0
ARTICLE |

Vincristine Sulfate in Management of Wilms' Tumor: Title and subTitle BreakReplacement of Preoperative Irradiation by Chemotherapy FREE

Margaret P. Sullivan, MD; Wataru W. Sutow, MD; Ayten Cangir, MD; Grant Taylor, MD
[+] Author Affiliations

Read in part at the 58th annual meeting of the American Association for Cancer Research, Chicago, April 14, 1967.

Reprint requests to 6723 Bertner Dr, Houston 77025 (Dr. Sullivan).


JAMA. 1967;202(5):381-384. doi:10.1001/jama.1967.03130180047006
Text Size: A A A
Published online

Four children with inoperable unilateral Wilms' tumor were given vincristine sulfate in lieu of preoperative irradiation therapy. Two to four doses of vincristine were given to each child. In each case, there was prompt and dramatic regression in all demonstrable tumor sites. The time from the beginning of chemotherapy to nephrectomy ranged from 12 to 21 days. After nephrectomy, weekly treatments of vincristine were continued for a total of 12 injections, and the abdominal tumor bed was irradiated. If pulmonary metastases were demonstrable, the entire thorax was also irradiated. At present, all four children are living without evidence of malignant disease, 5 to 21 months after vincristine therapy was begun.

REFERENCES

Sutow, W.W.; Thurman, W.G.; and Windmiller, J.:  Vincristine (Leurocristine) Sulfate in the Treatment of Children With Metastatic Wilms' Tumor , Pediatrics 32:880-887 ( (Nov) ) 1963;.
Sullivan, M.P.:  Curable Metastatic Tumors of Childhood , Texas J Med 61:800-805 ( (Nov) ) 1965;.
Sutow, W.W.:  Effective Chemotherapy in Children With Wilms' Tumor , Southern Med J 60:254-256 ( (March) ) 1967;.
 Evaluation of an Antineoplastic Agent, Dactinomycin (Cosmegen). COUNCIL ON DRUGS , JAMA 196:353-354 ( (April 25) ) 1966;.
Farber, S.:  Chemotherapy in the Treatment of Leukemia and Wilms' Tumor , JAMA 198:826-836 ( (Nov 21) ) 1966;.
Fernbach, D.J., and Martyn, D.T.:  Role of Dactinomycin in the Improved Survival of Children With Wilms' Tumor , JAMA 195:1005-1009 ( (March 2) ) 1966;.
Burgert, E.O., Jr., and Glidewell, O.:  Dactinomycin in Wilms' Tumor , JAMA 199:464-468 ( (Feb 13) ) 1967;.
Sutow, W.W., and Sullivan, M.P.:  Vincristine in Primary Treatment of Wilms' Tumor , Texas J Med 61:794-799 ( (Nov) ) 1965;.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Sutow, W.W.; Thurman, W.G.; and Windmiller, J.:  Vincristine (Leurocristine) Sulfate in the Treatment of Children With Metastatic Wilms' Tumor , Pediatrics 32:880-887 ( (Nov) ) 1963;.
Sullivan, M.P.:  Curable Metastatic Tumors of Childhood , Texas J Med 61:800-805 ( (Nov) ) 1965;.
Sutow, W.W.:  Effective Chemotherapy in Children With Wilms' Tumor , Southern Med J 60:254-256 ( (March) ) 1967;.
 Evaluation of an Antineoplastic Agent, Dactinomycin (Cosmegen). COUNCIL ON DRUGS , JAMA 196:353-354 ( (April 25) ) 1966;.
Farber, S.:  Chemotherapy in the Treatment of Leukemia and Wilms' Tumor , JAMA 198:826-836 ( (Nov 21) ) 1966;.
Fernbach, D.J., and Martyn, D.T.:  Role of Dactinomycin in the Improved Survival of Children With Wilms' Tumor , JAMA 195:1005-1009 ( (March 2) ) 1966;.
Burgert, E.O., Jr., and Glidewell, O.:  Dactinomycin in Wilms' Tumor , JAMA 199:464-468 ( (Feb 13) ) 1967;.
Sutow, W.W., and Sullivan, M.P.:  Vincristine in Primary Treatment of Wilms' Tumor , Texas J Med 61:794-799 ( (Nov) ) 1965;.
CME Course for:


You need to register in order to view this quiz.


To understand the clinical management of acute heart failure syndromes.
Accreditation Information The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
To view and print your certificate and access a summary of your CME courses go to My CME.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Response

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.