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Effect of the Anti-Coronary Club Program on Coronary Heart Disease Risk-Factor Status FREE

George Christakis, MD; Seymour H. Rinzler, MD; Morton Archer, MBA, MPH; Arthur Kraus, ScD
[+] Author Affiliations

Reprint requests to Room 714, 93 Worth St, New York 10013 (Mr. Archer).


From the Bureau of Nutrition and the Office of Research, New York City Department of Health.


JAMA. 1966;198(6):597-604. doi:10.1001/jama.1966.03110190079022
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A group of 814 men at large, 40 to 59 years old, have been placed in a diet relatively rich in polyunsaturated fatty acids. The study diet has significantly lowered the serum cholesterol levels and maintained these lower levels for periods as long as five years. The study protocol has also been effective in significantly reducing the incidence of obesity and hypertension during the first four years of study participation. Among a control group of 463 men of similar age, the prevalence of these conditions was stable. After the men had participated in the study for four years, the differences between the experimental and control groups in prevelance of these risk factors (obesity, hypertension, and hypercholesterolemia) were statistically significant. Accompanying these significant differences, a statistically significant difference was observed between the two groups in morbidity from new coronary heart disease.

REFERENCES

Jolliffe, N.; Rinzler, S.H.; and Archer, M.:  The Anti-Coronary Club: Including a Discussion of the Effects of a Prudent Diet on the Serum Cholesterol Levels of Middle-Aged Men , Amer J Clin Nutr 7:451-462 ( (July) -Aug) 1959;.
Jolliffe, N.; Rinzler, S.H.; and Archer, M.:  Effect on Serum Cholesterol of a Prudent-type Reducing Diet: Study of 111 Obese Men 50 to 59 Years Old , Arch Intern Med 109:566-572 ( (May) ) 1962;.
Rinzler, S.H., et al:  The Anti-Coronary Club: The Effect of Diet on the Control of Serum Cholesterol , Health News 38:13-19 ( (Jan) ) 1961;.
Christakis, G., et al:  Effect of a Cholesterol-Lowering Diet on Fatty Acid Composition of Subcutaneous Fat in Man , abstracted, Circulation 26:649 ( (Oct) ) 1962;.
Christakis, G.J., et al:  Effect of a Cholesterol-Lowering Diet on the Serum Cholesterol, Serum Triglycerides, Serum Vitamin A and E Levels, and Fatty Acid Composition of Subcutaneous Fat in Man , abstracted, Circulation 28:703 ( (Oct) ) 1963;.
Jolliffe, N., et al:  The Anti-Coronary Club: The First Four Four Years , New York J Med 63:69-79 ( (Jan) ) 1963;.
Christakis, G., et al:  The Anti-Coronary Club: A Dietary Approach to The Prevention of Coronary Heart Disease—A Seven Year Report , Amer J Pub Health 56:299-314 ( (Feb) ) 1966;.
Dawber, T.R., et al:  Some Factors Associated With the Development of Coronary Heart Disease: Six Years' Follow-up Experience in the Framingham Study , Amer J Public Health 49:1349-1356 ( (Oct) ) 1959;.
 Evaluation of Serum Lipoprotein and Cholesterol Measurements as Predictors of Clinical Complications of Atherosclerosis , Circulation 14:691-742 ( (Oct) ) 1956;.
Nomenclature and Criteria for Diagnosis of Disease of the Heart and Blood Vessels , ed 5, Criteria Committee, New York Heart Association, 1955;.
Anderson, J.T., and Keys, A.:  Cholesterol in Serum and Lipoprotein Fractions: Its Measurement and Stability , Clin Chem 2:145, 1956;.
Abell, L.L., et al:  Simplified Method for Estimation of Total Cholesterol in Serum and Demonstration of Its Specificity , J Biol Chem 195:357, 1952;.
Kannel, W.B., et al:  Factors of Risk in the Development of Coronary Heart Disease: Six Year Follow-up Experience , Ann Intern Med 55:33-50 ( (July) ) 1961;.
Doyle, J., et al:  A Prospective Study of Degenerative Cardiovascular Disease in Albany: Report of Three Years Experience , Amer J Public Health 47 ( (suppl) pt II) 25-32: (April) 1957;.
Dahl, L.K.; Heine, M.; and Tessinari, L.:  Effects of Chronic Excess Salt Ingestion , J Exp Med 118:605-617 ( (Oct) ) 1963;.
Johnson, B.C., and Remington, R.D.:  A Sampling of Blood Pressure Levels in White and Negro Residents of Nassau, Bahamas , J Chron Dis 13:39-51 ( (Jan) ) 1961;.
 Diet and the Possible Prevention of Coronary Atheroma: A Council Statement Coucil on Foods and Nutrition , JAMA 194:1149-1150 ( (Dec 6) ) 1965;.
 Dietary Fat and Its Relation to Heart Attack and Strokes, Central Committee for Community and Medical Program, American Heart Association , Circulation 23:133-136 ( (Jan) ) 1961;.

