0
ARTICLE |

Cytogenetic Effects of LSD 25 Therapy in Man FREE

David A. Hungerford, PhD; Kenneth M. Taylor, PhD; Charles Shagass, MD; Gundula U. LaBadie; Gloria B. Balaban, MA; Gillian R. Paton
[+] Author Affiliations

Reprint requests to 7701 Burholme Ave, Philadephia 19111 (Dr. Hungerford).


JAMA. 1968;206(10):2287-2291. doi:10.1001/jama.1968.03150100037008
Text Size: A A A
Published online

Chromosomes have been studied in leukocytes cultured from patients undergoing experimental therapy with lysergic acid diethylamide (LSD 25). Aberration frequencies prior to therapy were established for three of the four patients; these were comparable to frequencies in control subjects. Following each of three doses given intravenously (usually 200ÎĽg per dose), each patient's chromosomes were reexamined. Some increase in aberration frequency was observed, along with the appearance of some types of aberration not present before treatment. However, a return to control levels occurred in follow-up samples taken one to six months after the final dose was administered. We feel therefore that continued experimental therapy is not strongly contraindicated. On the other hand, these results can not be construed to minimize the possible cytogenetic hazards suggested by other studies concerned primarily with drug abuse.

REFERENCES

Cohen, M.M.; Marinello, M.J., and Back. N.:  Chromosomal Damage in Human Leukocytes Induced by Lysergic Acid Diethylamide . Science 155:1417-1419 ( (March 17) ) 1967;.
Eggert, D.C., and Shagass, C.:  Clinical Prediction of Insightful Response to a Single Large Dose of LSD , Psychopharmacologia 9:340-346, 1966;.
Shagass, C., and Bittle, R.M.:  Therapeutic Effects of LSD: A Follow-Up Study , J Nerv Ment Dis 144:471-478 ( (June) ) 1967;.
" Chicago Conference: Standardization in Human Cytogenetics ," Birth Defects: Original Article Series . New York: The National Foundation—March of Dimes. (December) 1966;. vol 2.
Hungerford, D.A.:  Leukocytes Cultured From Small Inocula of Whole Blood and the Preparation of Metaphase Chromosomes by Treatment With Hypotonic KCl , Stain Techn 40:333-338 ( (Nov) ) 1965;.
Evans, H.J.; Court-Brown, W.M.; and McLaine, A.S. (eds.): Human Radiation Cytogenetics , Amsterdam: North-Holland, 1967;.
Jacobs, P.A.; Brunton, M.; and Court-Brown, W.M.:  Cytogenetic Studies in Leucocytes on the General Population: Subjects of Ages 65 Years and More , Ann Hum Genet 27:353-362 ( (June) ) 1964;.
Nusbacher, J.; Hirschhorn, K.; and Cooper, L.Z.:  Chromosomal Abnormalities in Congenital Rubella . New Eng J Med 276:1409-1413 ( (June 22) ) 1967;.
Cohen, M.M.; Hirschhorn, K.; and Frosch. W.A.:  In Vivo and in Vitro Chromosomal Damage Induced by LSD-25 , New Eng J Med 277:1043-1049 ( (Nov 16) ) 1967;.
Jarvik, L.F., and Kato, T.:  Is Lysergide a Teratogen? Lancet 1:250 ( (Feb 3) ) 1968;.
Ostertag, W., and Haake, J.:  The Mutagenicity in Drosophila melanogaster of Caffeine and of Other Compounds Which Produce Chromosome Breakage in Human Cells in Culture , Z Vererbungsl 98:299-308 ( (Dec) ) 1966;.
Irwin, S., and Egozcue, J.:  Chromosomal Abnormalities in Leukocytes From LSD-25 Users , Science 157:313-314 ( (July 21) ) 1967;.
