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Pulmonary Clearance of Radio-Iodinated Serum Albumin I 131 FREE

José Ramírez-R., MD; E. Ulric Buddemeyer
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From the Medical Service (Dr. Ramirez-R.) and Biochemistry Research Laboratory (Mr. Buddemeyer) Veterans Administration Hospital and the departments of medicine, University of Maryland School of Medicine and the Johns Hopkins University School of Medicine (Dr. Ramirez-R.) Baltimore.


JAMA. 1965;193(7):595-595. doi:10.1001/jama.1965.03090070045014
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Marked delay in the clearance of radio-iodinated serum albumin I131 (Risa) when administered intravenously was recently observed in one patient with alveolar proteinosis and in another with uremic pneumonitis.1 In the same study, a moderate delay in the rate of pulmonary clearance of intravenous radio-iodinated serum albumin was noted in subjects in congestive heart failure. Since this technique for measuring pulmonary clearance could have wide applicability, an exploration of its diagnostic and prognostic potentialities was undertaken. This paper presents the negative results of this exploration in tuberculosis, alveolar proteinosis, and other pulmonary disorders.

Material and Methods.—  The right lung of 28 subjects was studied. Their diagnoses, as established bacteriologically or histologically, are listed in Table 1. Six of the 18 patients with tuberculosis had no involvement of the right lung and these uninvolved lungs and the right lungs of two normal subjects were used as "control lungs." The

REFERENCES

Henkin, R.I., and Bishop, H.A.:  Pulmonary Clearance of Radioactive Iodinated Serum Albumin in Man , J Lab Clin Med 60:709-713 ( (Nov) ) 1962;.
Weissler, A.M.; McGraw, B.H.; and Warren, J.V.:  Pulmonary Blood Volume Determined by Radioactive Tracer Technique , J Appl Physiol 14:531-534 ( (July) ) 1959;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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Henkin, R.I., and Bishop, H.A.:  Pulmonary Clearance of Radioactive Iodinated Serum Albumin in Man , J Lab Clin Med 60:709-713 ( (Nov) ) 1962;.
Weissler, A.M.; McGraw, B.H.; and Warren, J.V.:  Pulmonary Blood Volume Determined by Radioactive Tracer Technique , J Appl Physiol 14:531-534 ( (July) ) 1959;.
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