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Alloalbuminemia: Title and subTitle BreakAlbumin Naskapi in Indians of the Ungava FREE

Baruch S. Blumberg, MD; John R. Martin, MD; Liisa Melartin, MD
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JAMA. 1968;203(3):180-185. doi:10.1001/jama.1968.03140030012003
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Alloalbuminemia is a condition in which the individual has an albumin variant different from common albumin (albumin A). Clinical examinations were performed on Naskapi and Montagnais Indians homozygous and heterozygous for an inherited albumin variant, albumin Naskapi, common in several North American Indian tribes but absent in other populations. None of the individuals with albumin Naskapi appears to have clinical or laboratory findings which could be ascribed to alloalbuminemia. Many physiological materials, dyes, and drugs bind to serum albumin, and some of these bind differentially to the albumin variants. This could be of clinical importance in American Indians.

REFERENCES

Laurell, C.B., and Niléhn, J.E.:  A New Type of Inherited Serum Albumin Anomaly , J Clin Invest 45:1935-1945 ( (Dec) ) 1966;.
Efremov, G., and Braend, M.:  Serum Albumin: Polymorphism in Man , Science 146:1679-1680 ( (Dec 25) ) 1964;.
Earle, D.P., et al:  Observations on Double Albumin: A Genetically Transmitted Serum Protein Anomaly , J Clin Invest 38:1412-1420 ( (Sept) ) 1959;.
Tárnoky, A.L., and Lestas, A.N.:  A New Type of Bisalbuminemia , Clin Chim Acta 9:551-558, 1964;.
Scheurlen, P.G.:  Ueber Serumeiweissveränderungen beim Diabetes Mellitus , Klin Wschr 33:198-205 ( (March) ) 1955;.
Gabl, F., and Huber, E.G.:  Passagere, nicht Hereditäre Doppelalbuminämie , Ann Paediat 202:81-91, 1964;.
Gitlin, D., et al:  Observations on Double Albumin: II. A Peptide Difference Between Two Genetically Determined Human Serum Albumis , J Clin Invest 40:820-827 ( (May) ) 1961;.
Wieme, R.J.:  On the Presence of Two Albumins in Certain Normal Human Sera and Its Genetic Determination , Clin Chim Acta 5:443-445, 1960;.
Melartin, L., and Blumberg, B.S.:  Albumin Naskapi, a New Variant of Serum Albumin , Science 153:1664-1666 ( (Sept 30) ) 1966;.
Bell, H.E., et al:  Bisalbuminemia of the Fast Type With a Homozygote , Clin Chim Acta 15:247-252, 1967;.
Melartin, L.:  Albumin Polymorphism in Man: Studies on Albumin Variants in North American Native Populations , Acta Path Microbiol Scand , to be published.
Blumberg, B.S., et al:  Blood Groups of the Naskapi and Montagnais Indians of Schefferville, Quebec , Hum Biol 36:263-272 ( (Sept) ) 1964;.
Ashton, G.C., and Braden, A.W.H.:  Serum β-globulin Polymorphism in Mice , Aust J Biol Sci 14:248-253 ( (April) ) 1961;.
Melartin, L., and Blumberg, B.S.:  Inherited Variants of Human Serum Albumin , Clin Res 14 , (Dec 13) , 1966;, adv p 48.
Melartin, L.; Blumberg, B.S.; and Lisker, R.:  Albumin Mexico: A New Variant of Serum Albumin , Nature 115:1288-1289 ( (Sept 16) ) 1967;.
Weitkamp, L.R., et al:  Genetic Linkage Between Structural Loci for Albumin and Group Specific Component (Gc) , Amer J Hum Genet , (July) 1967;, pp 559-571.
Blumberg, B.S.; Kaarsalo, E.: and Melartin, L.:  Autosomal Linkage Between Albumin and Gc Loci , Clin Res 14:481 ( (Dec 13) ) 1966;.
Kaarsalo, E.; Melartin, L.; and Blumberg, B.S.:  Autosomal Linkage Between the Albumin and Gc Loci in Humans , Science , 158:123-125 ( (Oct 6) ) 1967;.
Hirschfeld, J.:  The Gc-system , Progr Allerg 6:155-186, 1962;.

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Laurell, C.B., and Niléhn, J.E.:  A New Type of Inherited Serum Albumin Anomaly , J Clin Invest 45:1935-1945 ( (Dec) ) 1966;.
Efremov, G., and Braend, M.:  Serum Albumin: Polymorphism in Man , Science 146:1679-1680 ( (Dec 25) ) 1964;.
Earle, D.P., et al:  Observations on Double Albumin: A Genetically Transmitted Serum Protein Anomaly , J Clin Invest 38:1412-1420 ( (Sept) ) 1959;.
Tárnoky, A.L., and Lestas, A.N.:  A New Type of Bisalbuminemia , Clin Chim Acta 9:551-558, 1964;.
Scheurlen, P.G.:  Ueber Serumeiweissveränderungen beim Diabetes Mellitus , Klin Wschr 33:198-205 ( (March) ) 1955;.
Gabl, F., and Huber, E.G.:  Passagere, nicht Hereditäre Doppelalbuminämie , Ann Paediat 202:81-91, 1964;.
Gitlin, D., et al:  Observations on Double Albumin: II. A Peptide Difference Between Two Genetically Determined Human Serum Albumis , J Clin Invest 40:820-827 ( (May) ) 1961;.
Wieme, R.J.:  On the Presence of Two Albumins in Certain Normal Human Sera and Its Genetic Determination , Clin Chim Acta 5:443-445, 1960;.
Melartin, L., and Blumberg, B.S.:  Albumin Naskapi, a New Variant of Serum Albumin , Science 153:1664-1666 ( (Sept 30) ) 1966;.
Bell, H.E., et al:  Bisalbuminemia of the Fast Type With a Homozygote , Clin Chim Acta 15:247-252, 1967;.
Melartin, L.:  Albumin Polymorphism in Man: Studies on Albumin Variants in North American Native Populations , Acta Path Microbiol Scand , to be published.
Blumberg, B.S., et al:  Blood Groups of the Naskapi and Montagnais Indians of Schefferville, Quebec , Hum Biol 36:263-272 ( (Sept) ) 1964;.
Ashton, G.C., and Braden, A.W.H.:  Serum β-globulin Polymorphism in Mice , Aust J Biol Sci 14:248-253 ( (April) ) 1961;.
Melartin, L., and Blumberg, B.S.:  Inherited Variants of Human Serum Albumin , Clin Res 14 , (Dec 13) , 1966;, adv p 48.
Melartin, L.; Blumberg, B.S.; and Lisker, R.:  Albumin Mexico: A New Variant of Serum Albumin , Nature 115:1288-1289 ( (Sept 16) ) 1967;.
Weitkamp, L.R., et al:  Genetic Linkage Between Structural Loci for Albumin and Group Specific Component (Gc) , Amer J Hum Genet , (July) 1967;, pp 559-571.
Blumberg, B.S.; Kaarsalo, E.: and Melartin, L.:  Autosomal Linkage Between Albumin and Gc Loci , Clin Res 14:481 ( (Dec 13) ) 1966;.
Kaarsalo, E.; Melartin, L.; and Blumberg, B.S.:  Autosomal Linkage Between the Albumin and Gc Loci in Humans , Science , 158:123-125 ( (Oct 6) ) 1967;.
Hirschfeld, J.:  The Gc-system , Progr Allerg 6:155-186, 1962;.
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