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Subacute Sclerosing Panencephalitis: Title and subTitle BreakA Multidisciplinary Study of Eight Cases FREE

J. T. Jabbour, MD; Julio H. Garcia, MD; Helio Lemmi, MD; James Ragland, PhD; Danilo A. Duenas, MD; John L. Sever, MD, PhD
[+] Author Affiliations

Reprint requests to 848 Adams, Memphis 38103 (Dr. Jabbour).


JAMA. 1969;207(12):2248-2254. doi:10.1001/jama.1969.03150250078007
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Clinical, electroencephalographic, and other laboratory features and subacute sclerosing panencephalitis (SSPE) were studied in eight patients by the same group of investigators. The relatively high frequency of the disease within a small geographical area in a short period of time suggests that SSPE may be unusually common in the vicinity of Memphis. The delineation of four clinical stages of the disease, markedly elevated measles antibody titers in serum and cerebrospinal fluid, ultrastructural observation of intranuclear and intracytoplasmic inclusions in neurons and neuroglia in three patients, and alteration of serum and CSF immunoglobulins indicate that the measles myxovirus may be the etiological agent in these patients.

REFERENCES

Dawson, J.R., Jr.:  Cellular Inclusions in Cerebral Lesions of Lethargic Encephalitis , Amer J Path 9:7-16 ( (Jan) ) 1933;.
 Conference on Measles Virus and Subacute Sclerosing Panencephalitis , Neurology 18 (pt (2) ), Jan 1968;, pp 1-192.
Legg, N.:  Virus Antibodies in Subacute Sclerosing Panencephalitis , Brit Med J 1:350-352 ( (Aug 5) ) 1967;.
Shaw, C.; Buchan, G.C.; and Carlson, C.B.:  Myxovirus as a Possible Etiologic Agent in Subacute Inclusion-Body Encephalitis , New Eng J Med 277:511-515 ( (Sept 7) ) 1967;.
Dayan, A.D., et al:  Evidence of a Pseudomyxovirus in the Brain in Subacute Sclerosing Leucoencephalitis , Lancet 1:980-981 ( (May 6) ) 1967;.
Sever, J.L., and Zeman, W.:  Serological Studies of Measles and Subacute Sclerosing Panencephalitis , Neurology 18 (pt (2) ), Jan 1968;, pp 95-97.
Connolly, J.H., et al:  Measles-Virus Antibody and Antigen in Subacute Sclerosing Panencephalitis , Lancet 1:542-544 ( (March 11) ) 1967;.
Bergmann, L., et al:  Cerebrospinal Fluid Gamma Globulins in Subacute Sclerosing Leukoencephalitis , J Neurochem 15:781-785 ( (Aug) ) 1968;.
Chao, D.:  Subacute Inclusion Body Encephalitis: Report of Three Cases , J Pediat 61:501-510 ( (Oct) ) 1962;.
Cobb, W.:  The Periodic Events of Subacute Sclerosing Leucoencephalitis , Electroenceph Clin Neurophysiol 21:278-294 ( (July) -Dec) 1966;.
Foley, J., and Williams, D.:  Inclusion Encephalitis and Its Relation to Subacute Sclerosing-Leucoencephalitis , Quart J Med 22:157-194 ( (April) ) 1953;.
Bouteille, M.; Kalifat, S.R.; and Delarue, J.:  Ultrastructural Variations of Nuclear Bodies in Human Diseases , J Ultrastruct Res 19:474-486 ( (May) ) 1967;.
Bouteille, M., et al:  Sur un cas d' encephalite subaigue a inclusions. Etude anatomoclinique et ultrastructurale , Rev Neurol 113:454-458 ( (Oct) ) 1965;.
Herndon, R.M., and Rubinstein, L.J.:  Light and Electron Microscopy Observations on the Development of Viral Particles in the Inclusions of Dawson's Encephalitis (Subacute Sclerosing Panencephalitis) , Neurology 18 (pt (2) ), Jan 1968;, pp 8-18.
Popoff, N., and Stewart, S.:  The Fine Structure of Nuclear Inclusions in the Brain of Experimental Golden Hamsters , read before the American Association of Neuropathologists, Washington, DC, June, 1968 .
Tellez-Nagel, I., and Harter, D.H.:  Subacute Sclerosing Leukoencephalitis: Ultrastructure of Intranuclear and Intracytoplasmic Inclusions , Science 154:899-900 ( (Nov 18) ) 1966;.
Gonatas, N.K.; Martin, J.; and Evangelista, I.:  The Osmiophilic Particles of Astrocytes , J Neuropath Exp Neurol 26:369-376 ( (July) ) 1967;.
Katz, M., et al:  Transmission of an Encephalitogenic Agent From Brains of Patients With Subacute Sclerosing Panencephalitis to Ferrets , New Eng J Med 279:793-798 ( (Oct 10) ) 1968;.

