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ARTICLE |

Procarbazine Therapy for Hodgkin's Disease in Early Pregnancy FREE

James H. Wells, MD; John R. Marshall, MD; Paul P. Carbone, MD
[+] Author Affiliations

Reprint requests to National Cancer Institute, Bethesda. Md 20014 (Dr. Carbone).


JAMA. 1968;205(13):935-937. doi:10.1001/jama.1968.03140390059020
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Procarbazine hydrochloride, an antineoplastic agent, a teratogen, and a carcinogen, was given to a patient with Hodgkin's disease during the first 5 1/2 weeks of her pregnancy, and a normal infant was delivered. Based on past experience with chemotherapeutic agents given to pregnant women with Hodgkin's disease, the authors present a program of management for the pregnant patient with Hodgkin's disease.

REFERENCES

Chaube, S., and Murphy, M.L.:  The Teratogenic Effects of 1-Methyl-2-Para (Isopropylcarbamoyl) Benzyl Hydrazine , Proc Amer Assoc Cancer Res 5:11 ( (March) ) 1964;.
Kelly, M.G., et al:  Carcinogenic Activity of a New Antitumor Agent, N-Isopropyl-α(2-Methyl Hydrazino)-p-Toluamide Hydrochloride (NSC-77213) , Cancer Chemother Rep 39:77-80 ( (July) ) 1964;.
Mathe, G., et al:  Methylhydrazine in Treatment of Hodgkin's Disease , Lancet 2:1077-1080 ( (Nov 23) ) 1963;.
Murphy, M.L.; Moro, A.D.; and Lacon, C.:  The Comparative Effects of Five Polyfunctional Alkylating Agents on the Rat Fetus, With Additional Notes on the Chick Embryo , Ann NY Acad Sci 68:762-781 ( (April 24) ) 1958;.
Ferm, V.H.:  Congenital Malformations in Hamster Embryos After Treatment With Vinblastine and Vincristine , Science 141:426 ( (Aug 2) ) 1963;.
Shotton, D., and Monie, I.W.:  Possible Teratogenic Effect of Chlorambucil on a Human Fetus , JAMA 186:74-75, ( (Oct 5) ) 1963;.
Greenberg, L.H., and Tanaka, K.R.:  Congenital Anomalies Probably Induced by Cyclophosphamide , JAMA 188:423-426, ( (May 4) ) 1964;.
Barry, R.M.; Diamond, H.D.; and Craver, L.F.:  Influence of Pregnancy on the Course of Hodgkin's Disease , Amer J Obstet Gynec 84:445-454 ( (Aug 15) ) 1962;.
Boland, J.:  Reticuloses: Clinical Experience With Nitrogen Mustard in Hodgkin's Disease , Brit J Radiol 24:513-515 ( (Sept) ) 1951;.
Zoet, A.G.:  Pregnancy Complicating Hodgkin's Disease , Northwest Med 49:373-374 ( (June) ) 1950;.
Smith, R.B.W.; Sheeky, T.W.; and Rothberg, H.:  Hodgkin's Disease and Pregnancy , Arch Intern Med 102:777-789 ( (Nov) ) 1958;.
Wright, J.C., et al:  The Effect of Tri-ethylene Melamine and of Tri-ethylene Phosphoramide in Human Neo-Plastic Diseases , Acta Un Int Cancr 11:220-257, 1955;.
Rosenzweig, A.I.; Crews, Q.E., Jr.; and Hopwood, H.G.:  Vinblastine Sulfate in Hodgkin's Disease in Pregnancy , Ann Intern Med 61:108-112 ( (July) ) 1964;.
Armstrong, J.G., et al:  Delivery of a Normal Infant During the Course of Oral Vinblastine Sulfate Therapy for Hodgkin's Disease , Ann Intern Med 61:106-107 ( (July) ) 1964;.
Hennessy, J.P., and Bottino, A.:  Hodgkin's Disease in Pregnancy , Amer J Obstet Gynec 87:851-853 ( (Dec 1) ) 1963;.

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Chaube, S., and Murphy, M.L.:  The Teratogenic Effects of 1-Methyl-2-Para (Isopropylcarbamoyl) Benzyl Hydrazine , Proc Amer Assoc Cancer Res 5:11 ( (March) ) 1964;.
Kelly, M.G., et al:  Carcinogenic Activity of a New Antitumor Agent, N-Isopropyl-α(2-Methyl Hydrazino)-p-Toluamide Hydrochloride (NSC-77213) , Cancer Chemother Rep 39:77-80 ( (July) ) 1964;.
Mathe, G., et al:  Methylhydrazine in Treatment of Hodgkin's Disease , Lancet 2:1077-1080 ( (Nov 23) ) 1963;.
Murphy, M.L.; Moro, A.D.; and Lacon, C.:  The Comparative Effects of Five Polyfunctional Alkylating Agents on the Rat Fetus, With Additional Notes on the Chick Embryo , Ann NY Acad Sci 68:762-781 ( (April 24) ) 1958;.
Ferm, V.H.:  Congenital Malformations in Hamster Embryos After Treatment With Vinblastine and Vincristine , Science 141:426 ( (Aug 2) ) 1963;.
Shotton, D., and Monie, I.W.:  Possible Teratogenic Effect of Chlorambucil on a Human Fetus , JAMA 186:74-75, ( (Oct 5) ) 1963;.
Greenberg, L.H., and Tanaka, K.R.:  Congenital Anomalies Probably Induced by Cyclophosphamide , JAMA 188:423-426, ( (May 4) ) 1964;.
Barry, R.M.; Diamond, H.D.; and Craver, L.F.:  Influence of Pregnancy on the Course of Hodgkin's Disease , Amer J Obstet Gynec 84:445-454 ( (Aug 15) ) 1962;.
Boland, J.:  Reticuloses: Clinical Experience With Nitrogen Mustard in Hodgkin's Disease , Brit J Radiol 24:513-515 ( (Sept) ) 1951;.
Zoet, A.G.:  Pregnancy Complicating Hodgkin's Disease , Northwest Med 49:373-374 ( (June) ) 1950;.
Smith, R.B.W.; Sheeky, T.W.; and Rothberg, H.:  Hodgkin's Disease and Pregnancy , Arch Intern Med 102:777-789 ( (Nov) ) 1958;.
Wright, J.C., et al:  The Effect of Tri-ethylene Melamine and of Tri-ethylene Phosphoramide in Human Neo-Plastic Diseases , Acta Un Int Cancr 11:220-257, 1955;.
Rosenzweig, A.I.; Crews, Q.E., Jr.; and Hopwood, H.G.:  Vinblastine Sulfate in Hodgkin's Disease in Pregnancy , Ann Intern Med 61:108-112 ( (July) ) 1964;.
Armstrong, J.G., et al:  Delivery of a Normal Infant During the Course of Oral Vinblastine Sulfate Therapy for Hodgkin's Disease , Ann Intern Med 61:106-107 ( (July) ) 1964;.
Hennessy, J.P., and Bottino, A.:  Hodgkin's Disease in Pregnancy , Amer J Obstet Gynec 87:851-853 ( (Dec 1) ) 1963;.
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