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Intestinal Response to the Body's Requirement for Iron: Title and subTitle BreakControl of Iron Absorption FREE

William H. Crosby, MD
[+] Author Affiliations

Reprint requests to Department of Foods and Nutrition, American Medical Association, 535 N Dearborn St, Chicago 60610.

The Council has authorized publication of this report. Philip L. White, ScD, Secretary


JAMA. 1969;208(2):347-351. doi:10.1001/jama.1969.03160020115016
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Dietary iron is absorbed by the mucosa of the small intestine in response to the body's requirement for iron. To a great extent, the amount of iron in the body is maintained at a constant level, not by excretion of excess iron but by the ability of the intestine to reject available, unneeded dietary iron.1 Excretion of iron is limited and, under normal conditions, apparently serves as a fine adjustment to the more important control provided by the intestinal mucosal block.1 When the requirement for iron increases as it does in iron deficiency states, the mucosal block is relaxed to permit the entry of more than the usual amount of dietary iron. When the iron deficiency has been satisfied, the mucosal block is restored to prevent the accumulation by the body of excessive amounts of storage iron. Ordinarily, the intestine absorbs only enough iron to replace the obligatory metabolic

REFERENCES

Crosby, W.H.:  Control of Iron Balance by Intestinal Mucosa , Blood 22:441 ( (Oct) ) 1963;.
Conrad, M.E., and Crosby, W.H.:  Intestinal Mucosal Mechanism's Controlling Iron Absorption , Blood 22:406-415 ( (Oct) ) 1963;.
Conrad, M.E.; Weintraub, L.R.; and Crosby, W.H.:  Role of the Intestine in Iron Kinetics , J Clin Invest 43:963-974 ( (May) ) 1964;.
Bessis, M.C., and Breton-Gorius, J.:  Iron Metabolism in the Bone Marrow as Seen by Electron Microscopy: A Critical Review , Blood 19:635-663 ( (June) ) 1962;.
Akeson, A., et al:  Life Span of Myoglobin , Arch Biochem 91:310-318, 1960;.
Crosby, W.H.; Conrad, M.E.; and Wheby, M.S.:  Rate of Iron Accumulation in Iron Storage Disease , Blood 22:429-440 ( (Aug) ) 1963;.
Thirayothin, P., and Crosby, W.H.:  A Possibility That the Small Intestine May be an Excretory Organ for Debris , Am J Dig Dis 7:975 ( (Nov) ) 1962;.
Weintraub, L.R.; Conrad, M.E.; and Crosby, W.H.:  The Significance of Iron Turnover in the Control of Iron Absorption , Blood 24:10-24 ( (July) ) 1964;.
Pollack, S.; Kaufman, R.M.; and Crosby, W.H.:  Iron Absorption: Effect of an Iron-Deficient Diet , Science 144:1015-1016 ( (May 22) ) 1964;.
Weintraub, L.R.; Conrad, M.E.; and Crosby, W.H.:  Role of Hepatic Iron Stores in the Control of Iron Absorption , J Clin Invest 43:40-44 ( (Jan) ) 1964;.
Crosby, W.H.:  The Control of Iron Absorption , Series Haemat 6:66-71, 1965;.
Bothwell, T.H., and Finch, C.A.: Iron Metabolism , Boston: Little, Brown & Co., 1962;.
Crosby, W.H., and Conrad, M.E.:  Iron Balance in Thalassemia Minor: A Preliminary Report , Ann NY Acad Sci 119:616-623 ( (Oct 7) ) 1964;.
Weintraub, L.R.; Conrad, M.E.; and Crosby, W.H.:  Regulation of the Intestinal Absorption of Iron by the Rate of Erythropoiesis , Brit J Haemat 11:432-438 ( (July) ) 1965;.
Mendel, G.A.: " Erythropoiesis and Iron Absorption ," in Jacobson, L.O., and Doyle, M. (eds.): Erythropoiesis , New York: Grune & Stratton, Inc., 1962;, p 247.

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Crosby, W.H.:  Control of Iron Balance by Intestinal Mucosa , Blood 22:441 ( (Oct) ) 1963;.
Conrad, M.E., and Crosby, W.H.:  Intestinal Mucosal Mechanism's Controlling Iron Absorption , Blood 22:406-415 ( (Oct) ) 1963;.
Conrad, M.E.; Weintraub, L.R.; and Crosby, W.H.:  Role of the Intestine in Iron Kinetics , J Clin Invest 43:963-974 ( (May) ) 1964;.
Bessis, M.C., and Breton-Gorius, J.:  Iron Metabolism in the Bone Marrow as Seen by Electron Microscopy: A Critical Review , Blood 19:635-663 ( (June) ) 1962;.
Akeson, A., et al:  Life Span of Myoglobin , Arch Biochem 91:310-318, 1960;.
Crosby, W.H.; Conrad, M.E.; and Wheby, M.S.:  Rate of Iron Accumulation in Iron Storage Disease , Blood 22:429-440 ( (Aug) ) 1963;.
Thirayothin, P., and Crosby, W.H.:  A Possibility That the Small Intestine May be an Excretory Organ for Debris , Am J Dig Dis 7:975 ( (Nov) ) 1962;.
Weintraub, L.R.; Conrad, M.E.; and Crosby, W.H.:  The Significance of Iron Turnover in the Control of Iron Absorption , Blood 24:10-24 ( (July) ) 1964;.
Pollack, S.; Kaufman, R.M.; and Crosby, W.H.:  Iron Absorption: Effect of an Iron-Deficient Diet , Science 144:1015-1016 ( (May 22) ) 1964;.
Weintraub, L.R.; Conrad, M.E.; and Crosby, W.H.:  Role of Hepatic Iron Stores in the Control of Iron Absorption , J Clin Invest 43:40-44 ( (Jan) ) 1964;.
Crosby, W.H.:  The Control of Iron Absorption , Series Haemat 6:66-71, 1965;.
Bothwell, T.H., and Finch, C.A.: Iron Metabolism , Boston: Little, Brown & Co., 1962;.
Crosby, W.H., and Conrad, M.E.:  Iron Balance in Thalassemia Minor: A Preliminary Report , Ann NY Acad Sci 119:616-623 ( (Oct 7) ) 1964;.
Weintraub, L.R.; Conrad, M.E.; and Crosby, W.H.:  Regulation of the Intestinal Absorption of Iron by the Rate of Erythropoiesis , Brit J Haemat 11:432-438 ( (July) ) 1965;.
Mendel, G.A.: " Erythropoiesis and Iron Absorption ," in Jacobson, L.O., and Doyle, M. (eds.): Erythropoiesis , New York: Grune & Stratton, Inc., 1962;, p 247.
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