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ARTICLE |

Measurement of Renal Plasma Flow by Iodopyracet I 131 FREE

Charles M. Elwood, MD; Joseph Armenia, MD; Dean Orman, MD; Arthur Morris, MD; Eugene M. Sigman, MD
[+] Author Affiliations

Reprint requests to 100 High St, Buffalo 14203 (Dr. Elwood).


From the departments of medicine and urology, School of Medicine of the State University of New York at Buffalo, and the Buffalo General Hospital.


JAMA. 1965;193(10):771-774. doi:10.1001/jama.1965.03090100017004
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Simultaneous renal clearances of para-aminohippuric acid (PAH) and tracer doses of iodopyracet I 131 with added nonradioactive iodopyracet were performed in 20 patients by the continuous infusion technique. The mean iodopyracet I 131 PAH clearance ratio was 1.02. Sequential clearance studies suggested minimal competitive inhibition for renal excretion between PAH and iodopyracet I 131.

REFERENCES

Cotlove, E.:  C14 Inulin Method, Carboxyl-Labeled Inulin as a Tracer for Inulin , Fed Proc 14:32, 1955;.
Concannon, J.P., et al:  I125 Allyl Inulin for the Determination of Glomerular Filtration Rate , Amer J Roentgen 92:302-308 ( (Aug) ) 1964;.
Tauxe, W.M., et al:  Renal Clearances , Proc Mayo Clin 39: 761-766 ( (Oct) ) 1964;.
Sigman, E.M., et al:  The Renal Clearance of I131-Labeled Sodium Iothalamate in Man , Invest Urol 2:432-438 ( (March) ) 1965;.
Morris, A.M., et al:  The Renal Clearance of I131-Labeled Meglumine Diatrizoate (Renografin) , J Nucl Med 6:183-192 ( (March) ) 1965;.
Smith, H.W., et al:  The Renal Clearances of Substituted Hippuric Acid Derivatives and Other Aromatic Acids in Dog and Man , J Clin Invest 24:388-404 ( (Sept) ) 1945;.
Schlegel, J.U.; Smith, B.G.; and O'Dell, R.M.:  Estimation of Effective Renal Plasma Flow Using I131-Labeled Hippuran , J Appl Physiol 17:80-82 ( (Jan) ) 1962;.
Schwartz, F.D., and Madeloff, M.S.:  Simultaneous Renal Clearances of Radio-Hippuran and PAH in Man . Clin Res 9:208, 1961;.
Bergström, J.; Bucht, H.; and Josephson, B.:  Determination of the Renal Blood Flow in Man by Means of Radioactive Diodrast and Renal Vein Catheterization , Scand J Clin Lab Invest 11:71-81 ( (Jan) ) 1959;.
Smith, H.W.; Goldring, W.; and Chasis, H.:  The Measurement of the Tubular Excretory Mass, Effective Blood Flow, and Filtration Rate in the Normal Human Kidney , J Clin Invest 17:263-278 ( (Feb) ) 1938;.
Block, J.B., and Burrows, B.A.:  Influence of Serum Protein Binding on Renal Clearance of I131-Labeled Diodrast , J Lab Clin Med 56:463-472 ( (Sept) ) 1960;.
Josephson, B., et al:  The Competition Between P-Amino-Hippuric Acid (PAH) and Diodrast for Renal Excretion and Extraction in Man , J Clin Invest 32:1184-1191 ( (Nov) ) 1953;.
Chasis, H., et al:  The Use of Sodium P-Aminohippurate for the Functional Evaluation of the Human Kidney , J Clin Invest 24:583-588 ( (Sept) ) 1945;.
Schlungbaum, W., and Billion, H.:  Die Bestimmung der Effektiven Plasma-Nierendurchströmung mit Radioaktivem, mit I131 Markiertem Perabrodil-M , Sonderbände zur Strahlentherapie 36:145-150 ( (March) ) 1956;.
Parker, R.H., and Beierwaltes, W.H.:  I131 Diodrast for the Determination of Renal Clearance and Renal Tubular Mass , J Nucl Med 1:41-49 ( (Jan) ) 1960;.
Fozzard, H.A.:  Diodrast (I131) Whole Blood Clearance as an Index of Renal Blood Flow , Amer J Physiol 206:309-312 ( (Feb) ) 1964;.
Stamey, T.A., et al:  Functional Characteristics of Renovascular Hypertension , Medicine 40:347-394 ( (Dec) ) 1961;.

