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ARTICLE |

Gastrointestinal Protein Allergy: Title and subTitle BreakImmunologic Considerations FREE

Thomas W. Self, MD; Teodoro Herskovic, MD; Emily Czapek, MD; Daniel Caplan, MD; Trudy Schonberger; Joyce D. Gryboski, MD
[+] Author Affiliations

Reprint requests to 333 Cedar St, New Haven, Conn 06510 (Dr. Gryboski).


JAMA. 1969;207(13):2393-2396. doi:10.1001/jama.1969.03150260053005
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Stool specimens were examined for precipitating antibodies to milk, soy, and cereal products from 25 children with chronic diarrhea without determined organic cause. Specimens were also obtained from 30 age-matched controls who had no gastrointestinal, respiratory, or allergic symptoms. Results of roentgenographic gastrointestinal examination and absorption studies revealed no abnormalities in 90% of the patients. Malabsorption pattern was present roentgenologically in three patients. Precipitating substances to milk, barley, wheat, rye, oats, fraction 3 of gluten, and soy were present singly or in combination in all of the study patients. All patients responded to elimination of the offending antigen by return to normal bowel habits, weight gain, and elevation of hemoglobin and serum albumin values.

REFERENCES

Stanfield, J.P.:  Review of Cow's Milk Allergy in Infancy , Acta Paediat 48:85-99 ( (Jan) ) 1959;.
Goldman, A.S., et al:  Milk Allergy: I. Oral Challenge With Milk and Isolated Proteins in Allergic Children , Pediatrics 32: 425-443 ( (Sept) ) 1963;.
Rubin, M.:  Allergic Intestinal Bleeding in the Newborn , Amer J Med Sci 200:385-390 ( (Sept) ) 1948;.
Gryboski, J.D.:  Gastrointestinal Milk Allergy in Infants , Pediatrics 40:354-362 ( (Sept) ) 1968;.
Gryboski, J.D.; Burkle, F.; and Hillman, R.:  Milk-Induced Colitis in an Infant , Pediatrics 38:299-302 ( (Aug) ) 1966;.
Katz, J., et al:  Coproantibodies to Milk in Infants With Milk-Induced Gastrointestinal Bleeding , Clin Res 15:236 ( (April) ) 1967;.
Gryboski, J.D., et al:  Gluten Intolerance Following Cow's Milk Sensitivity , Ann Allerg 26:33-39 ( (Jan) ) 1968;.
Crowle, A.J.: Immunodiffusion , New York: Academic Press Inc., 1961;, p 333.
Crabbe, P.A.; Carbonara, A.O.; and Heremans, J.F.:  The Normal Human Intestinal Mucosa as a Major Source of Plasma Cells Containing Gamma A Immunoglobulin , Lab Invest 14: 235-248 ( (March) ) 1965;.
Tomasi, T.B., Jr., et al:  Characteristics of an Immune System Common to Certain External Secretions , J Exp Med 121:101-124 ( (Jan) ) 1965;.
Matthews, D.M., and Laster, L.:  Absorption of Protein Digestion Products: A Review , Gut 6:411-426 ( (Oct) ) 1965;.
South, M.A., et al:  The IgA System: II. The Clinical Significance of IgA Deficiency , Amer J Med 44:168-178 ( (Feb) ) 1968;.
Visakorpi, J.K., and Immonen, P.:  Intolerance to Cow's Milk and Wheat Gluten in the Primary Malabsorption Syndrome of Infancy , Acta Paediat Scand 56:49-56 ( (Jan) ) 1967;.
Ferrier, P.; Hampai, A.; and Baumgart, C.:  Evaluation du test au D-xylose chez l'enfant normal , Helv Pediat Acta 18:203-207 ( (June) ) 1963;.
Heiner, D.C., et al:  Precipitins to Antigens of Wheat and Cow's Milk in Celiac Disease , J Pediat 61:813-830 ( (Dec) ) 1962;.
Waldmann, T.A.,  Allergic Gastroenteropathy: A Cause of Excessive Gastrointestinal Protein Loss , New Eng J Med 276: 761-769 ( (April 6) ) 1967;.
Wilson, J.F.; Heiner, D.C.; and Lahey, M.E.:  Milk-Induced Gastrointestinal Bleeding in Infants With Hypochromic Microytic Anemia , JAMA 189:568-572 ( (Aug 17) ) 1964;.
Cook, C.D.:  Probable Gastrointestinal Reaction to Soybean , New Eng J Med 263:1076-1077 ( (Nov 24) ) 1960;.

