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Intravenous Administration of Furosemide in Heart Failure FREE

Michael Davidov, MD; Nikos Kakaviatos, MD; Frank A. Finnerty, Jr., MD
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JAMA. 1967;200(10):824-829. doi:10.1001/jama.1967.03120230076009
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Furosemide was administered intravenously to 41 patients with edema who had become refractory to both thiazides and organomercurials. Repeated doses of 80 to 160 mg completely cleared peripheral edema in all patients and pulmonary congestion (roentgenographically demonstrated) in nine of 12 patients by the fifth day. Fifteen minutes after the injection, there was a 13-fold increase in urinary output and more than a fourfold increase in urinary sodium excretion. The urinary sodiumpotassium excretion ratio during furosemide-induced diuresis was increased more than onefold. Potassium excretion was not increased unless excessive diuresis occurred.

REFERENCES

Berry, J.W.; Chappell, D.C.; and Barnes, R.B.:  Improved Method of Flame Photometry , Industr Engineering Chem Anal 18:19-22 ( (March) ) 1946;.
London, M., and Marymont, J.H., Jr.:  Analyses on Heat-Coagulated Blood and Serum: I. The Determination of Uric Acid , Clin Chem 10:298-301 ( (April) ) 1964;.
Somogyi, M.:  Notes on Sugar Determination , J Biol Chem 195:19-23 ( (July) ) 1952;.
Klein, B., Read, P.A.; and Babson, A.L.:  The Determination of Alkaline Phosphatase , Clin Chem 6:269-275 ( (June) ) 1960;.
Babson, A.L., et al:  Use of a New Assay in the Study of Serum Alkaline Phosphate Levels in 2,000 Hospital Patients , Clin Chem 6:495-500 ( (Oct) ) 1960;.
Furano, A., and Sheena, A.:  Adaptation of Babson's Method for the Determination of SGOT in Clinical Laboratory , Clin Chem 11:23-28 ( (Jan) ) 1965;.
Welchselbaum, F.:  Determination of Protein by Biuret Method , Amer J Clin Path 10:40-49 ( (June) ) 1946;.
Lillienfield, L., and Kovach, R.:  Simplified Method of Calculating Flow, Mean Circulation Time and Downslope From Indicator-Dilution Curves , Proc Soc Exp Biol Med 91:595-598 ( (April) ) 1956;.
Gabe, I., and Shillingford, J.:  The Photo-Electric Earpiece Technique for Recording Dye Dilution Curves , Brit Heart J 13: 271-280 ( (May) ) 1961;.
Davidov, M.; Kakaviatos, N.; and Finnerty, F.A., Jr.:  Diuretic and Antihypertensive Properties of Furosemide , J New Drugs 6:123-124 ( (March) -April) 1966;.
Muth, R.G.:  Furosemide Diuresis in Renal Insufficiency , read before the Third International Congress of Nephrology, Washington, DC, Sept 25, 1966 .
Davidov, M.; Kakaviatos, N.; and Finnerty, F.A., Jr.:  The Antihypertensive Properties of I.V. Furosemide , Circulation to be published.
Muth, R.G.:  Diuretic Response to Furosemide in the Presence of Renal Insufficiency , JAMA 195:1066-1069 ( (March 21) ) 1966;.
Berman, L.B., and Ebrahimi, A.:  Experiences With Furosemide in Renal Disease , Proc Soc Exp Biol Med 25:333-336 ( (Feb) ) 1965;.
Hook, J.B., and Williamson, H.E.:  Addition of the Saluretic Action of Furosemide to the Saluretic Action of Certain Other Agents , J Pharmacol Exp Ther 148:88-93 ( (April) ) 1965;.
Hook, J.B., and Williamson, H.E.:  Influence of Probenecid and Alterations in Acid-Base Balance of Saluretic Activity of Furosemide , J Pharmacol Exp Ther 149:404-408 ( (May) ) 1965;.
Suki, W.; Rector, F.; and Seldin, D.:  The Site of Action of Furosemide and Other Diuretics in the Dog , J Clin Invest 44: 1458-1469 ( (Sept) ) 1965;.
Morrin, P.A.:  The Effect of Furosemide, a New Diuretic Agent, on Renal Concentrating and Diluting Mechanism , Canad J Physiol Pharmacol 44:129-137 ( (July) ) 1966;.
Ogden, D.A., et al:  A Comparison of the Properties of Chlorothiazide, Spironolactone, and Combination of Both as Diuretic Agents , New Eng J Med 265:358-361 ( (Aug) ) 1961;.

