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Original Contributions |

Serum Cholesterol Values in Patients Treated Surgically for Atherosclerosis

H. Edward Garrett, MD; Evan C. Horning, PhD; Billy G. Creech, PhD; Michael De Bakey, MD
[+] Author Affiliations

Houston

From the Cora and Webb Mading Department of Surgery, the Lipid Research Center of the Department of Biochemistry, and the Goldston Cardiovascular Research Unit, Baylor University College of Medicine, and the laboratory service of the Methodist Hospital.


JAMA. 1964;189(9):655-659. doi:10.1001/jama.1964.03070090005001
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An analysis of cholesterol values by usual hospital laboratory methods in 1,700 patients with atherosclerotic disease revealed no definite correlation between serum cholesterol levels and the nature and extent of atherosclerotic disease. Eight out of ten patients had cholesterol values below 300 mg/100 ml, the upper limits of normal for the procedure employed. Associated diseases such as diabetes mellitus and arteriosclerotic heart disease, age, and anatomical location and extent of atherosclerotic disease did not significantly alter the distribution of cholesterol values. Although an elevated cholesterol level may be a factor in abnormal lipid metabolism and associated atherosclerotic disease, the majority of patients in this group had serum cholesterol values within the accepted normal range for Americans.

REFERENCES

Keys, A., and Grande, F.:  Role of Dietary Fat in Human Nutrition: III. Diet and Epidemiology of Coronary Heart Disease , Amer J Public Health 47:1520-1530 ( (Dec) ) 1957;.
Keys, A.:  Calories and Cholesterol , Geriatrics 12:301-310 ( (May) ) 1957;.
Wright, L.D.:  Antihypercholesterolemic Agents , New York J Med 62:859-861 ( (March 15) ) 1962;.
Bernstein, A., and Simon, F.:  Cholesterol Reduction in Patients With Arteriosclerosis , Angiology 13:79-80 ( (Feb) ) 1962;.
Talbott, G.D.:  Limitations of Serum Cholesterol Level as Diagnostic Index of Cardiovascular Status , J Amer Geriat Soc 9:825-832 ( (Oct) ) 1961;.
Heyman, A.; Nefzger, M.D.; and Estes, E.H., Jr.:  Serum Cholesterol Level in Cerebral Infarction , Arch Neurol (Chicago) 5:264-268, 1961;.
Pearson, S.; Stern, S.; and McGavack, T.H.:  Rapid, Accurate Method for Determination of Total Cholesterol in Serum , Anal Chem 25:813-814, 1953;.
Abell, L.L., et al:  Simplified Method for Estimation of Total Cholesterol in Serum and Demonstration of Its Specificity , J Biol Chem 195:357-366 ( (March) ) 1952;.
Nikkilä, E., and Pelkonen, R.:  Serum Tocopherol, Cholesterol, and Triglyceride in Coronary Heart Disease , Circulation 27:919-928 ( (May) ) 1963;.
Creech, B.G., and Sewell, B.W.:  Rapid Micro Procedure for Determination of Free and Esterified Cholesterol in Blood Serum Using Silicic Acid Separation , Anal Biochem 3:119-123 ( (Feb) ) 1962;.
Hanel, H.K., and Dam, H., cited by Horning, M.G.: Lipid Pharmacology , R. Paoletti, ed., New York: Academic Press, 1964;, p 20.
Page, I.H., and Moinuddin, M.:  Effect of Venous Occlusion on Serum Cholesterol and Total Protein Concentration—A. Warning , Circulation 25:651-652 ( (April) ) 1962;.
Rivin, A.U., et al:  Serum Cholesterol Measurement-Hazards in Clinical Interpretation , JAMA 166:2108-2111 ( (April 26) ) 1958;.
Bronte-Stewart, B., and Krut, L.H.:  Interdependence of Prospective and Retrospective Studies in Research on Ischaemic Heart Disease , J Atheroscler Res 2:317-331 ( (Sept) -Oct) 1962;.
Keys, A., et al:  Coronary Heart Disease Among Minnesota Business and Professional Men Followed Fifteen Years , Circulation 28:381-395 ( (Sept) ) 1963;.

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Keys, A., and Grande, F.:  Role of Dietary Fat in Human Nutrition: III. Diet and Epidemiology of Coronary Heart Disease , Amer J Public Health 47:1520-1530 ( (Dec) ) 1957;.
Keys, A.:  Calories and Cholesterol , Geriatrics 12:301-310 ( (May) ) 1957;.
Wright, L.D.:  Antihypercholesterolemic Agents , New York J Med 62:859-861 ( (March 15) ) 1962;.
Bernstein, A., and Simon, F.:  Cholesterol Reduction in Patients With Arteriosclerosis , Angiology 13:79-80 ( (Feb) ) 1962;.
Talbott, G.D.:  Limitations of Serum Cholesterol Level as Diagnostic Index of Cardiovascular Status , J Amer Geriat Soc 9:825-832 ( (Oct) ) 1961;.
Heyman, A.; Nefzger, M.D.; and Estes, E.H., Jr.:  Serum Cholesterol Level in Cerebral Infarction , Arch Neurol (Chicago) 5:264-268, 1961;.
Pearson, S.; Stern, S.; and McGavack, T.H.:  Rapid, Accurate Method for Determination of Total Cholesterol in Serum , Anal Chem 25:813-814, 1953;.
Abell, L.L., et al:  Simplified Method for Estimation of Total Cholesterol in Serum and Demonstration of Its Specificity , J Biol Chem 195:357-366 ( (March) ) 1952;.
Nikkilä, E., and Pelkonen, R.:  Serum Tocopherol, Cholesterol, and Triglyceride in Coronary Heart Disease , Circulation 27:919-928 ( (May) ) 1963;.
Creech, B.G., and Sewell, B.W.:  Rapid Micro Procedure for Determination of Free and Esterified Cholesterol in Blood Serum Using Silicic Acid Separation , Anal Biochem 3:119-123 ( (Feb) ) 1962;.
Hanel, H.K., and Dam, H., cited by Horning, M.G.: Lipid Pharmacology , R. Paoletti, ed., New York: Academic Press, 1964;, p 20.
Page, I.H., and Moinuddin, M.:  Effect of Venous Occlusion on Serum Cholesterol and Total Protein Concentration—A. Warning , Circulation 25:651-652 ( (April) ) 1962;.
Rivin, A.U., et al:  Serum Cholesterol Measurement-Hazards in Clinical Interpretation , JAMA 166:2108-2111 ( (April 26) ) 1958;.
Bronte-Stewart, B., and Krut, L.H.:  Interdependence of Prospective and Retrospective Studies in Research on Ischaemic Heart Disease , J Atheroscler Res 2:317-331 ( (Sept) -Oct) 1962;.
Keys, A., et al:  Coronary Heart Disease Among Minnesota Business and Professional Men Followed Fifteen Years , Circulation 28:381-395 ( (Sept) ) 1963;.
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