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Modified-Fat Dietary Management of the Young Male With Coronary Disease: Title and subTitle BreakA Five-Year Report FREE

Marvin L. Bierenbaum, MD; Donald P. Green, MD; Alvin Florin, MD; Alan I. Fleischman, PhD; Anne B. Caldwell, PhD
[+] Author Affiliations

Read in part before the Council on Arteriosclerosis at the 19th annual meeting of the American Heart Association, Oct 15, 1965, Miami Beach, Fla.

Reprint requests to 45 Elm St, Montclair, NJ 07042 (Dr. Bierenbaum).


JAMA. 1967;202(13):1119-1123. doi:10.1001/jama.1967.03130260041006
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One hundred young male outpatients with coronary disease who were under dietary management with a 28% fat diet were group-matched to a non-dietary-managed group in regard to age, age at infarction, number of infarctions, prevalence of hypertension, degree of angina, and value of serum cholesterol, among other factors. The diet-managed group experienced a significant reduction in serum cholesterol value, while the non-dietary-managed group did not. No significant differences were noted between the two groups in levels for serum total lipids, phospholipids, and triglycerides. Under the experimental conditions employed, the degree of unsaturation of the diet did not appear to influence serum cholesterol value or mortality. The non-dietary-managed group had a 160% higher recurrent infarction rate and a 233% higher mortality rate than did the dietary-managed group during the first five years of observation.

