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Resuscitation From Ventricular Fibrillation: Title and subTitle BreakDrug Therapy FREE

Joseph S. Redding, MD; John W. Pearson, MD
[+] Author Affiliations

Read before the Section on Anesthesiology at the 116th annual convention of the American Medical Association, Atlantic City, NJ, June 21, 1967.

Reprint requests to 4940 Eastern Ave, Baltimore 21224 (Dr. Redding).


JAMA. 1968;203(4):255-260. doi:10.1001/jama.1968.03140040007002
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In resuscitating dogs subjected to ten minutes of circulatory arrest due to ventricular fibrillation, a number of drugs were used with artificial ventilation of the lungs, external cardiac massage, and external electrical counter-shock. Resuscitation was more successful when epinephrine was used than when no drug therapy or sodium bicarbonate were used. Combination of lidocaine with epinephrine increased the frequency of defibrillation, but circulation was not restored more often than with epinephrine alone. The use of methoxamine hydrochloride was followed by successful resuscitation more often than was the use of epinephrine. Combination of epinephrine and sodium bicarbonate was as effective as methoxamine in restoring circulation, and inspection of the survivors after 24 hours suggested that the combination might be preferable.

REFERENCES

Redding, J.S., and Pearson, J.W.:  Evaluation of Drugs for Cardiac Resuscitation , Anesthesiology 24:203-207 ( (March) -April) 1963;.
Redding, J.S., and Pearson, J.W.:  Resuscitation From Asphyxia , JAMA 182:283-286 ( (Oct 20) ) 1962;.
Pearson, J.W., and Redding, J.S.:  Influence of Peripheral Vascular Tone on Cardiac Resuscitation , Anesth Analg 44:746-752 ( (Nov) -Dec) 1965;.
Redding, J.S., and Pearson, J.W.:  Metabolic Acidosis: A Factor in Cardiac Resuscitation , Southern Med J 60:926-932 ( (Sept) ) 1967;.
Harden, K.; Mackenzie, I.L.; and Ledingham, I.M.:  Spontaneous Reversion of Ventricular Fibrillation , Lancet 2:1140-1142 ( (Nov 30) ) 1963;.
Brooks, D.K., and Feldman, S.A.:  Metabolic Acidosis: A New Approach to Neostigmine Resistant Curarisation , Anaes thesia 17:161-169 ( (April) ) 1962;.
Gerst, P.H.; Fleming, W.H.; and Malm, J.R.:  Increased Susceptibility of the Heart to Ventricular Fibrillation During Metabolic Acidosis , Circ Res 19:63-70 ( (July) ) 1966;.
Sewell, W.H.; Koth, D.R.; and Huggins, C.E.:  Ventricular Fibrillation in Dogs After Sudden Return of Flow to the Coronary Artery , Surgery 38:1050-1053 ( (Dec) ) 1955;.
Wexler, J., and Patt, H.H.:  Evidence That Serum Potassium Is Not the Etiological Agent in Ventricular Fibrillation Following Coronary Artery Occlusion , Amer Heart J 60:618-623 ( (Oct) ) 1960;.
Moore, R.M., and Greenberg, M.M.:  Acid Production in the Functioning Heart Under Conditions of Ischemia and of Congestion , Amer J Physiol 118:217-224 ( (Feb) ) 1937;.

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Redding, J.S., and Pearson, J.W.:  Evaluation of Drugs for Cardiac Resuscitation , Anesthesiology 24:203-207 ( (March) -April) 1963;.
Redding, J.S., and Pearson, J.W.:  Resuscitation From Asphyxia , JAMA 182:283-286 ( (Oct 20) ) 1962;.
Pearson, J.W., and Redding, J.S.:  Influence of Peripheral Vascular Tone on Cardiac Resuscitation , Anesth Analg 44:746-752 ( (Nov) -Dec) 1965;.
Redding, J.S., and Pearson, J.W.:  Metabolic Acidosis: A Factor in Cardiac Resuscitation , Southern Med J 60:926-932 ( (Sept) ) 1967;.
Harden, K.; Mackenzie, I.L.; and Ledingham, I.M.:  Spontaneous Reversion of Ventricular Fibrillation , Lancet 2:1140-1142 ( (Nov 30) ) 1963;.
Brooks, D.K., and Feldman, S.A.:  Metabolic Acidosis: A New Approach to Neostigmine Resistant Curarisation , Anaes thesia 17:161-169 ( (April) ) 1962;.
Gerst, P.H.; Fleming, W.H.; and Malm, J.R.:  Increased Susceptibility of the Heart to Ventricular Fibrillation During Metabolic Acidosis , Circ Res 19:63-70 ( (July) ) 1966;.
Sewell, W.H.; Koth, D.R.; and Huggins, C.E.:  Ventricular Fibrillation in Dogs After Sudden Return of Flow to the Coronary Artery , Surgery 38:1050-1053 ( (Dec) ) 1955;.
Wexler, J., and Patt, H.H.:  Evidence That Serum Potassium Is Not the Etiological Agent in Ventricular Fibrillation Following Coronary Artery Occlusion , Amer Heart J 60:618-623 ( (Oct) ) 1960;.
Moore, R.M., and Greenberg, M.M.:  Acid Production in the Functioning Heart Under Conditions of Ischemia and of Congestion , Amer J Physiol 118:217-224 ( (Feb) ) 1937;.
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