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Dawson, J.R., Jr.:  Cellular Inclusions in Cerebral Lesions of Lethargic Encephalitis , Amer J Path 9:7-16 ( (Jan) ) 1933;.
 Conference on Measles Virus and Subacute Sclerosing Panencephalitis , Neurology 18 (pt (2) ), Jan 1968;, pp 1-192.
Legg, N.:  Virus Antibodies in Subacute Sclerosing Panencephalitis , Brit Med J 1:350-352 ( (Aug 5) ) 1967;.
Shaw, C.; Buchan, G.C.; and Carlson, C.B.:  Myxovirus as a Possible Etiologic Agent in Subacute Inclusion-Body Encephalitis , New Eng J Med 277:511-515 ( (Sept 7) ) 1967;.
Dayan, A.D., et al:  Evidence of a Pseudomyxovirus in the Brain in Subacute Sclerosing Leucoencephalitis , Lancet 1:980-981 ( (May 6) ) 1967;.
Sever, J.L., and Zeman, W.:  Serological Studies of Measles and Subacute Sclerosing Panencephalitis , Neurology 18 (pt (2) ), Jan 1968;, pp 95-97.
Connolly, J.H., et al:  Measles-Virus Antibody and Antigen in Subacute Sclerosing Panencephalitis , Lancet 1:542-544 ( (March 11) ) 1967;.
Bergmann, L., et al:  Cerebrospinal Fluid Gamma Globulins in Subacute Sclerosing Leukoencephalitis , J Neurochem 15:781-785 ( (Aug) ) 1968;.
Chao, D.:  Subacute Inclusion Body Encephalitis: Report of Three Cases , J Pediat 61:501-510 ( (Oct) ) 1962;.
Cobb, W.:  The Periodic Events of Subacute Sclerosing Leucoencephalitis , Electroenceph Clin Neurophysiol 21:278-294 ( (July) -Dec) 1966;.
Foley, J., and Williams, D.:  Inclusion Encephalitis and Its Relation to Subacute Sclerosing-Leucoencephalitis , Quart J Med 22:157-194 ( (April) ) 1953;.
Bouteille, M.; Kalifat, S.R.; and Delarue, J.:  Ultrastructural Variations of Nuclear Bodies in Human Diseases , J Ultrastruct Res 19:474-486 ( (May) ) 1967;.
Bouteille, M., et al:  Sur un cas d' encephalite subaigue a inclusions. Etude anatomoclinique et ultrastructurale , Rev Neurol 113:454-458 ( (Oct) ) 1965;.
Herndon, R.M., and Rubinstein, L.J.:  Light and Electron Microscopy Observations on the Development of Viral Particles in the Inclusions of Dawson's Encephalitis (Subacute Sclerosing Panencephalitis) , Neurology 18 (pt (2) ), Jan 1968;, pp 8-18.
Popoff, N., and Stewart, S.:  The Fine Structure of Nuclear Inclusions in the Brain of Experimental Golden Hamsters , read before the American Association of Neuropathologists, Washington, DC, June, 1968 .
Tellez-Nagel, I., and Harter, D.H.:  Subacute Sclerosing Leukoencephalitis: Ultrastructure of Intranuclear and Intracytoplasmic Inclusions , Science 154:899-900 ( (Nov 18) ) 1966;.
Gonatas, N.K.; Martin, J.; and Evangelista, I.:  The Osmiophilic Particles of Astrocytes , J Neuropath Exp Neurol 26:369-376 ( (July) ) 1967;.
Katz, M., et al:  Transmission of an Encephalitogenic Agent From Brains of Patients With Subacute Sclerosing Panencephalitis to Ferrets , New Eng J Med 279:793-798 ( (Oct 10) ) 1968;.
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