REFERENCES

Jolliffe, N.; Rinzler, S.H.; and Archer, M.:  The Anti-Coronary Club: Including a Discussion of the Effects of a Prudent Diet on Serum Cholesterol Level of Middle-Aged Men . Amer J Clin Nutr 7:451-462 ( (July) -Aug) 1959;.
Kinsell, L.W., et al:  Dietary Modification of Serum Cholesterol and Phospholipid Levels , J Clin Endocr 12:909-913 ( (July) ) 1952;.
Ahrens, E.H., et al:  Effects of Dietary Fats on Serum Lipids of Human Subjects , J Clin Invest 34:918 ( (June) ) 1955;.
Morrison, L.M.:  Diet in Coronary Atherosclerosis , JAMA 173:884-888 ( (June 25) ) 1960;.
Bierenbaum, M.L., et al:  Blood Cholesterol and Coronary Heart Disease , J Med Soc New Jersey 58:134-138 ( (April) ) 1961;.
Bierenbaum, M.L., et al:  The Effects of Two Low Fat Dietary Patterns on the Blood Cholesterol Level of Young Male Coronary Patients , J Chronic Dis 16:1073-1083 ( (Oct) ) 1963;.
Yacowitz, H.; Fleischman, A.I.; and Bierenbaum, M.L.:  Effects of Oral Calcium Upon Serum Lipids in Man , Brit Med J 5446:1352-1354 ( (May 22) ) 1965;.
Anderson, J.T., and Keys, A.:  Cholesterol in Serum and Lipoprotein Fractions , Clin Chem 2:145-159 ( (June) ) 1956;.
Abell, L.L., et al:  A Simplified Method for the Estimation of Total Cholesterol in Serum and Demonstration of Its Specificity , J Biol Chem 195:357-366 ( (March) ) 1952;.
Van Handel, E., and Zilversmit, D.B.:  Micromethod for the Direct Determination of Serum Triglycerides , J Lab Clin Med 50:152-157 ( (July) ) 1957;.
Bartlett, G.R.:  Phosphorous Assay in Column Chromatography , J Biol Chem 234:466-468 ( (March) ) 1959;.
Bierenbaum, M.L.; Gherman, C.; and Eastwood, G.:  Fat-Modified Frozen Food Dietary Pattern: Effect on Blood Cholesterol Levels of Young Men With Proved Myocardial Infarction , JAMA 182:296-298 ( (Oct 20) ) 1962;.
Bierenbaum, M.L.: The Effect of a Fat-Modified Frozen Food Dietary Pattern on the Blood Cholesterol Levels of Young Male Coronary Patients: A Three-Month Study, Memorias del IVth Congreso Mundial de Cardiologia 3-A 1963.
Fleischman, A.I.; Hayton, T.; and Bierenbaum, M.L.:  Objective Biochemical Determination of Dietary Adherence in the Young Coronary Male , Circulation 32( (suppl 2) ):12 (Oct) 1965;.
Fleischman, A.I.; Hayton, T.; and Bierenbaum, M.L.:  Variation in Composition of Serum Free Fatty Acids With Dietary Change Under Isocaloric Conditions , Amer J Clin Nutr 15:299-302 ( (Nov) ) 1964;.
Hirsch, J., et al:  Studies of Adipose Tissue in Man , Amer J Clin Nutr 8:499-511 ( (July) -Aug) 1960;.
Nomenclature and Criteria for Diagnosis of Diseases of the Heart and Blood Vessels , ed 6, New York: New York Heart Assoc, 1964;, p 112.
Stamler, J.:  The Problem of Elevated Blood Cholesterol , Amer J Public Health 3:14-19 ( (March) ) 1960;.
Erickson, B.A., et al:  The Effect of Partial Hydrogenation of Dietary Fats, of the Ratio of Polyunsaturated to Saturated Fatty Acids, and of Dietary Cholesterol Upon Plasma Lipids in Man , J Clin Invest 43:2017-2025 ( (Nov) ) 1964;.
Reiser, R.:  The Pros and Cons of the Efficacy of Polyunsaturated Fatty Acids to Reduce Serum Cholesterol Levels , J Amer Oil Chem Soc 43:112A ( (March) ) 1966;.
Fleischman, A.I.; Hayton. T.; and Bierenbaum, M.L.:  Relationships of Serum Lipids to Certain Dietary Factors in Young Males With Coronary Heart Disease , J Amer Diet Assoc 50:112-115 ( (Feb) ) 1967;.
Antonis, A., and Bersohn, I.:  The Influence of Diet on Serum Triglycerides in South Africa White and Bantu Prisoners , Lancet 1:3-9 ( (Jan 7) ) 1961;.
Little, J.A., et al:  Studies of Male Survivors of Myocardial Infarction-IV: Serum Lipids and Five-Year Survival , Circulation 31:854-862 ( (June) ) 1965;.
Gertler, M.M., et al:  Long-Term Follow-Up Study of Young Coronary Patients , Amer J Med Sci 247:145-155 ( (Feb) ) 1964;.
Christakis, G., et al:  The Anti-Coronary Club: A Dietary Approach to the Prevention of Coronary Heart Disease , Amer J Public Health 56:299-314 ( (Feb) ) 1966;.

