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Original Contributions |

Dengue Fever: A Thrombocytopenic Disease?

Ethel R. Nelson, MD; Howard R. Bierman, MD
[+] Author Affiliations

Reprint requests to 321 S Robertson Blvd, Beverly Hills, Calif (Dr. Bierman).


Bangkok, Thailand; Beverly Hills, Calif

From Bangkok Sanitarium and Hospital (Dr. Nelson) and the Institute for Cancer and Blood Research (Dr. Bierman).


JAMA. 1964;190(2):99-103. doi:10.1001/jama.1964.03070150009002
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In a study of dengue fever in Thailand, bone-marrow examinations showed hypocellularity early in the disease, followed by hypercullarity during recovery and normocellularity in convalescence. Thrombocytopenia due to megakaryocytic suppression was a characteristic. In 18 patients with early dengue, thrombocytopenia lasted one to four days; platelet counts in 8 were less than 50,000/cu cm. Petechiae or other bleeding manifestations were noted in 15 patients. Intensive hematologic studies of dengue infections in other geographic areas are suggested, to determine if thrombocytopenia is a universal characteristic of this and related virus diseases.

REFERENCES

Pepper, O.H.P.:  Note on David Bylon and Dengue , Ann Med History 3:363-368 ( (Sept) ) 1941;.
Scott, L.C.:  Dengue Fever in Louisiana , JAMA 80: 387-393 ( (Feb 10) ) 1923;.
Rice, L.:  Dengue Fever , Amer J Trop Med 3:73-90 ( (March) ) 1923;.
Georgopoulous, M.:  Die Prüfung des Zustandes der Peripheren Gafosse als Methode zur Frühzeitigen and Sicheren Diagnose des Denguefiebers , Munchen Med Wschr 75:1793-1794, 1928;.
Walker, A.S.; Meyers, E.; and Woodhill, A.R.:  Dengue Fever , Med J Aust 29 (pt (2) ):223-228 (Sept 12) 1942;.
Stewart, F.H.:  Dengue: Analysis of Clinical Syndrome in South Pacific Advance Base , US Navy Med Bull 42:1233-1240 ( (June) ) 1944;.
Kisner, P., and Lisansky, E.T.:  Analysis of Epidemic of Dengue Fever , Ann Intern Med 20:41-51 ( (Jan) ) 1944;.
Block, W.M.:  Dengue: Report of Epidemic , J Iowa Med Soc 35:461-466 ( (Dec) ) 1945;.
Rowan, L.C.:  Epidemic of Dengue-Like Fever, Townsville, 1954: Clinical Features With Review of Literature , Med J Aust 43:651-655, 1956;.
Lunsden, W.H.R.:  Etiology of "Dengue," E Afr Med J 35:519-526, 1958;.
Miller, J.E.:  Dengue: Study of 100 Cases , US Navy Med Bull 27:77-86 ( (Jan) ) 1929;.
Simmons, J.S.:  Dengue Fever , Amer J Trop Med 11:77-102 ( (March) ) 1931;.
Sabin, A.B.:  Research on Dengue During World War II , Amer J Trop Med 1:30-50, 1952;.
Nelson, E.R.; Bierman, H.R.; and Chulajata, R.:  Hematologic Findings in 1960 Hemorrhagic Fever Epidemic (Dengue) in Thailand , Amer J Trop Med 13:642-649 ( (July) ) 1964;.
Bierman, H.R., and Nelson, E.R.:  Relationship Between Epidemic Hemorrhagic Fever and Dengue in Thailand , abstracted, Clin Res 11:1, 109 ( (Jan) ) 1963;.
Hammon, W.M.; Rudnick, A.; and Sather, G.E.:  Viruses Associated With Epidemic Hemorrhagic Fever of Philippines and Thailand , Science 131:1102-1103, 1960;.
Nelson, E.R.:  Hemorrhagic Fever in Children in Thailand: Report of 69 Cases , J Pediat 56:101-108, 1960;.
Dassaneyawaja, A., and Pongsupat, S.:  Observations on Thai Hemorrhagic Fever , J Trop Med 64:310-314, 1961;.
Chew, A., et al:  Hemorrhagic Fever in Singapore , Lancet 1:307-310, 1961;.

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Pepper, O.H.P.:  Note on David Bylon and Dengue , Ann Med History 3:363-368 ( (Sept) ) 1941;.
Scott, L.C.:  Dengue Fever in Louisiana , JAMA 80: 387-393 ( (Feb 10) ) 1923;.
Rice, L.:  Dengue Fever , Amer J Trop Med 3:73-90 ( (March) ) 1923;.
Georgopoulous, M.:  Die Prüfung des Zustandes der Peripheren Gafosse als Methode zur Frühzeitigen and Sicheren Diagnose des Denguefiebers , Munchen Med Wschr 75:1793-1794, 1928;.
Walker, A.S.; Meyers, E.; and Woodhill, A.R.:  Dengue Fever , Med J Aust 29 (pt (2) ):223-228 (Sept 12) 1942;.
Stewart, F.H.:  Dengue: Analysis of Clinical Syndrome in South Pacific Advance Base , US Navy Med Bull 42:1233-1240 ( (June) ) 1944;.
Kisner, P., and Lisansky, E.T.:  Analysis of Epidemic of Dengue Fever , Ann Intern Med 20:41-51 ( (Jan) ) 1944;.
Block, W.M.:  Dengue: Report of Epidemic , J Iowa Med Soc 35:461-466 ( (Dec) ) 1945;.
Rowan, L.C.:  Epidemic of Dengue-Like Fever, Townsville, 1954: Clinical Features With Review of Literature , Med J Aust 43:651-655, 1956;.
Lunsden, W.H.R.:  Etiology of "Dengue," E Afr Med J 35:519-526, 1958;.
Miller, J.E.:  Dengue: Study of 100 Cases , US Navy Med Bull 27:77-86 ( (Jan) ) 1929;.
Simmons, J.S.:  Dengue Fever , Amer J Trop Med 11:77-102 ( (March) ) 1931;.
Sabin, A.B.:  Research on Dengue During World War II , Amer J Trop Med 1:30-50, 1952;.
Nelson, E.R.; Bierman, H.R.; and Chulajata, R.:  Hematologic Findings in 1960 Hemorrhagic Fever Epidemic (Dengue) in Thailand , Amer J Trop Med 13:642-649 ( (July) ) 1964;.
Bierman, H.R., and Nelson, E.R.:  Relationship Between Epidemic Hemorrhagic Fever and Dengue in Thailand , abstracted, Clin Res 11:1, 109 ( (Jan) ) 1963;.
Hammon, W.M.; Rudnick, A.; and Sather, G.E.:  Viruses Associated With Epidemic Hemorrhagic Fever of Philippines and Thailand , Science 131:1102-1103, 1960;.
Nelson, E.R.:  Hemorrhagic Fever in Children in Thailand: Report of 69 Cases , J Pediat 56:101-108, 1960;.
Dassaneyawaja, A., and Pongsupat, S.:  Observations on Thai Hemorrhagic Fever , J Trop Med 64:310-314, 1961;.
Chew, A., et al:  Hemorrhagic Fever in Singapore , Lancet 1:307-310, 1961;.
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