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ISN'T IT A SHAM? FREE

JAMA. 1966;198(6):660-660. doi:10.1001/jama.1966.03110190142040
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Physicians are justifiably perplexed when confronted with recently publicized legal and technical complexities of clinical investigation. In the realm of the ethical implications of research, this is the decade of doubt. The problem has apparently been resolved in a novel fashion by investigators whose motto is "almost but not quite." In their hands therapeutic agents are always on the verge of being administered, but the patient somehow escapes at the last moment. Note, for example, the study concerned with the fall in plasma content of free fatty acids associated with the sight of food.1 Succulent rare roast beef was placed before eager subjects who were required to look at but not permitted to taste this appetizing morsel. The investigator need have no fear of possible food allergy in these instances! Or consider the recent investigation of the effect of sham smoking upon serum lipids.2 Subjects were asked to

REFERENCES

Penick, S.B.; Prince, H.; and Hinkle, Jr., L.E.:  Fall in Plasma Content of Free Fatty Acids Associated With Sight of Food , New Eng J Med 275:416-419 ( (Aug 25) ) 1966;.
Murchison, L.E., and Fyfe, T.:  Effects of Cigarette Smoking on Serum-Lipids, Blood-Glucose, and Platelet Adhesiveness , Lancet 2:182-184 ( (July 23) ) 1966;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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Penick, S.B.; Prince, H.; and Hinkle, Jr., L.E.:  Fall in Plasma Content of Free Fatty Acids Associated With Sight of Food , New Eng J Med 275:416-419 ( (Aug 25) ) 1966;.
Murchison, L.E., and Fyfe, T.:  Effects of Cigarette Smoking on Serum-Lipids, Blood-Glucose, and Platelet Adhesiveness , Lancet 2:182-184 ( (July 23) ) 1966;.
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To understand the clinical management of acute heart failure syndromes.
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