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Jolliffe, N.; Rinzler, S.H.; and Archer, M.:  The Anti-Coronary Club: Including a Discussion of the Effects of a Prudent Diet on the Serum Cholesterol Levels of Middle-Aged Men , Amer J Clin Nutr 7:451-462 ( (July) -Aug) 1959;.
Jolliffe, N.; Rinzler, S.H.; and Archer, M.:  Effect on Serum Cholesterol of a Prudent-type Reducing Diet: Study of 111 Obese Men 50 to 59 Years Old , Arch Intern Med 109:566-572 ( (May) ) 1962;.
Rinzler, S.H., et al:  The Anti-Coronary Club: The Effect of Diet on the Control of Serum Cholesterol , Health News 38:13-19 ( (Jan) ) 1961;.
Christakis, G., et al:  Effect of a Cholesterol-Lowering Diet on Fatty Acid Composition of Subcutaneous Fat in Man , abstracted, Circulation 26:649 ( (Oct) ) 1962;.
Christakis, G.J., et al:  Effect of a Cholesterol-Lowering Diet on the Serum Cholesterol, Serum Triglycerides, Serum Vitamin A and E Levels, and Fatty Acid Composition of Subcutaneous Fat in Man , abstracted, Circulation 28:703 ( (Oct) ) 1963;.
Jolliffe, N., et al:  The Anti-Coronary Club: The First Four Four Years , New York J Med 63:69-79 ( (Jan) ) 1963;.
Christakis, G., et al:  The Anti-Coronary Club: A Dietary Approach to The Prevention of Coronary Heart Disease—A Seven Year Report , Amer J Pub Health 56:299-314 ( (Feb) ) 1966;.
Dawber, T.R., et al:  Some Factors Associated With the Development of Coronary Heart Disease: Six Years' Follow-up Experience in the Framingham Study , Amer J Public Health 49:1349-1356 ( (Oct) ) 1959;.
 Evaluation of Serum Lipoprotein and Cholesterol Measurements as Predictors of Clinical Complications of Atherosclerosis , Circulation 14:691-742 ( (Oct) ) 1956;.
Nomenclature and Criteria for Diagnosis of Disease of the Heart and Blood Vessels , ed 5, Criteria Committee, New York Heart Association, 1955;.
Anderson, J.T., and Keys, A.:  Cholesterol in Serum and Lipoprotein Fractions: Its Measurement and Stability , Clin Chem 2:145, 1956;.
Abell, L.L., et al:  Simplified Method for Estimation of Total Cholesterol in Serum and Demonstration of Its Specificity , J Biol Chem 195:357, 1952;.
Kannel, W.B., et al:  Factors of Risk in the Development of Coronary Heart Disease: Six Year Follow-up Experience , Ann Intern Med 55:33-50 ( (July) ) 1961;.
Doyle, J., et al:  A Prospective Study of Degenerative Cardiovascular Disease in Albany: Report of Three Years Experience , Amer J Public Health 47 ( (suppl) pt II) 25-32: (April) 1957;.
Dahl, L.K.; Heine, M.; and Tessinari, L.:  Effects of Chronic Excess Salt Ingestion , J Exp Med 118:605-617 ( (Oct) ) 1963;.
Johnson, B.C., and Remington, R.D.:  A Sampling of Blood Pressure Levels in White and Negro Residents of Nassau, Bahamas , J Chron Dis 13:39-51 ( (Jan) ) 1961;.
 Diet and the Possible Prevention of Coronary Atheroma: A Council Statement Coucil on Foods and Nutrition , JAMA 194:1149-1150 ( (Dec 6) ) 1965;.
 Dietary Fat and Its Relation to Heart Attack and Strokes, Central Committee for Community and Medical Program, American Heart Association , Circulation 23:133-136 ( (Jan) ) 1961;.
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