Egozcue, J.; Irwin, S.; and Maruffo, C.A.:  Chromosomal Damage in LSD Users , JAMA 204:214-218 ( (April 15) ) 1968;.
Loughman, W.D.: Sargent, T.W.; and Israelstam, D.M.:  Leukocytes of Humans Exposed to Lysergic Acid Diethylamide: Lack of Chromosomal Damage , Science 158:508-510 ( (Oct 27) ) 1967;.
Sparkes. R.S.; Melnyk, J.; and Bozzetti, L.P.:  Chromosomal Effect in Vivo of Exposure to Lysergic Acid Diethylamide , Science 160:1343-1345 ( (June 21) ) 1968;.
Smith, D.E.. and Rose, A.J.:  Observations in the Haight-Ashbury Medical Clinic of San Francisco: Health Problems in a "Hippie" Subculture , Clin Pediat 7:313-316 ( (June) ) 1968;.
Bender, L., Siva-Sankar, D.V.:  Chromosome Damage Not Found in Leukocytes of Children Treated With LSD 25 , Science 159:749 ( (Feb 16) ) 1968;.
Nielsen. J.; Friedrich, U.: and Tsuboi, T.:  Chromosome Abnormalities and Psychotropic Drugs , Nature 218:488-489 ( (May 4) ) 1968;.
Skakkebaek, N.E.; Philip, J.; and Rafaelsen, O.J.:  LSD in Mice: Abnormalities in Meiotic Chromosomes , Science 160:1246-1248 ( (June 14) ) 1968;.
Sato, H., and Pergament, E.:  Is Lysergide a Teratogen? Lancet 1:639-640 ( (March 23) ) 1968;.
Zellweger, H.; McDonald, J.S.; and Abbo, G.:  Is Lysergic-Acid Diethylamide a Teratogen? Lancet 2:1066-1068 ( (Nov 18) ) 1967;.
Alexander, G.J., et al:  LSD: Injection Early in Pregnancy Produces Abnormalities in Offspring of Rats , Science 157:459-461 ( (July 28) ) 1967;.
Warkany, J., and Takacs, E.:  Lysergic Acid Diethylamide (LSD): No Teratogenicity in Rats . Science 159:731-732 ( (Feb 16) ) 1968;.
Auerbach, R., and Rugowski, J.A.:  Lysergic Acid Diethylamide: Effect on Embryos . Science 157:1325-1326 ( (Sept 15) ) 1967;.
Geber, W.F.:  Congenital Malformations Induced by Mescaline, Lysergic Acid Diethylamide, and Bromolysergic Acid in the Hamster . Science 158:265-267 ( (Oct 13) ) 1967;.
Fabro. S., and Sieber, S.M.:  Is Lysergide a Teratogen? Lancet 1:639 ( (March 23) ) 1968;.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Cohen, M.M.; Marinello, M.J., and Back. N.:  Chromosomal Damage in Human Leukocytes Induced by Lysergic Acid Diethylamide . Science 155:1417-1419 ( (March 17) ) 1967;.
Eggert, D.C., and Shagass, C.:  Clinical Prediction of Insightful Response to a Single Large Dose of LSD , Psychopharmacologia 9:340-346, 1966;.
Shagass, C., and Bittle, R.M.:  Therapeutic Effects of LSD: A Follow-Up Study , J Nerv Ment Dis 144:471-478 ( (June) ) 1967;.
" Chicago Conference: Standardization in Human Cytogenetics ," Birth Defects: Original Article Series . New York: The National Foundation—March of Dimes. (December) 1966;. vol 2.
Hungerford, D.A.:  Leukocytes Cultured From Small Inocula of Whole Blood and the Preparation of Metaphase Chromosomes by Treatment With Hypotonic KCl , Stain Techn 40:333-338 ( (Nov) ) 1965;.
Evans, H.J.; Court-Brown, W.M.; and McLaine, A.S. (eds.): Human Radiation Cytogenetics , Amsterdam: North-Holland, 1967;.
Jacobs, P.A.; Brunton, M.; and Court-Brown, W.M.:  Cytogenetic Studies in Leucocytes on the General Population: Subjects of Ages 65 Years and More , Ann Hum Genet 27:353-362 ( (June) ) 1964;.
