0
ARTICLE |

Measles Vaccine Field Trials in Alaska: Title and subTitle BreakIII. Two-Year Follow-up of Inactivated Vaccine Followed by Live, Attenuated Vaccine and of Immune Globulin With Live, Attenuated Vaccine FREE

Jacob A. Brody, MD; E. Russell Alexander, MD; Mary Lou Hanson, RN
[+] Author Affiliations

Parts I and II appeared in the issues of Aug 3 and Dec 14, 1965, respectively.

Reprint requests to 7550 Wisconsin Ave, Bethesda, Md 20014 (Dr. Brody).


From the Epidemiology Section (Dr. Brody) and the Field Unit (Mrs. Hanson) of the Arctic Health Research Center, US Public Health Service, Anchorage, Alaska, and the Department of Preventive Medicine, University of Washington School of Medicine, Seattle (Dr. Alexander). Dr. Brody is now with the Epidemiology Branch, National Institute of Neurological Diseases and Blindness, Bethesda, Md. Dr. Alexander is Markle Scholar in Medical Science.


JAMA. 1966;196(9):757-760. doi:10.1001/jama.1966.03100220049015
Text Size: A A A
Published online

Measles vaccine field trials in remote Alaskan Eskimo communities were followed up after two years. In one village, administration of inactivated measles virus vaccine had been followed in five to seven weeks by live, attenuated measles virus vaccine. In the second village, live vaccine had been given with measles immune globulin. Natural measles appeared in both villages after vaccination. Following exposure to natural measles, antibody rises were noted primarily among subjects with low titers. Titer rise was more frequent among those who received inactivated vaccine plus live vaccine. Two years after vaccination, and in spite of the booster effect of natural measles, titers among those who received inactivated vaccine plus live vaccine had fallen to low or undetectable levels in more than half of the recipients (51 of 85), suggesting that this combination may not produce lasting protection. Geometric mean titers were highest after natural measles, intermediate after live vaccine plus immune globulin, and lowest after inactivated vaccine plus live vaccine.

REFERENCES

Brody, J.A., et al:  Measles Vaccine Field Trials in Alaska: I. Killed Vaccine Followed by Live Attenuated Vaccine and Gamma Globulin With Live Attenuated Vaccine , JAMA 189:339-342 ( (Aug 3) ) 1964;.
Brody, J.A., et al:  Rubella Epidemic on St. Paul Island in the Pribilofs, 1963: I. Epidemiologic, Clinical, and Serologic Findmgs , JAMA 191:619-623 ( (Feb 22) ) 1965;.
Brody, J.A., et al:  Prevention of Rubella by Gamma Globulin During an Epidemic in Barrow, Alaska, in 1964 , New Eng J Med 272:127-129 ( (Jan 21) ) 1965;.
Rosen, L.:  Hemagglutination and Hemagglutination-Inhibition With Measles Virus , Virology 13:139-141 ( (Jan) ) 1961;.
Black, F.L., and Rosen, L.:  Patterns of Measles Antibodies in Residents of Tahiti and Their Stability in the Absence of Reexposure , J Immunol 88:725-731 ( (June) ) 1962;.
Krugman, S., et al:  Studies on Immunity to Measles , J Pediatrics 66:471-488 ( (March) ) 1965;.
Rauh, L.W., and Schmidt, R.:  Measles Immunization With Killed Virus Vaccine , Amer J Dis Child 109:232-237 ( (March) ) 1965;.
Norrby, E.,  Hemagglutination by Measles Virus: 4. A Simple Procedure for Production of High Potency Antigen for Hemagglutination-Inhibition (HI) Tests , Proc Soc Exp Biol Med 111:814 ( (Dec) ) 1962;.
Schluederberg, A., and Karelitz, S.:  Suppression of Measles 19S Antibody Formation as Evidence of Immunity , JAMA 191:1064-1066 ( (March 29) ) 1965;.
Finkelstein, M.S., and Uhr, J.W.:  Specific Inhibition of Antibody Formation by Passively Administered 19S and 7S Antibody , Science 146:67-69 ( (Oct 2) ) 1964;.

First Page Preview

First page PDF preview

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Brody, J.A., et al:  Measles Vaccine Field Trials in Alaska: I. Killed Vaccine Followed by Live Attenuated Vaccine and Gamma Globulin With Live Attenuated Vaccine , JAMA 189:339-342 ( (Aug 3) ) 1964;.
Brody, J.A., et al:  Rubella Epidemic on St. Paul Island in the Pribilofs, 1963: I. Epidemiologic, Clinical, and Serologic Findmgs , JAMA 191:619-623 ( (Feb 22) ) 1965;.
Brody, J.A., et al:  Prevention of Rubella by Gamma Globulin During an Epidemic in Barrow, Alaska, in 1964 , New Eng J Med 272:127-129 ( (Jan 21) ) 1965;.
Rosen, L.:  Hemagglutination and Hemagglutination-Inhibition With Measles Virus , Virology 13:139-141 ( (Jan) ) 1961;.
Black, F.L., and Rosen, L.:  Patterns of Measles Antibodies in Residents of Tahiti and Their Stability in the Absence of Reexposure , J Immunol 88:725-731 ( (June) ) 1962;.
Krugman, S., et al:  Studies on Immunity to Measles , J Pediatrics 66:471-488 ( (March) ) 1965;.
Rauh, L.W., and Schmidt, R.:  Measles Immunization With Killed Virus Vaccine , Amer J Dis Child 109:232-237 ( (March) ) 1965;.
Norrby, E.,  Hemagglutination by Measles Virus: 4. A Simple Procedure for Production of High Potency Antigen for Hemagglutination-Inhibition (HI) Tests , Proc Soc Exp Biol Med 111:814 ( (Dec) ) 1962;.
Schluederberg, A., and Karelitz, S.:  Suppression of Measles 19S Antibody Formation as Evidence of Immunity , JAMA 191:1064-1066 ( (March 29) ) 1965;.
Finkelstein, M.S., and Uhr, J.W.:  Specific Inhibition of Antibody Formation by Passively Administered 19S and 7S Antibody , Science 146:67-69 ( (Oct 2) ) 1964;.
CME Course for:


You need to register in order to view this quiz.


To understand the clinical management of acute heart failure syndromes.
Accreditation Information The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
To view and print your certificate and access a summary of your CME courses go to My CME.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Response

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.