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Pentazocine— A New Nonaddicting Analgesic: Title and subTitle BreakA Double-Blind Evaluation in Postoperative Pain FREE

Max S. Sadove, MD; Reuben C. Balagot, MD
[+] Author Affiliations

Reprint requests to 840 S Wood St, Chicago 60612 (Dr. Sadove).


From the Division of Anesthesiology, Department of Surgery, Veterans Administration Hospital, Hines, Ill (Dr. Sadove), and the Division of Anesthesiology, Department of Surgery, University of Illinois, College of Medicine, Chicago (Dr. Balagot).


JAMA. 1965;193(11):887-892. doi:10.1001/jama.1965.03090110025006
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A double-blind study comparing single intramuscular doses of pentazocine, 30 mg, and meperidine hydrochloride, 50 or 100 mg, in a total of 219 postoperative male patients revealed no significant difference between the degree and duration of analgesia following administration of pentazocine and either 50 mg or 100 mg of meperidine hydrochloride. A slightly greater percentage of patients experienced pain relief after 100-mg doses of meperidine hydrochloride. Pentazocine is revealed as a clinically useful analgesic for postoperative pain, with side effects neither more numerous nor serious than those of meperidine hydrochloride at comparable analgesic doses. Both drugs produce moderate reduction of respiratory rates, compensatory increases in tidal volume, and no important changes in minute volume. The sedative effect of pentazocine is apparently less than that of meperidine hydrochloride.

REFERENCES

Keats, A.S., and Telford, J.:  Studies of Analgesic Drugs: VIII. Narcotic Antagonist Without Psychotomimetic Effects , J Pharmacol Exp Ther 143:157-164 ( (Feb) ) 1964;.
Archer, S., et al:  Narcotic Antagonists as Analgesics , Science 137:541-543 ( (Aug 17) ) 1962;.
Cass, L.S.; Frederik, W.S.; and Teodoro, J.V.:  Pentazocine as Analgesic: Clinical Evaluation , JAMA 188:112-115 ( (April 13) ) 1964;.
Mitchell, M.T.:  Evaluation of New Non-narcotic Analgesic in Obstetrics , Minnesota Med 46:1230-1234 ( (Dec) ) 1963;.
Sadove, M.; Balagot, R.C.; and Pecora, F.N.:  Pentazocine— New Nonaddicting Analgesic: Preliminary Single-Blind Study , JAMA 189:199-202 ( (July 20) ) 1964;.
Fraser, H.F., and Rosenberg, D.E.:  Studies on Human Addiction Liability of 2′Hydroxy-5F9-Dimethyl-2-(3,3-Dimethylallyl)-6,7-Benzomorphan (Win 20,228): Weak Narcotic Antagonist , J Pharmacol Exp Ther 143:149-156 ( (Feb) ) 1964;.

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Keats, A.S., and Telford, J.:  Studies of Analgesic Drugs: VIII. Narcotic Antagonist Without Psychotomimetic Effects , J Pharmacol Exp Ther 143:157-164 ( (Feb) ) 1964;.
Archer, S., et al:  Narcotic Antagonists as Analgesics , Science 137:541-543 ( (Aug 17) ) 1962;.
Cass, L.S.; Frederik, W.S.; and Teodoro, J.V.:  Pentazocine as Analgesic: Clinical Evaluation , JAMA 188:112-115 ( (April 13) ) 1964;.
Mitchell, M.T.:  Evaluation of New Non-narcotic Analgesic in Obstetrics , Minnesota Med 46:1230-1234 ( (Dec) ) 1963;.
Sadove, M.; Balagot, R.C.; and Pecora, F.N.:  Pentazocine— New Nonaddicting Analgesic: Preliminary Single-Blind Study , JAMA 189:199-202 ( (July 20) ) 1964;.
Fraser, H.F., and Rosenberg, D.E.:  Studies on Human Addiction Liability of 2′Hydroxy-5F9-Dimethyl-2-(3,3-Dimethylallyl)-6,7-Benzomorphan (Win 20,228): Weak Narcotic Antagonist , J Pharmacol Exp Ther 143:149-156 ( (Feb) ) 1964;.
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