Baboon Renal Grafts

Claude R. Hitchcock, MD, PhD; Joseph C. Kiser, MD; Robert L. Telander, MD; Edward L. Seljeskog, MD

[+] Author Affiliations

Minneapolis

From the laboratories of the Minneapolis Medical Research Foundation, Inc, at Hennepin County General Hospital. Portions of these studies were conducted at the field laboratories of the Southwest Foundation for Research at Darajani, Kenya, East Africa; and also at the Southwest Laboratories for Research, San Antonio, Tex.

JAMA. 1964;189(12):934-937. doi:10.1001/jama.1964.03070120056013

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References

ABSTRACT

ABSTRACT | REFERENCES

IN OCTOBER, 1960, experiments were begun testing the usefulness of the large Kenya baboon for renal grafting. Previously reported studies^1,2 had indicated a physiological closeness of the Kenya baboon (Papio doguera) to man which was unusual in the animal world. Atherosclerosis had been shown to occur naturally in about 5% to 10% of older baboons,³ and electrophoretic tracings of baboon sera made in our own laboratories could be superimposed on similar tracings of human sera.

The initial studies with baboon kidney autografts and homografts were promising, and on Feb 16, 1963, the right kidney of a male baboon was implanted into the left thigh of an Indian woman suffering from terminal uremia secondary to severe pyelonephritis. The kidney functioned well for 41/2 days and served to dialyze the patient to near normal blood chemistry levels.

Report of a Case A 65-year-old Indian woman (hospital No. A-18785) had

REFERENCES

ABSTRACT | REFERENCES

Lindsay, S., and Chaikoft, I.L.: Arteriosclerosis in Baboon , Arch Path (Chicago) 63:460, 1957;.

Gillman, J., and Gilbert, C.: Atherosis in Baboon (Papio ursinus), Its Pathogenesis and Etilogy , Exper Med Surg 15:181, 1957;.

McGill, H.C., Jr., et al: Arterial Lesions in the Kenya Baboon , Circ Res 8:670-679 ( (May) ) 1960;.

Simso, L.A.; Telander, R.L.; and Hitchcock, C.R.: Hypertension Following Renal Autografting in Kenya Baboon , Surg Forum Surgeons 14:170, 1963;.

Hitchcock, C.R., et al: Effect of Low Molecular Weight Dextran on Organ Persusion and Sludging , J Surg , to be published.

Ullmann, E.: Experimentelle Nierentransplantation. Verläufige Mitteilung , Wien Klin Wschr 15:281, 1902;.

Unger, E.: Über Nierentransplantation , Zbl Chir , 31:26, 1910;.

Carrel, A.: Transplantation of Organs , New York J Med 99:839, 1914;.

Wiener, A.S., and Moor-Jankowski, J.: Blood Groups in Anthropoid Apes and Baboons , Science 142:67-69 ( (Oct 4) ) 1963;.

Moor-Jankowski, J., and Brown, K.S.: Serum Antigens in Mammals: Crossreacting Iso-Immune and Hetero-Immune Systems , Exp Med Surg 21:148-152 ( (June) -Sept) 1963;.

Reemtsma, K., et al: Reversal of Early Graft Rejection After Renal Heterotransplantation in Man , JAMA 187:691-696, ( (March 7) ) 1964;.

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