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July 29, 1968, Vol 205, No. 5 >
ARTICLE | July 29, 1968

A New Method of Measuring Coronary Blood Flow in Man FREE

Richard J. Bing, MD; Charles Cowan, MD; Dedo Bottcher, MD; Giancarlo Corsini, MD; Clarke G. Daniels, MD
[+] Author Affiliations

Presented as a scientific exhibit at the 21st clinical convention of the American Medical Association, Houston, Nov 21-29, 1967.

Reprint requests to 1400 Chrysler Freeway, Detroit 48207 (Dr. Bing).


JAMA. 1968;205(5):277-280. doi:10.1001/jama.1968.03140310035007
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A new, practical method of clinical measurement of coronary blood flow (CBF) has proved its value with use on more than 1,000 patients. Demonstrated also is the relation of CBF to other cardiac dynamics and the comparative influence of some pharmacologic agents on CBF. This method of measuring coronary blood flow introduces new principles, the use of rubidium Rb 84, which is a positron emitter, and the use of coincidence counting.1

This quantitative method promises to be of help in the diagnosis of coronary artery disease. It permits measurement of the effects of antianginal and antihypertensive drugs on the coronary circulation in normal patients and in patients with arteriosclerotic heart disease. Catheterization of the coronary sinus is not required.

Concept  The contractile function and nutrition of the heart muscle, the myocardium, depends upon an almost continuous adequate CBF. The coronary arteries alone supply most of the blood to the

REFERENCES

1 +
Bing, R.J., et al:  The Determination of Coronary Flow Equivalent With Coincidence Counting Technic , Circulation 29: 833-846 ( (June) ) 1964;.
2 +
Cohen, A., et al:  The Use of Positron Emitter in the Determination of Coronary Blood Flow in Man , J Nucl Med 6:651-666 ( (Sept) ) 1965;.
3 +
Robin, E., et al:  A Comparative Study of Nitroglycerin and Propranolol , Circulation 36:175-186 ( (Aug) ) 1967;.
4 +
Madeira, R.G., et al:  Measurement of the Shortening of Cardiac Fibers in Man , Amer J Cardiol 19:686-691 ( (May) ) 1967;.
5 +
Cohen, A., et al:  Effects of Alpha-Methyldopa on the Myocardial Blood Flow, Utilizing the Coincidence Counting Method , J Clin Pharmacol 7:77-83 ( (March) -April) 1967;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Bing, R.J., et al:  The Determination of Coronary Flow Equivalent With Coincidence Counting Technic , Circulation 29: 833-846 ( (June) ) 1964;.
2 +
Cohen, A., et al:  The Use of Positron Emitter in the Determination of Coronary Blood Flow in Man , J Nucl Med 6:651-666 ( (Sept) ) 1965;.
3 +
Robin, E., et al:  A Comparative Study of Nitroglycerin and Propranolol , Circulation 36:175-186 ( (Aug) ) 1967;.
4 +
Madeira, R.G., et al:  Measurement of the Shortening of Cardiac Fibers in Man , Amer J Cardiol 19:686-691 ( (May) ) 1967;.
5 +
Cohen, A., et al:  Effects of Alpha-Methyldopa on the Myocardial Blood Flow, Utilizing the Coincidence Counting Method , J Clin Pharmacol 7:77-83 ( (March) -April) 1967;.

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