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Cotlove, E.:  C14 Inulin Method, Carboxyl-Labeled Inulin as a Tracer for Inulin , Fed Proc 14:32, 1955;.
Concannon, J.P., et al:  I125 Allyl Inulin for the Determination of Glomerular Filtration Rate , Amer J Roentgen 92:302-308 ( (Aug) ) 1964;.
Tauxe, W.M., et al:  Renal Clearances , Proc Mayo Clin 39: 761-766 ( (Oct) ) 1964;.
Sigman, E.M., et al:  The Renal Clearance of I131-Labeled Sodium Iothalamate in Man , Invest Urol 2:432-438 ( (March) ) 1965;.
Morris, A.M., et al:  The Renal Clearance of I131-Labeled Meglumine Diatrizoate (Renografin) , J Nucl Med 6:183-192 ( (March) ) 1965;.
Smith, H.W., et al:  The Renal Clearances of Substituted Hippuric Acid Derivatives and Other Aromatic Acids in Dog and Man , J Clin Invest 24:388-404 ( (Sept) ) 1945;.
Schlegel, J.U.; Smith, B.G.; and O'Dell, R.M.:  Estimation of Effective Renal Plasma Flow Using I131-Labeled Hippuran , J Appl Physiol 17:80-82 ( (Jan) ) 1962;.
Schwartz, F.D., and Madeloff, M.S.:  Simultaneous Renal Clearances of Radio-Hippuran and PAH in Man . Clin Res 9:208, 1961;.
Bergström, J.; Bucht, H.; and Josephson, B.:  Determination of the Renal Blood Flow in Man by Means of Radioactive Diodrast and Renal Vein Catheterization , Scand J Clin Lab Invest 11:71-81 ( (Jan) ) 1959;.
Smith, H.W.; Goldring, W.; and Chasis, H.:  The Measurement of the Tubular Excretory Mass, Effective Blood Flow, and Filtration Rate in the Normal Human Kidney , J Clin Invest 17:263-278 ( (Feb) ) 1938;.
Block, J.B., and Burrows, B.A.:  Influence of Serum Protein Binding on Renal Clearance of I131-Labeled Diodrast , J Lab Clin Med 56:463-472 ( (Sept) ) 1960;.
Josephson, B., et al:  The Competition Between P-Amino-Hippuric Acid (PAH) and Diodrast for Renal Excretion and Extraction in Man , J Clin Invest 32:1184-1191 ( (Nov) ) 1953;.
Chasis, H., et al:  The Use of Sodium P-Aminohippurate for the Functional Evaluation of the Human Kidney , J Clin Invest 24:583-588 ( (Sept) ) 1945;.
Schlungbaum, W., and Billion, H.:  Die Bestimmung der Effektiven Plasma-Nierendurchströmung mit Radioaktivem, mit I131 Markiertem Perabrodil-M , Sonderbände zur Strahlentherapie 36:145-150 ( (March) ) 1956;.
Parker, R.H., and Beierwaltes, W.H.:  I131 Diodrast for the Determination of Renal Clearance and Renal Tubular Mass , J Nucl Med 1:41-49 ( (Jan) ) 1960;.
Fozzard, H.A.:  Diodrast (I131) Whole Blood Clearance as an Index of Renal Blood Flow , Amer J Physiol 206:309-312 ( (Feb) ) 1964;.
Stamey, T.A., et al:  Functional Characteristics of Renovascular Hypertension , Medicine 40:347-394 ( (Dec) ) 1961;.
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