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Jolliffe, N.; Rinzler, S.H.; and Archer, M.:  The Anti-Coronary Club: Including a Discussion of the Effects of a Prudent Diet on Serum Cholesterol Level of Middle-Aged Men . Amer J Clin Nutr 7:451-462 ( (July) -Aug) 1959;.
Kinsell, L.W., et al:  Dietary Modification of Serum Cholesterol and Phospholipid Levels , J Clin Endocr 12:909-913 ( (July) ) 1952;.
Ahrens, E.H., et al:  Effects of Dietary Fats on Serum Lipids of Human Subjects , J Clin Invest 34:918 ( (June) ) 1955;.
Morrison, L.M.:  Diet in Coronary Atherosclerosis , JAMA 173:884-888 ( (June 25) ) 1960;.
Bierenbaum, M.L., et al:  Blood Cholesterol and Coronary Heart Disease , J Med Soc New Jersey 58:134-138 ( (April) ) 1961;.
Bierenbaum, M.L., et al:  The Effects of Two Low Fat Dietary Patterns on the Blood Cholesterol Level of Young Male Coronary Patients , J Chronic Dis 16:1073-1083 ( (Oct) ) 1963;.
Yacowitz, H.; Fleischman, A.I.; and Bierenbaum, M.L.:  Effects of Oral Calcium Upon Serum Lipids in Man , Brit Med J 5446:1352-1354 ( (May 22) ) 1965;.
Anderson, J.T., and Keys, A.:  Cholesterol in Serum and Lipoprotein Fractions , Clin Chem 2:145-159 ( (June) ) 1956;.
Abell, L.L., et al:  A Simplified Method for the Estimation of Total Cholesterol in Serum and Demonstration of Its Specificity , J Biol Chem 195:357-366 ( (March) ) 1952;.
Van Handel, E., and Zilversmit, D.B.:  Micromethod for the Direct Determination of Serum Triglycerides , J Lab Clin Med 50:152-157 ( (July) ) 1957;.
Bartlett, G.R.:  Phosphorous Assay in Column Chromatography , J Biol Chem 234:466-468 ( (March) ) 1959;.
Bierenbaum, M.L.; Gherman, C.; and Eastwood, G.:  Fat-Modified Frozen Food Dietary Pattern: Effect on Blood Cholesterol Levels of Young Men With Proved Myocardial Infarction , JAMA 182:296-298 ( (Oct 20) ) 1962;.
Bierenbaum, M.L.: The Effect of a Fat-Modified Frozen Food Dietary Pattern on the Blood Cholesterol Levels of Young Male Coronary Patients: A Three-Month Study, Memorias del IVth Congreso Mundial de Cardiologia 3-A 1963.
Fleischman, A.I.; Hayton, T.; and Bierenbaum, M.L.:  Objective Biochemical Determination of Dietary Adherence in the Young Coronary Male , Circulation 32( (suppl 2) ):12 (Oct) 1965;.
Fleischman, A.I.; Hayton, T.; and Bierenbaum, M.L.:  Variation in Composition of Serum Free Fatty Acids With Dietary Change Under Isocaloric Conditions , Amer J Clin Nutr 15:299-302 ( (Nov) ) 1964;.
Hirsch, J., et al:  Studies of Adipose Tissue in Man , Amer J Clin Nutr 8:499-511 ( (July) -Aug) 1960;.
Nomenclature and Criteria for Diagnosis of Diseases of the Heart and Blood Vessels , ed 6, New York: New York Heart Assoc, 1964;, p 112.
Stamler, J.:  The Problem of Elevated Blood Cholesterol , Amer J Public Health 3:14-19 ( (March) ) 1960;.
Erickson, B.A., et al:  The Effect of Partial Hydrogenation of Dietary Fats, of the Ratio of Polyunsaturated to Saturated Fatty Acids, and of Dietary Cholesterol Upon Plasma Lipids in Man , J Clin Invest 43:2017-2025 ( (Nov) ) 1964;.
Reiser, R.:  The Pros and Cons of the Efficacy of Polyunsaturated Fatty Acids to Reduce Serum Cholesterol Levels , J Amer Oil Chem Soc 43:112A ( (March) ) 1966;.
Fleischman, A.I.; Hayton. T.; and Bierenbaum, M.L.:  Relationships of Serum Lipids to Certain Dietary Factors in Young Males With Coronary Heart Disease , J Amer Diet Assoc 50:112-115 ( (Feb) ) 1967;.
Antonis, A., and Bersohn, I.:  The Influence of Diet on Serum Triglycerides in South Africa White and Bantu Prisoners , Lancet 1:3-9 ( (Jan 7) ) 1961;.
Little, J.A., et al:  Studies of Male Survivors of Myocardial Infarction-IV: Serum Lipids and Five-Year Survival , Circulation 31:854-862 ( (June) ) 1965;.
Gertler, M.M., et al:  Long-Term Follow-Up Study of Young Coronary Patients , Amer J Med Sci 247:145-155 ( (Feb) ) 1964;.
Christakis, G., et al:  The Anti-Coronary Club: A Dietary Approach to the Prevention of Coronary Heart Disease , Amer J Public Health 56:299-314 ( (Feb) ) 1966;.
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