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Stanfield, J.P.:  Review of Cow's Milk Allergy in Infancy , Acta Paediat 48:85-99 ( (Jan) ) 1959;.
Goldman, A.S., et al:  Milk Allergy: I. Oral Challenge With Milk and Isolated Proteins in Allergic Children , Pediatrics 32: 425-443 ( (Sept) ) 1963;.
Rubin, M.:  Allergic Intestinal Bleeding in the Newborn , Amer J Med Sci 200:385-390 ( (Sept) ) 1948;.
Gryboski, J.D.:  Gastrointestinal Milk Allergy in Infants , Pediatrics 40:354-362 ( (Sept) ) 1968;.
Gryboski, J.D.; Burkle, F.; and Hillman, R.:  Milk-Induced Colitis in an Infant , Pediatrics 38:299-302 ( (Aug) ) 1966;.
Katz, J., et al:  Coproantibodies to Milk in Infants With Milk-Induced Gastrointestinal Bleeding , Clin Res 15:236 ( (April) ) 1967;.
Gryboski, J.D., et al:  Gluten Intolerance Following Cow's Milk Sensitivity , Ann Allerg 26:33-39 ( (Jan) ) 1968;.
Crowle, A.J.: Immunodiffusion , New York: Academic Press Inc., 1961;, p 333.
Crabbe, P.A.; Carbonara, A.O.; and Heremans, J.F.:  The Normal Human Intestinal Mucosa as a Major Source of Plasma Cells Containing Gamma A Immunoglobulin , Lab Invest 14: 235-248 ( (March) ) 1965;.
Tomasi, T.B., Jr., et al:  Characteristics of an Immune System Common to Certain External Secretions , J Exp Med 121:101-124 ( (Jan) ) 1965;.
Matthews, D.M., and Laster, L.:  Absorption of Protein Digestion Products: A Review , Gut 6:411-426 ( (Oct) ) 1965;.
South, M.A., et al:  The IgA System: II. The Clinical Significance of IgA Deficiency , Amer J Med 44:168-178 ( (Feb) ) 1968;.
Visakorpi, J.K., and Immonen, P.:  Intolerance to Cow's Milk and Wheat Gluten in the Primary Malabsorption Syndrome of Infancy , Acta Paediat Scand 56:49-56 ( (Jan) ) 1967;.
Ferrier, P.; Hampai, A.; and Baumgart, C.:  Evaluation du test au D-xylose chez l'enfant normal , Helv Pediat Acta 18:203-207 ( (June) ) 1963;.
Heiner, D.C., et al:  Precipitins to Antigens of Wheat and Cow's Milk in Celiac Disease , J Pediat 61:813-830 ( (Dec) ) 1962;.
Waldmann, T.A.,  Allergic Gastroenteropathy: A Cause of Excessive Gastrointestinal Protein Loss , New Eng J Med 276: 761-769 ( (April 6) ) 1967;.
Wilson, J.F.; Heiner, D.C.; and Lahey, M.E.:  Milk-Induced Gastrointestinal Bleeding in Infants With Hypochromic Microytic Anemia , JAMA 189:568-572 ( (Aug 17) ) 1964;.
Cook, C.D.:  Probable Gastrointestinal Reaction to Soybean , New Eng J Med 263:1076-1077 ( (Nov 24) ) 1960;.
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