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Berry, J.W.; Chappell, D.C.; and Barnes, R.B.:  Improved Method of Flame Photometry , Industr Engineering Chem Anal 18:19-22 ( (March) ) 1946;.
London, M., and Marymont, J.H., Jr.:  Analyses on Heat-Coagulated Blood and Serum: I. The Determination of Uric Acid , Clin Chem 10:298-301 ( (April) ) 1964;.
Somogyi, M.:  Notes on Sugar Determination , J Biol Chem 195:19-23 ( (July) ) 1952;.
Klein, B., Read, P.A.; and Babson, A.L.:  The Determination of Alkaline Phosphatase , Clin Chem 6:269-275 ( (June) ) 1960;.
Babson, A.L., et al:  Use of a New Assay in the Study of Serum Alkaline Phosphate Levels in 2,000 Hospital Patients , Clin Chem 6:495-500 ( (Oct) ) 1960;.
Furano, A., and Sheena, A.:  Adaptation of Babson's Method for the Determination of SGOT in Clinical Laboratory , Clin Chem 11:23-28 ( (Jan) ) 1965;.
Welchselbaum, F.:  Determination of Protein by Biuret Method , Amer J Clin Path 10:40-49 ( (June) ) 1946;.
Lillienfield, L., and Kovach, R.:  Simplified Method of Calculating Flow, Mean Circulation Time and Downslope From Indicator-Dilution Curves , Proc Soc Exp Biol Med 91:595-598 ( (April) ) 1956;.
Gabe, I., and Shillingford, J.:  The Photo-Electric Earpiece Technique for Recording Dye Dilution Curves , Brit Heart J 13: 271-280 ( (May) ) 1961;.
Davidov, M.; Kakaviatos, N.; and Finnerty, F.A., Jr.:  Diuretic and Antihypertensive Properties of Furosemide , J New Drugs 6:123-124 ( (March) -April) 1966;.
Muth, R.G.:  Furosemide Diuresis in Renal Insufficiency , read before the Third International Congress of Nephrology, Washington, DC, Sept 25, 1966 .
Davidov, M.; Kakaviatos, N.; and Finnerty, F.A., Jr.:  The Antihypertensive Properties of I.V. Furosemide , Circulation to be published.
Muth, R.G.:  Diuretic Response to Furosemide in the Presence of Renal Insufficiency , JAMA 195:1066-1069 ( (March 21) ) 1966;.
Berman, L.B., and Ebrahimi, A.:  Experiences With Furosemide in Renal Disease , Proc Soc Exp Biol Med 25:333-336 ( (Feb) ) 1965;.
Hook, J.B., and Williamson, H.E.:  Addition of the Saluretic Action of Furosemide to the Saluretic Action of Certain Other Agents , J Pharmacol Exp Ther 148:88-93 ( (April) ) 1965;.
Hook, J.B., and Williamson, H.E.:  Influence of Probenecid and Alterations in Acid-Base Balance of Saluretic Activity of Furosemide , J Pharmacol Exp Ther 149:404-408 ( (May) ) 1965;.
Suki, W.; Rector, F.; and Seldin, D.:  The Site of Action of Furosemide and Other Diuretics in the Dog , J Clin Invest 44: 1458-1469 ( (Sept) ) 1965;.
Morrin, P.A.:  The Effect of Furosemide, a New Diuretic Agent, on Renal Concentrating and Diluting Mechanism , Canad J Physiol Pharmacol 44:129-137 ( (July) ) 1966;.
Ogden, D.A., et al:  A Comparison of the Properties of Chlorothiazide, Spironolactone, and Combination of Both as Diuretic Agents , New Eng J Med 265:358-361 ( (Aug) ) 1961;.
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