abst 50:8976 ( (June 25) ) 1956;.
Shibayama, T.:  Oily Suspension of Penicillin , Chem Abst 54:14101 ( (Aug 25) ) 1958;.
Brown, W.E.: Wilder, V.M.; and Schwartz, P.:  A Study of Oils Used for Intramuscular Injections , J Lab Clin Med 29:259-264 ( (March) ) 1944;.
Story, P.:  Histological Reactions to Procaine Penicillin in Oil , Brit Med J 1:1467-1468 ( (June 24) ) 1950;.
Peck, H.M.; et al:  New Metabolizable Immunologic Adjuvant for Human Use, II. Short-Term Animal Toxicity Tests , Proc Soc Exp Biol Med 116:523-530 ( (June) ) 1964;.

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Mook, W.H., and Wander, W.G.:  Camphor Oil Tumors , Arch Derm Syph 1:304-318 ( (March) ) 1920;.
Romansky. M.J., and Rittman, G.E.:  A Method of Prolonging the Action of Penicillin , Science 100:196-198 ( (Sept 1) ) 1944;.
Katsuhiko, I.:  Penicillin Oil Preparation , Chem Abst 50:8976 ( (June 25) ) 1956;.
Shibayama, T.:  Oily Suspension of Penicillin , Chem Abst 54:14101 ( (Aug 25) ) 1958;.
Brown, W.E.: Wilder, V.M.; and Schwartz, P.:  A Study of Oils Used for Intramuscular Injections , J Lab Clin Med 29:259-264 ( (March) ) 1944;.
Story, P.:  Histological Reactions to Procaine Penicillin in Oil , Brit Med J 1:1467-1468 ( (June 24) ) 1950;.
Peck, H.M.; et al:  New Metabolizable Immunologic Adjuvant for Human Use, II. Short-Term Animal Toxicity Tests , Proc Soc Exp Biol Med 116:523-530 ( (June) ) 1964;.
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