Nusbacher, J.; Hirschhorn, K.; and Cooper, L.Z.:  Chromosomal Abnormalities in Congenital Rubella . New Eng J Med 276:1409-1413 ( (June 22) ) 1967;.
Cohen, M.M.; Hirschhorn, K.; and Frosch. W.A.:  In Vivo and in Vitro Chromosomal Damage Induced by LSD-25 , New Eng J Med 277:1043-1049 ( (Nov 16) ) 1967;.
Jarvik, L.F., and Kato, T.:  Is Lysergide a Teratogen? Lancet 1:250 ( (Feb 3) ) 1968;.
Ostertag, W., and Haake, J.:  The Mutagenicity in Drosophila melanogaster of Caffeine and of Other Compounds Which Produce Chromosome Breakage in Human Cells in Culture , Z Vererbungsl 98:299-308 ( (Dec) ) 1966;.
Irwin, S., and Egozcue, J.:  Chromosomal Abnormalities in Leukocytes From LSD-25 Users , Science 157:313-314 ( (July 21) ) 1967;.
Egozcue, J.; Irwin, S.; and Maruffo, C.A.:  Chromosomal Damage in LSD Users , JAMA 204:214-218 ( (April 15) ) 1968;.
Loughman, W.D.: Sargent, T.W.; and Israelstam, D.M.:  Leukocytes of Humans Exposed to Lysergic Acid Diethylamide: Lack of Chromosomal Damage , Science 158:508-510 ( (Oct 27) ) 1967;.
Sparkes. R.S.; Melnyk, J.; and Bozzetti, L.P.:  Chromosomal Effect in Vivo of Exposure to Lysergic Acid Diethylamide , Science 160:1343-1345 ( (June 21) ) 1968;.
Smith, D.E.. and Rose, A.J.:  Observations in the Haight-Ashbury Medical Clinic of San Francisco: Health Problems in a "Hippie" Subculture , Clin Pediat 7:313-316 ( (June) ) 1968;.
Bender, L., Siva-Sankar, D.V.:  Chromosome Damage Not Found in Leukocytes of Children Treated With LSD 25 , Science 159:749 ( (Feb 16) ) 1968;.
Nielsen. J.; Friedrich, U.: and Tsuboi, T.:  Chromosome Abnormalities and Psychotropic Drugs , Nature 218:488-489 ( (May 4) ) 1968;.
Skakkebaek, N.E.; Philip, J.; and Rafaelsen, O.J.:  LSD in Mice: Abnormalities in Meiotic Chromosomes , Science 160:1246-1248 ( (June 14) ) 1968;.
Sato, H., and Pergament, E.:  Is Lysergide a Teratogen? Lancet 1:639-640 ( (March 23) ) 1968;.
Zellweger, H.; McDonald, J.S.; and Abbo, G.:  Is Lysergic-Acid Diethylamide a Teratogen? Lancet 2:1066-1068 ( (Nov 18) ) 1967;.
Alexander, G.J., et al:  LSD: Injection Early in Pregnancy Produces Abnormalities in Offspring of Rats , Science 157:459-461 ( (July 28) ) 1967;.
Warkany, J., and Takacs, E.:  Lysergic Acid Diethylamide (LSD): No Teratogenicity in Rats . Science 159:731-732 ( (Feb 16) ) 1968;.
Auerbach, R., and Rugowski, J.A.:  Lysergic Acid Diethylamide: Effect on Embryos . Science 157:1325-1326 ( (Sept 15) ) 1967;.
Geber, W.F.:  Congenital Malformations Induced by Mescaline, Lysergic Acid Diethylamide, and Bromolysergic Acid in the Hamster . Science 158:265-267 ( (Oct 13) ) 1967;.
Fabro. S., and Sieber, S.M.:  Is Lysergide a Teratogen? Lancet 1:639 ( (March 23) ) 1968;.
CME Course for:


You need to register in order to view this quiz.


To understand the clinical management of acute heart failure syndromes.
Accreditation Information The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
To view and print your certificate and access a summary of your CME courses go to My CME.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Response

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.