Effect of Transplantation of Canine Lung on Pulmonary Compliance and Surfactant FREE

John A. Waldhausen, MD; Samuel T. Giammona, MD; James W. Kilman, MD; Walter J. Daly, MD

[+] Author Affiliations

Read before the session on transplantation of the Fourth Multiple Discipline Research Forum during the 113th annual convention of the American Medical Association, San Francisco, June 24, 1964.

Reprint requests to 1100 W Michigan St, Indianapolis 7 (Dr. Waldhausen).

From the departments of surgery, pediatrics, and medicine, Indiana University School of Medicine, Indianapolis.

JAMA. 1965;191(12):1002-1005. doi:10.1001/jama.1965.03080120036009

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References

ABSTRACT

ABSTRACT | REFERENCES

Lung transplantation appears to be one potential J approach to the management of such pulmonary diseases as severe emphysema. Present methods, however, do not permit adequate control of the rejection of homografts. In addition, the functional capacity of the autotransplanted lung is not completely understood. Pulmonary hypertension and a decrease in oxygen consumption have been described following reimplantation of the lung in dogs.^1,2 Previous studies report rare survival of dogs with an autotransplanted lung following a contralateral pneumonectomy. Others have emphasized the serious loss of respiratory reflexes following total lung denervation.³ In contrast, Hardy and his associates⁴ state that although an autotransplanted lung may show impaired function early, there occurs "functional recovery of the reimplanted lung and probable regeneration of vagal nerve fibers to this organ."

It is now well substantiated that surface forces are important in determining the mechanical behavior of the lung and that the

REFERENCES

ABSTRACT | REFERENCES

Nigro, S.L., et al: Physiologic Alterations of Cardiopulmonary Function in Dogs Living One and One-Half Years on Only Reimplanted Right Lung , J Thorac Cardio Surg 46:598-605, 1963;.

Reemtsma, K., et al: Studies of Pulmonary Function in Transplantation of Canine Lung , J Thorac Cardiov Surg 46:589-597, 1963;.

Ballinger, W.F. II, et al: Effects of Cardiopulmonary Denervation , Surgery 55:574, 1964;.

Hardy, J.D.; Eraslan, S.S.; and Dalton, M.L.: Autotransplantation and Homotransplantation of Lung: Further Studies , J Thorac Cardiov Surg 46:606-615, 1963;.

Giammona, S.T.; Mandelbaum, I.; and Bondurant, S.: Relationship of Pulmonary Stability and Surfactant , Fed Proc 23:156, 1964;.

Gruenwald, P.: Numerical Index of Stability of Lung Expansion , J Appl Physiol 18:665-667, 1963;.

Clements, J.A.: Surface Phenomena in Relation to Pulmonary Function , Physiologist 5:11-28, 1962;.

Bondurant, S., and Miller, D.A.: Method for Producing Surface Active Extracts of Mammalian Lungs , J Appl Physiol 17:167-168, 1962;.

Pattle, R.E.: Properties, Function and Origin of the Alveoli Lining Layer , Proc Roy Soc [Biol] 148:217-240, 1958;.

Klaus, M.H., et al: Alveolar Epithelial Cell Mitochondria as Source of Active Lung Lining , Science 137:750, 1962;.

Avery, M.E., and Chernick, V.: Alterations of Alveolar Lining Layer in Living Rabbits , J Pediat 63:762, 1963;.

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