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CLINICAL NOTES |

Temporary Impairment of Vitamin B12 Absorption: Title and subTitle BreakAnother Side Effect of Therapeutic Gastric Freezing

Hendrick B. Barner, MD; Theodore I. Jones, MD; Thomas B. Garlick, MD
[+] Author Affiliations

Reprint requests to 260 Crittenden Blvd, Rochester, NY 14620 (Dr. Barner).


Rochester, NY

From the Department of Surgery, Highland Hospital.


JAMA. 1964;190(8):779-781. doi:10.1001/jama.1964.03070210085026
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WIDESPREAD use of gastric freezing rapidly followed its introduction for the treatment of peptic ulcer. Despite this current vogue therapeutic results have been variable and temporary, and several hazards are known to be associated with the technique, We have demonstrated another untoward side effect which was previously thought not to occur.1

Method  Twelve male and four female patients, 24 to 67 years of age, with nonobstructing peptic ulceration of the duodenum documented by an upper gastro-intestinal study received a single, 60-minute period of gastric freezing employing a gastric hypothermia machine, as described by Peter and co-workers.2 Inflow temperatures of —15 to —19 C (5 to —2.2 F) and outflow temperatures of —11 to —14 C (12.2 to 6.8 F) were maintained with a constant flow rate of 500 cc per minute. The volume of the standard, latex rubber balloon was the maximal consistent with patient comfort and ranged

REFERENCES

Bernstein, E.F., et al:  Interim Report on Results of Gastric Freezing for Peptic Ulcer , JAMA 187:436-411 ( (Feb 8) ) 1964;.
Peter, E.T., et al:  Technique of Gastric Freezing in Treatment of Duodenal Ulcer , JAMA 181:760-764 ( (Sept 1) ) 1962;.
Bernstein, E.F., and Wangensteen, O.H.: Personal communication to the authors.
Schilling, R.F.; Clatanoff, D.V.; and Korst, D.R.:  Intrinsic Factor Studies: III. Further Observations Utilizing Urinary Radioactivity Test in Subjects With Achlorhydria, Pernicious Anemia, or Total Gastrectomy , J Lab Clin Med 45:926-934, 1955;.
Lippman, H.N.; Morgenstern, L.; and Panish, J.F.:  Etiology and Prevention of Gross Mucosal Lesions Seen After Gastric Freezing , JAMA 187:265-269 ( (Jan 25) ) 1964;.
Needed:  Double Blind Study of Gastric Freezing Technique, Medical News , JAMA 185, (July 20) , 1963;, adv pp 32-33.
Muyshondt, E., and Schwartz, S.I.:  Vitamin B12 Absorption Following Vaginectomy and Gastric Surgery , Ann Surg , to be published.
Wangensteen, O.H., et al:  Can Physiologic Gastrectomy Be Achieved by Gastric Freezing , Ann Surg 156:579-591, 1962;.
Toporek, M.:  Relation of Binding Power to Intrinsic Factor Activity: Effect of Pseudo-Vitamin B-12 on Absorption of Vitamin B-12 , Amer J Clin Nutr 8:297-300, 1960;.

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Bernstein, E.F., et al:  Interim Report on Results of Gastric Freezing for Peptic Ulcer , JAMA 187:436-411 ( (Feb 8) ) 1964;.
Peter, E.T., et al:  Technique of Gastric Freezing in Treatment of Duodenal Ulcer , JAMA 181:760-764 ( (Sept 1) ) 1962;.
Bernstein, E.F., and Wangensteen, O.H.: Personal communication to the authors.
Schilling, R.F.; Clatanoff, D.V.; and Korst, D.R.:  Intrinsic Factor Studies: III. Further Observations Utilizing Urinary Radioactivity Test in Subjects With Achlorhydria, Pernicious Anemia, or Total Gastrectomy , J Lab Clin Med 45:926-934, 1955;.
Lippman, H.N.; Morgenstern, L.; and Panish, J.F.:  Etiology and Prevention of Gross Mucosal Lesions Seen After Gastric Freezing , JAMA 187:265-269 ( (Jan 25) ) 1964;.
Needed:  Double Blind Study of Gastric Freezing Technique, Medical News , JAMA 185, (July 20) , 1963;, adv pp 32-33.
Muyshondt, E., and Schwartz, S.I.:  Vitamin B12 Absorption Following Vaginectomy and Gastric Surgery , Ann Surg , to be published.
Wangensteen, O.H., et al:  Can Physiologic Gastrectomy Be Achieved by Gastric Freezing , Ann Surg 156:579-591, 1962;.
Toporek, M.:  Relation of Binding Power to Intrinsic Factor Activity: Effect of Pseudo-Vitamin B-12 on Absorption of Vitamin B-12 , Amer J Clin Nutr 8:297-300, 1960;.
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